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Items: 1 to 20 of 97

1.

Probe Development Efforts to Identify Novel Inhibitors of ABHD10.

Zuhl AM, Mohr JT, Speers AE, Bachovchin DA, Berlin JM, Spicer T, Fernandez-Vega V, Brown SJ, Ferguson J, Fu GC, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Dec 6 [updated 2013 Mar 7].

2.

Probe Development Efforts to Identify Novel Inhibitors of Protein Phosphatase Methylesterase-1 (PME-1).

Bachovchin DA, Speers AE, Brown SJ, Spicer TP, Fernandez-Vega V, Ferguson J, Mohr JT, Murphy J, Fu GC, Cravatt BF, Hodder PS, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Aug 31 [updated 2011 Dec 12].

3.

Competitive activity-based protein profiling identifies aza-β-lactams as a versatile chemotype for serine hydrolase inhibition.

Zuhl AM, Mohr JT, Bachovchin DA, Niessen S, Hsu KL, Berlin JM, Dochnahl M, López-Alberca MP, Fu GC, Cravatt BF.

J Am Chem Soc. 2012 Mar 21;134(11):5068-71. doi: 10.1021/ja300799t. Epub 2012 Mar 8.

4.

Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

Bachovchin DA, Mohr JT, Speers AE, Wang C, Berlin JM, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Schürer SC, Nomura DK, Rosen H, Fu GC, Cravatt BF.

Proc Natl Acad Sci U S A. 2011 Apr 26;108(17):6811-6. doi: 10.1073/pnas.1015248108. Epub 2011 Mar 11.

5.

Optimization and characterization of a triazole urea inhibitor for alpha/beta hydrolase domain-containing protein 11 (ABHD11): anti-probe for LYPLA1/LYPLA2 dual inhibitor ML211.

Adibekian A, Hsu KL, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Mar 31 [updated 2013 Mar 7].

6.

Optimization and characterization of triazole urea inhibitors for abhydrolase domain containing protein 6 (ABHD6).

Hsu KL, Tsuboi K, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 12 [updated 2013 Mar 14].

7.

Optimization and characterization of a carbamate inhibitor for plasma platelet-activating factor acetylhydrolase (pPAFAH).

Nagano JMG, Hsu KL, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Bahnson BJ, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Nov 30 [updated 2014 May 13].

8.

Optimization and characterization of a triazole urea inhibitor for diacylglycerol lipase beta (DAGL-β).

Hsu KL, Tsuboi K, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2013 Feb 25].

9.

Discovery and optimization of sulfonyl acrylonitriles as selective, covalent inhibitors of protein phosphatase methylesterase-1.

Bachovchin DA, Zuhl AM, Speers AE, Wolfe MR, Weerapana E, Brown SJ, Rosen H, Cravatt BF.

J Med Chem. 2011 Jul 28;54(14):5229-36. doi: 10.1021/jm200502u. Epub 2011 Jun 30.

10.

Optimization and characterization of a triazole urea dual inhibitor for lysophospholipase 1 (LYPLA1) and lysophospholipase 2 (LYPLA2).

Adibekian A, Martin BR, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Feb 25 [updated 2013 Mar 7].

11.

Optimization and characterization of a triazole urea inhibitor for platelet-activating factor acetylhydrolase type 2 (PAFAH2).

Adibekian A, Hsu KL, Speers AE, Monillas ES, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Bahnson BJ, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Mar 31 [updated 2013 Mar 7].

12.

Optimization and Characterization of an Inhibitor for Glutathione S-Tranferase Omega 1 (GSTO1).

Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Aug 31 [updated 2011 Dec 12].

13.

Optimization and characterization of a pan protein arginine deiminase (PAD) inhibitor.

Dreyton CJ, Jones JE, Knuckley BA, Subramanian V, Anderson ED, Brown SJ, Fernandez-Vega V, Eberhart C, Spicer T, Zuhl AM, Ferguson J, Speers AE, Wang C, Boger DL, Thompson P, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Dec 17 [updated 2013 Apr 5].

14.

Click-generated triazole ureas as ultrapotent in vivo-active serine hydrolase inhibitors.

Adibekian A, Martin BR, Wang C, Hsu KL, Bachovchin DA, Niessen S, Hoover H, Cravatt BF.

Nat Chem Biol. 2011 May 15;7(7):469-78. doi: 10.1038/nchembio.579. Erratum in: Nat Chem Biol. 2012 Mar;8(3):318.

15.

ML302, a Novel Beta-lactamase (BLA) Inhibitor.

Spicer T, Minond D, Enogieru I, Saldanha SA, Allais C, Liu Q, Mercer BA, Roush WR, Hodder P.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2014 May 13].

16.

Remodeling natural products: chemistry and serine hydrolase activity of a rocaglate-derived β-lactone.

Lajkiewicz NJ, Cognetta AB 3rd, Niphakis MJ, Cravatt BF, Porco JA Jr.

J Am Chem Soc. 2014 Feb 12;136(6):2659-64. doi: 10.1021/ja412431g. Epub 2014 Feb 4.

17.

Characterization of a Selective, Reversible Inhibitor of Lysophospholipase 2 (LYPLA2).

Adibekian A, Martin BR, Chang JW, Hsu KL, Tsuboi K, Bachovchin DA, Speers AE, Brown SJ, Spicer T, Fernandez-Vega V, Ferguson J, Cravatt BF, Hodder P, Rosen H.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2013 Apr 8 [updated 2014 Sep 18].

18.

Proteome-wide reactivity profiling identifies diverse carbamate chemotypes tuned for serine hydrolase inhibition.

Chang JW, Cognetta AB 3rd, Niphakis MJ, Cravatt BF.

ACS Chem Biol. 2013 Jul 19;8(7):1590-9. doi: 10.1021/cb400261h. Epub 2013 May 23.

19.

Probe Report for PME-1 Inhibitors.

Bachovchin DA, Speers AE, Zuhl AM, Brown SJ, Cravatt BF, Fernandez-Vega V, Spicer T, Mercer BA, Ferguson J, Hodder P, Rosen HR.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Feb 26 [updated 2010 Oct 20].

20.

Oxime esters as selective, covalent inhibitors of the serine hydrolase retinoblastoma-binding protein 9 (RBBP9).

Bachovchin DA, Wolfe MR, Masuda K, Brown SJ, Spicer TP, Fernandez-Vega V, Chase P, Hodder PS, Rosen H, Cravatt BF.

Bioorg Med Chem Lett. 2010 Apr 1;20(7):2254-8. doi: 10.1016/j.bmcl.2010.02.011. Epub 2010 Feb 6.

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