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Revisiting the biosynthesis of dehydrophos reveals a tRNA-dependent pathway.

Bougioukou DJ, Mukherjee S, van der Donk WA.

Proc Natl Acad Sci U S A. 2013 Jul 2;110(27):10952-7. doi: 10.1073/pnas.1303568110. Epub 2013 Jun 17.


tRNA-dependent peptide bond formation by the transferase PacB in biosynthesis of the pacidamycin group of pentapeptidyl nucleoside antibiotics.

Zhang W, Ntai I, Kelleher NL, Walsh CT.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12249-53. doi: 10.1073/pnas.1109539108. Epub 2011 Jul 11.


Molecular cloning and heterologous expression of the dehydrophos biosynthetic gene cluster.

Circello BT, Eliot AC, Lee JH, van der Donk WA, Metcalf WW.

Chem Biol. 2010 Apr 23;17(4):402-11. doi: 10.1016/j.chembiol.2010.03.007.


The antibiotic dehydrophos is converted to a toxic pyruvate analog by peptide bond cleavage in Salmonella enterica.

Circello BT, Miller CG, Lee JH, van der Donk WA, Metcalf WW.

Antimicrob Agents Chemother. 2011 Jul;55(7):3357-62. doi: 10.1128/AAC.01483-10. Epub 2011 May 2.


Characterization and structure of DhpI, a phosphonate O-methyltransferase involved in dehydrophos biosynthesis.

Lee JH, Bae B, Kuemin M, Circello BT, Metcalf WW, Nair SK, van der Donk WA.

Proc Natl Acad Sci U S A. 2010 Oct 12;107(41):17557-62. doi: 10.1073/pnas.1006848107. Epub 2010 Sep 27.


Evolutionary flux of potentially bldA-dependent Streptomyces genes containing the rare leucine codon TTA.

Chandra G, Chater KF.

Antonie Van Leeuwenhoek. 2008 Jun;94(1):111-26. doi: 10.1007/s10482-008-9231-5. Epub 2008 Mar 5.


Pleiotropic regulatory genes bldA, adpA and absB are implicated in production of phosphoglycolipid antibiotic moenomycin.

Makitrynskyy R, Ostash B, Tsypik O, Rebets Y, Doud E, Meredith T, Luzhetskyy A, Bechthold A, Walker S, Fedorenko V.

Open Biol. 2013 Oct 23;3(10):130121. doi: 10.1098/rsob.130121.


Biosynthesis of albomycin δ(2) provides a template for assembling siderophore and aminoacyl-tRNA synthetase inhibitor conjugates.

Zeng Y, Kulkarni A, Yang Z, Patil PB, Zhou W, Chi X, Van Lanen S, Chen S.

ACS Chem Biol. 2012 Sep 21;7(9):1565-75. Epub 2012 Jun 25.


Use of a phosphonate methyltransferase in the identification of the fosfazinomycin biosynthetic gene cluster.

Gao J, Ju KS, Yu X, Velásquez JE, Mukherjee S, Lee J, Zhao C, Evans BS, Doroghazi JR, Metcalf WW, van der Donk WA.

Angew Chem Int Ed Engl. 2014 Jan 27;53(5):1334-7. doi: 10.1002/anie.201308363. Epub 2013 Dec 27.


Biosynthesis of selenocysteine on its tRNA in eukaryotes.

Xu XM, Carlson BA, Mix H, Zhang Y, Saira K, Glass RS, Berry MJ, Gladyshev VN, Hatfield DL.

PLoS Biol. 2007 Jan;5(1):e4.


ATPase-promoting dead end inhibitors of the cAMP-dependent protein kinase.

Mendelow M, Prorok M, Salerno A, Lawrence DS.

J Biol Chem. 1993 Jun 15;268(17):12289-96.


A response-regulator-like activator of antibiotic synthesis from Streptomyces coelicolor A3(2) with an amino-terminal domain that lacks a phosphorylation pocket.

Guthrie EP, Flaxman CS, White J, Hodgson DA, Bibb MJ, Chater KF.

Microbiology. 1998 Mar;144 ( Pt 3):727-38. Erratum in: Microbiology 1998 Jul;144(Pt 7):2007.


Combined effect of the DeltaPhe or DeltaAla residue and the p-nitroanilide group on a didehydropeptides conformation.

Lisowski M, Latajka R, Picur B, Lis T, Bryndal I, Rospenk M, Makowski M, Kafarski P.

Biopolymers. 2008 Mar;89(3):220-34.


tRNA-independent pretransfer editing by class I leucyl-tRNA synthetase.

Zhu B, Yao P, Tan M, Eriani G, Wang ED.

J Biol Chem. 2009 Feb 6;284(6):3418-24. doi: 10.1074/jbc.M806717200. Epub 2008 Dec 9.


Allosteric interaction of nucleotides and tRNA(ala) with E. coli alanyl-tRNA synthetase.

Dignam JD, Guo J, Griffith WP, Garbett NC, Holloway A, Mueser T.

Biochemistry. 2011 Nov 15;50(45):9886-900. doi: 10.1021/bi2012004. Epub 2011 Oct 19.


Sequences of tRNA-encoding genes and associated open reading frames of Streptomyces lividans.

Sedlmeier R, Linti G, Gregor K, Schmieger H.

Gene. 1993 Sep 30;132(1):125-30.


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