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Synergistic effects of curcumin with emodin against the proliferation and invasion of breast cancer cells through upregulation of miR-34a.

Guo J, Li W, Shi H, Xie X, Li L, Tang H, Wu M, Kong Y, Yang L, Gao J, Liu P, Wei W, Xie X.

Mol Cell Biochem. 2013 Oct;382(1-2):103-11. doi: 10.1007/s11010-013-1723-6. Epub 2013 Jun 15.


MiR-34a inhibits proliferation and migration of breast cancer through down-regulation of Bcl-2 and SIRT1.

Li L, Yuan L, Luo J, Gao J, Guo J, Xie X.

Clin Exp Med. 2013 May;13(2):109-17. doi: 10.1007/s10238-012-0186-5. Epub 2012 May 24.


Migration-prone glioma cells show curcumin resistance associated with enhanced expression of miR-21 and invasion/anti-apoptosis-related proteins.

Yeh WL, Lin HY, Huang CY, Huang BR, Lin C, Lu DY, Wei KC.

Oncotarget. 2015 Nov 10;6(35):37770-81. doi: 10.18632/oncotarget.6092.


Curcumin and emodin down-regulate TGF-β signaling pathway in human cervical cancer cells.

Thacker PC, Karunagaran D.

PLoS One. 2015 Mar 18;10(3):e0120045. doi: 10.1371/journal.pone.0120045. eCollection 2015.


Emodin-induced apoptosis in human breast cancer BCap-37 cells through the mitochondrial signaling pathway.

Huang Z, Chen G, Shi P.

Arch Pharm Res. 2008 Jun;31(6):742-8. doi: 10.1007/s12272-001-1221-6. Epub 2008 Jun 19.


Curcumin and synthetic analogs induce reactive oxygen species and decreases specificity protein (Sp) transcription factors by targeting microRNAs.

Gandhy SU, Kim K, Larsen L, Rosengren RJ, Safe S.

BMC Cancer. 2012 Nov 30;12:564. doi: 10.1186/1471-2407-12-564.


Hyaluronic acid-chitosan nanoparticles for co-delivery of MiR-34a and doxorubicin in therapy against triple negative breast cancer.

Deng X, Cao M, Zhang J, Hu K, Yin Z, Zhou Z, Xiao X, Yang Y, Sheng W, Wu Y, Zeng Y.

Biomaterials. 2014 May;35(14):4333-44. doi: 10.1016/j.biomaterials.2014.02.006. Epub 2014 Feb 22.


Curcumin inhibits cell growth and invasion through up-regulation of miR-7 in pancreatic cancer cells.

Ma J, Fang B, Zeng F, Pang H, Zhang J, Shi Y, Wu X, Cheng L, Ma C, Xia J, Wang Z.

Toxicol Lett. 2014 Nov 18;231(1):82-91. doi: 10.1016/j.toxlet.2014.09.014. Epub 2014 Sep 23.


Targeting epigenetic regulation of miR-34a for treatment of pancreatic cancer by inhibition of pancreatic cancer stem cells.

Nalls D, Tang SN, Rodova M, Srivastava RK, Shankar S.

PLoS One. 2011;6(8):e24099. doi: 10.1371/journal.pone.0024099. Epub 2011 Aug 31.


Emodin has a cytotoxic activity against human multiple myeloma as a Janus-activated kinase 2 inhibitor.

Muto A, Hori M, Sasaki Y, Saitoh A, Yasuda I, Maekawa T, Uchida T, Asakura K, Nakazato T, Kaneda T, Kizaki M, Ikeda Y, Yoshida T.

Mol Cancer Ther. 2007 Mar;6(3):987-94.


Curcumin reduces the expression of Bcl-2 by upregulating miR-15a and miR-16 in MCF-7 cells.

Yang J, Cao Y, Sun J, Zhang Y.

Med Oncol. 2010 Dec;27(4):1114-8. doi: 10.1007/s12032-009-9344-3. Epub 2009 Nov 12.


A synergistic antiproliferation effect of curcumin and docosahexaenoic acid in SK-BR-3 breast cancer cells: unique signaling not explained by the effects of either compound alone.

Altenburg JD, Bieberich AA, Terry C, Harvey KA, Vanhorn JF, Xu Z, Jo Davisson V, Siddiqui RA.

BMC Cancer. 2011 Apr 21;11:149. doi: 10.1186/1471-2407-11-149.


Dysregulation of BMI1 and microRNA-16 collaborate to enhance an anti-apoptotic potential in the side population of refractory mantle cell lymphoma.

Teshima K, Nara M, Watanabe A, Ito M, Ikeda S, Hatano Y, Oshima K, Seto M, Sawada K, Tagawa H.

Oncogene. 2014 Apr 24;33(17):2191-203. doi: 10.1038/onc.2013.177. Epub 2013 May 20.


Dihydroartemisinin and Curcumin Synergistically Induce Apoptosis in SKOV3 Cells Via Upregulation of MiR-124 Targeting Midkine.

Zhao J, Pan Y, Li X, Zhang X, Xue Y, Wang T, Zhao S, Hou Y.

Cell Physiol Biochem. 2017;43(2):589-601. doi: 10.1159/000480531. Epub 2017 Sep 21.


Curcumin reduces expression of Bcl-2, leading to apoptosis in daunorubicin-insensitive CD34+ acute myeloid leukemia cell lines and primary sorted CD34+ acute myeloid leukemia cells.

Rao J, Xu DR, Zheng FM, Long ZJ, Huang SS, Wu X, Zhou WH, Huang RW, Liu Q.

J Transl Med. 2011 May 19;9:71. doi: 10.1186/1479-5876-9-71.


Ketamine used as an acesodyne in human breast cancer therapy causes an undesirable side effect, upregulating anti-apoptosis protein Bcl-2 expression.

He H, Chen J, Xie WP, Cao S, Hu HY, Yang LQ, Gong B.

Genet Mol Res. 2013 Jun 13;12(2):1907-15. doi: 10.4238/2013.January.4.7.


Emodin induces cytotoxic effect in human breast carcinoma MCF-7 cell through modulating the expression of apoptosis-related genes.

Li WY, Chan RY, Yu PH, Chan SW.

Pharm Biol. 2013 Sep;51(9):1175-81. doi: 10.3109/13880209.2013.782322. Epub 2013 Jun 13.


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