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Items: 1 to 20 of 441

1.

Immunodetection of disease-associated conformers of mutant cu/zn superoxide dismutase 1 selectively expressed in degenerating neurons in amyotrophic lateral sclerosis.

Sábado J, Casanovas A, Hernández S, Piedrafita L, Hereu M, Esquerda JE.

J Neuropathol Exp Neurol. 2013 Jul;72(7):646-61. doi: 10.1097/NEN.0b013e318297fd10.

PMID:
23771221
2.

Adverse effects of a SOD1-peptide immunotherapy on SOD1 G93A mouse slow model of amyotrophic lateral sclerosis.

Sábado J, Casanovas A, Rodrigo H, Arqué G, Esquerda JE.

Neuroscience. 2015 Dec 3;310:38-50. doi: 10.1016/j.neuroscience.2015.09.027. Epub 2015 Sep 15.

PMID:
26384962
3.

Neurotoxic species of misfolded SOD1G93A recognized by antibodies against the P2X4 subunit of the ATP receptor accumulate in damaged neurons of transgenic animal models of amyotrophic lateral sclerosis.

Hernández S, Casanovas A, Piedrafita L, Tarabal O, Esquerda JE.

J Neuropathol Exp Neurol. 2010 Feb;69(2):176-87. doi: 10.1097/NEN.0b013e3181cd3e33.

PMID:
20084016
4.

Heat shock factor 1 over-expression protects against exposure of hydrophobic residues on mutant SOD1 and early mortality in a mouse model of amyotrophic lateral sclerosis.

Lin PY, Simon SM, Koh WK, Folorunso O, Umbaugh CS, Pierce A.

Mol Neurodegener. 2013 Nov 21;8:43. doi: 10.1186/1750-1326-8-43.

7.

Identification of a misfolded region in superoxide dismutase 1 that is exposed in amyotrophic lateral sclerosis.

Rotunno MS, Auclair JR, Maniatis S, Shaffer SA, Agar J, Bosco DA.

J Biol Chem. 2014 Oct 10;289(41):28527-38. doi: 10.1074/jbc.M114.581801. Epub 2014 Aug 27.

8.

Neuregulin 1 confers neuroprotection in SOD1-linked amyotrophic lateral sclerosis mice via restoration of C-boutons of spinal motor neurons.

Lasiene J, Komine O, Fujimori-Tonou N, Powers B, Endo F, Watanabe S, Shijie J, Ravits J, Horner P, Misawa H, Yamanaka K.

Acta Neuropathol Commun. 2016 Feb 18;4:15. doi: 10.1186/s40478-016-0286-7.

9.

A novel monoclonal antibody reveals a conformational alteration shared by amyotrophic lateral sclerosis-linked SOD1 mutants.

Fujisawa T, Homma K, Yamaguchi N, Kadowaki H, Tsuburaya N, Naguro I, Matsuzawa A, Takeda K, Takahashi Y, Goto J, Tsuji S, Nishitoh H, Ichijo H.

Ann Neurol. 2012 Nov;72(5):739-49. doi: 10.1002/ana.23668.

PMID:
23280792
10.

Transcriptional profiling in the lumbar spinal cord of a mouse model of amyotrophic lateral sclerosis: a role for wild-type superoxide dismutase 1 in sporadic disease?

D'Arrigo A, Colavito D, Peña-Altamira E, Fabris M, Dam M, Contestabile A, Leon A.

J Mol Neurosci. 2010 Jul;41(3):404-15. doi: 10.1007/s12031-010-9332-2. Epub 2010 Feb 23. Erratum in: J Mol Neurosci. 2010 Jul;41(3):416.

PMID:
20177826
11.

Superoxide dismutase 1 encoding mutations linked to ALS adopts a spectrum of misfolded states.

Prudencio M, Borchelt DR.

Mol Neurodegener. 2011 Nov 17;6:77. doi: 10.1186/1750-1326-6-77.

12.

Histological evidence of protein aggregation in mutant SOD1 transgenic mice and in amyotrophic lateral sclerosis neural tissues.

Watanabe M, Dykes-Hoberg M, Culotta VC, Price DL, Wong PC, Rothstein JD.

Neurobiol Dis. 2001 Dec;8(6):933-41.

PMID:
11741389
13.

Oral treatment with Cu(II)(atsm) increases mutant SOD1 in vivo but protects motor neurons and improves the phenotype of a transgenic mouse model of amyotrophic lateral sclerosis.

Roberts BR, Lim NK, McAllum EJ, Donnelly PS, Hare DJ, Doble PA, Turner BJ, Price KA, Lim SC, Paterson BM, Hickey JL, Rhoads TW, Williams JR, Kanninen KM, Hung LW, Liddell JR, Grubman A, Monty JF, Llanos RM, Kramer DR, Mercer JF, Bush AI, Masters CL, Duce JA, Li QX, Beckman JS, Barnham KJ, White AR, Crouch PJ.

J Neurosci. 2014 Jun 4;34(23):8021-31. doi: 10.1523/JNEUROSCI.4196-13.2014.

14.

Neuron-specific expression of mutant superoxide dismutase is sufficient to induce amyotrophic lateral sclerosis in transgenic mice.

Jaarsma D, Teuling E, Haasdijk ED, De Zeeuw CI, Hoogenraad CC.

J Neurosci. 2008 Feb 27;28(9):2075-88. doi: 10.1523/JNEUROSCI.5258-07.2008.

15.

The small heat shock protein B8 (HspB8) promotes autophagic removal of misfolded proteins involved in amyotrophic lateral sclerosis (ALS).

Crippa V, Sau D, Rusmini P, Boncoraglio A, Onesto E, Bolzoni E, Galbiati M, Fontana E, Marino M, Carra S, Bendotti C, De Biasi S, Poletti A.

Hum Mol Genet. 2010 Sep 1;19(17):3440-56. doi: 10.1093/hmg/ddq257. Epub 2010 Jun 22.

16.

Targeting of monomer/misfolded SOD1 as a therapeutic strategy for amyotrophic lateral sclerosis.

Liu HN, Tjostheim S, Dasilva K, Taylor D, Zhao B, Rakhit R, Brown M, Chakrabartty A, McLaurin J, Robertson J.

J Neurosci. 2012 Jun 27;32(26):8791-9. doi: 10.1523/JNEUROSCI.5053-11.2012.

17.

Spinal inhibitory interneuron pathology follows motor neuron degeneration independent of glial mutant superoxide dismutase 1 expression in SOD1-ALS mice.

Hossaini M, Cardona Cano S, van Dis V, Haasdijk ED, Hoogenraad CC, Holstege JC, Jaarsma D.

J Neuropathol Exp Neurol. 2011 Aug;70(8):662-77. doi: 10.1097/NEN.0b013e31822581ac.

PMID:
21760539
18.

Proteins that bind to misfolded mutant superoxide dismutase-1 in spinal cords from transgenic amyotrophic lateral sclerosis (ALS) model mice.

Zetterström P, Graffmo KS, Andersen PM, Brännström T, Marklund SL.

J Biol Chem. 2011 Jun 10;286(23):20130-6. doi: 10.1074/jbc.M111.218842. Epub 2011 Apr 14.

19.

Wild-type nonneuronal cells extend survival of SOD1 mutant motor neurons in ALS mice.

Clement AM, Nguyen MD, Roberts EA, Garcia ML, Boillée S, Rule M, McMahon AP, Doucette W, Siwek D, Ferrante RJ, Brown RH Jr, Julien JP, Goldstein LS, Cleveland DW.

Science. 2003 Oct 3;302(5642):113-7. Erratum in: Science. 2003 Oct 24;302(5645):568.

20.

An immunological epitope selective for pathological monomer-misfolded SOD1 in ALS.

Rakhit R, Robertson J, Vande Velde C, Horne P, Ruth DM, Griffin J, Cleveland DW, Cashman NR, Chakrabartty A.

Nat Med. 2007 Jun;13(6):754-9. Epub 2007 May 7.

PMID:
17486090

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