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Items: 1 to 20 of 110

1.

Adaptation-based resistance to siderophore-conjugated antibacterial agents by Pseudomonas aeruginosa.

Tomaras AP, Crandon JL, McPherson CJ, Banevicius MA, Finegan SM, Irvine RL, Brown MF, O'Donnell JP, Nicolau DP.

Antimicrob Agents Chemother. 2013 Sep;57(9):4197-207. doi: 10.1128/AAC.00629-13. Epub 2013 Jun 17.

2.

Potentiation of antibacterial activity of the MB-1 siderophore-monobactam conjugate using an efflux pump inhibitor.

Tomaras AP, Crandon JL, McPherson CJ, Nicolau DP.

Antimicrob Agents Chemother. 2015 Apr;59(4):2439-42. doi: 10.1128/AAC.04172-14. Epub 2015 Jan 20.

3.

Pharmacodynamic Profiling of a Siderophore-Conjugated Monocarbam in Pseudomonas aeruginosa: Assessing the Risk for Resistance and Attenuated Efficacy.

Kim A, Kutschke A, Ehmann DE, Patey SA, Crandon JL, Gorseth E, Miller AA, McLaughlin RE, Blinn CM, Chen A, Nayar AS, Dangel B, Tsai AS, Rooney MT, Murphy-Benenato KE, Eakin AE, Nicolau DP.

Antimicrob Agents Chemother. 2015 Dec;59(12):7743-52. doi: 10.1128/AAC.00831-15. Epub 2015 Oct 5.

4.

Pyridone-conjugated monobactam antibiotics with gram-negative activity.

Brown MF, Mitton-Fry MJ, Arcari JT, Barham R, Casavant J, Gerstenberger BS, Han S, Hardink JR, Harris TM, Hoang T, Huband MD, Lall MS, Lemmon MM, Li C, Lin J, McCurdy SP, McElroy E, McPherson C, Marr ES, Mueller JP, Mullins L, Nikitenko AA, Noe MC, Penzien J, Plummer MS, Schuff BP, Shanmugasundaram V, Starr JT, Sun J, Tomaras A, Young JA, Zaniewski RP.

J Med Chem. 2013 Jul 11;56(13):5541-52. doi: 10.1021/jm400560z. Epub 2013 Jun 27.

PMID:
23755848
5.

Discovery of efficacious Pseudomonas aeruginosa-targeted siderophore-conjugated monocarbams by application of a semi-mechanistic pharmacokinetic/pharmacodynamic model.

Murphy-Benenato KE, Bhagunde PR, Chen A, Davis HE, Durand-Réville TF, Ehmann DE, Galullo V, Harris JJ, Hatoum-Mokdad H, Jahić H, Kim A, Manjunatha MR, Manyak EL, Mueller J, Patey S, Quiroga O, Rooney M, Sha L, Shapiro AB, Sylvester M, Tan B, Tsai AS, Uria-Nickelsen M, Wu Y, Zambrowski M, Zhao SX.

J Med Chem. 2015 Mar 12;58(5):2195-205. doi: 10.1021/jm501506f. Epub 2015 Mar 3.

PMID:
25658376
6.

Involvement of Fe uptake systems and AmpC β-lactamase in susceptibility to the siderophore monosulfactam BAL30072 in Pseudomonas aeruginosa.

van Delden C, Page MG, Köhler T.

Antimicrob Agents Chemother. 2013 May;57(5):2095-102. doi: 10.1128/AAC.02474-12. Epub 2013 Feb 19.

7.

Siderophore-dependent iron uptake systems as gates for antibiotic Trojan horse strategies against Pseudomonas aeruginosa.

Mislin GL, Schalk IJ.

Metallomics. 2014 Mar;6(3):408-20. doi: 10.1039/c3mt00359k. Epub 2014 Jan 31. Review.

PMID:
24481292
8.

Clinically relevant Gram-negative resistance mechanisms have no effect on the efficacy of MC-1, a novel siderophore-conjugated monocarbam.

McPherson CJ, Aschenbrenner LM, Lacey BM, Fahnoe KC, Lemmon MM, Finegan SM, Tadakamalla B, O'Donnell JP, Mueller JP, Tomaras AP.

Antimicrob Agents Chemother. 2012 Dec;56(12):6334-42. doi: 10.1128/AAC.01345-12. Epub 2012 Oct 1.

9.

In vitro properties of BAL30072, a novel siderophore sulfactam with activity against multiresistant gram-negative bacilli.

Page MG, Dantier C, Desarbre E.

Antimicrob Agents Chemother. 2010 Jun;54(6):2291-302. doi: 10.1128/AAC.01525-09. Epub 2010 Mar 22.

10.

In vivo pharmacodynamic profiling of doripenem against Pseudomonas aeruginosa by simulating human exposures.

Kim A, Banevicius MA, Nicolau DP.

Antimicrob Agents Chemother. 2008 Jul;52(7):2497-502. doi: 10.1128/AAC.01252-07. Epub 2008 May 5.

12.

Discovery of Novel Pyridone-Conjugated Monosulfactams as Potent and Broad-Spectrum Antibiotics for Multidrug-Resistant Gram-Negative Infections.

Tan L, Tao Y, Wang T, Zou F, Zhang S, Kou Q, Niu A, Chen Q, Chu W, Chen X, Wang H, Yang Y.

J Med Chem. 2017 Apr 13;60(7):2669-2684. doi: 10.1021/acs.jmedchem.6b01261. Epub 2017 Mar 23.

PMID:
28287720
13.

Manuka honey inhibits siderophore production in Pseudomonas aeruginosa.

Kronda JM, Cooper RA, Maddocks SE.

J Appl Microbiol. 2013 Jul;115(1):86-90. doi: 10.1111/jam.12222. Epub 2013 May 3.

14.

Activity of the siderophore monobactam BAL30072 against multiresistant non-fermenters.

Mushtaq S, Warner M, Livermore D.

J Antimicrob Chemother. 2010 Feb;65(2):266-70. doi: 10.1093/jac/dkp425. Epub 2009 Dec 8.

PMID:
19996139
15.

In vitro activity of the siderophore monosulfactam BAL30072 against contemporary Gram-negative pathogens from New York City, including multidrug-resistant isolates.

Landman D, Singh M, El-Imad B, Miller E, Win T, Quale J.

Int J Antimicrob Agents. 2014 Jun;43(6):527-32. doi: 10.1016/j.ijantimicag.2014.02.017. Epub 2014 Apr 13.

PMID:
24796217
16.

Antibacterial Properties of Tebipenem Pivoxil Tablet, a New Oral Carbapenem Preparation against a Variety of Pathogenic Bacteria in Vitro and in Vivo.

Yao Q, Wang J, Cui T, Yang Z, Su M, Zhao P, Yan H, Zhan Y, Yang H.

Molecules. 2016 Jan 6;21(1):62. doi: 10.3390/molecules21010062.

17.

Antimicrobial effects of novel siderophores linked to beta-lactam antibiotics.

Kline T, Fromhold M, McKennon TE, Cai S, Treiberg J, Ihle N, Sherman D, Schwan W, Hickey MJ, Warrener P, Witte PR, Brody LL, Goltry L, Barker LM, Anderson SU, Tanaka SK, Shawar RM, Nguyen LY, Langhorne M, Bigelow A, Embuscado L, Naeemi E.

Bioorg Med Chem. 2000 Jan;8(1):73-93.

PMID:
10968267
18.

Siderophore-antibiotic conjugates used as trojan horses against Pseudomonas aeruginosa.

Budzikiewicz H.

Curr Top Med Chem. 2001 May;1(1):73-82. Review.

PMID:
11895295
19.

In vitro and in vivo potency of polymyxin B against IMP-type metallo-beta-lactamase-producing Pseudomonas aeruginosa.

Miyajima Y, Hiramatsu K, Mizukami E, Morinaga R, Ishii H, Shirai R, Kishi K, Tokimatsu I, Saikawa T, Kadota J.

Int J Antimicrob Agents. 2008 Nov;32(5):437-40. doi: 10.1016/j.ijantimicag.2008.05.006. Epub 2008 Aug 19.

PMID:
18715759
20.

Comparative in vitro and in vivo efficacies of human simulated doses of ceftazidime and ceftazidime-avibactam against Pseudomonas aeruginosa.

Crandon JL, Schuck VJ, Banevicius MA, Beaudoin ME, Nichols WW, Tanudra MA, Nicolau DP.

Antimicrob Agents Chemother. 2012 Dec;56(12):6137-46. doi: 10.1128/AAC.00851-12. Epub 2012 Sep 17.

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