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Items: 1 to 20 of 95

1.

Probing Metabolic Requirements for Fungal Virulence — Probe 1.

Hartland CL, Youngsaye W, Pu J, Vincent B, Mosher CM, Anthoine T, Johnston S, Whitesell L, Dandapani S, Perez J, Munoz B, Palmer M, Lindquist S, Schreiber SL.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2012 Apr 16 [updated 2014 May 14].

2.

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence.

Hartland CL, Youngsaye W, Morgan B, Buhrlage S, Bittker J, Johnston S, Lindquist S, Whitesell L, Vincent B, MacPherson L, Munoz B, Palmer M, Schreiber SL.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2010 Oct 29 [updated 2012 Nov 7].

3.

Identification of small molecules that selectively inhibit fluconazole-resistant Candida albicans in the presence of fluconazole but not in its absence - Probe 2.

Hartland CL, Youngsaye W, Morgan B, Ting A, Nag P, Buhrlage S, Johnston S, Bittker J, Vincent B, Whitesell L, Dandapani S, MacPherson L, Munoz B, Palmer M, Lindquist S, Schreiber SL.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Mar 24 [updated 2011 Dec 12].

4.

Identification of Small Molecules that Selectively Inhibit Fluconazole-Resistant Candida Albicans in the Presence of Fluconazole but not in its Absence - Probe 3.

Hartland CL, Youngsaye W, Dockendorff C, Johnston S, Bittker J, Vincent B, Whitesell L, Dandapani S, MacPherson L, Munoz B, Palmer M, Lindquist S, Schreiber SL.

Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-.
2011 Mar 31 [updated 2011 Nov 21].

5.

Candida and candidaemia. Susceptibility and epidemiology.

Arendrup MC.

Dan Med J. 2013 Nov;60(11):B4698. Review.

PMID:
24192246
6.

Piperazinyl quinolines as chemosensitizers to increase fluconazole susceptibility of Candida albicans clinical isolates.

Youngsaye W, Vincent B, Hartland CL, Morgan BJ, Buhrlage SJ, Johnston S, Bittker JA, MacPherson L, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B.

Bioorg Med Chem Lett. 2011 Sep 15;21(18):5502-5. doi: 10.1016/j.bmcl.2011.06.105. Epub 2011 Jun 30.

7.

ML212: A small-molecule probe for investigating fluconazole resistance mechanisms in Candida albicans.

Youngsaye W, Hartland CL, Morgan BJ, Ting A, Nag PP, Vincent B, Mosher CA, Bittker JA, Dandapani S, Palmer M, Whitesell L, Lindquist S, Schreiber SL, Munoz B.

Beilstein J Org Chem. 2013 Jul 26;9:1501-7. doi: 10.3762/bjoc.9.171. eCollection 2013.

8.

Mitochondrial sorting and assembly machinery subunit Sam37 in Candida albicans: insight into the roles of mitochondria in fitness, cell wall integrity, and virulence.

Qu Y, Jelicic B, Pettolino F, Perry A, Lo TL, Hewitt VL, Bantun F, Beilharz TH, Peleg AY, Lithgow T, Djordjevic JT, Traven A.

Eukaryot Cell. 2012 Apr;11(4):532-44. doi: 10.1128/EC.05292-11. Epub 2012 Jan 27.

9.

An automated high-throughput cell-based multiplexed flow cytometry assay to identify novel compounds to target Candida albicans virulence-related proteins.

Bernardo SM, Allen CP, Waller A, Young SM, Oprea T, Sklar LA, Lee SA.

PLoS One. 2014 Oct 28;9(10):e110354. doi: 10.1371/journal.pone.0110354. eCollection 2014.

10.

Staurosporine Induces Filamentation in the Human Fungal Pathogen Candida albicans via Signaling through Cyr1 and Protein Kinase A.

Xie JL, O'Meara TR, Polvi EJ, Robbins N, Cowen LE.

mSphere. 2017 Mar 1;2(2). pii: e00056-17. doi: 10.1128/mSphere.00056-17. eCollection 2017 Mar-Apr.

11.

Reverse genetics in Candida albicans predicts ARF cycling is essential for drug resistance and virulence.

Epp E, Vanier G, Harcus D, Lee AY, Jansen G, Hallett M, Sheppard DC, Thomas DY, Munro CA, Mullick A, Whiteway M.

PLoS Pathog. 2010 Feb 5;6(2):e1000753. doi: 10.1371/journal.ppat.1000753.

12.

Antifungal activity of redox-active benzaldehydes that target cellular antioxidation.

Kim JH, Chan KL, Mahoney N, Campbell BC.

Ann Clin Microbiol Antimicrob. 2011 May 31;10:23. doi: 10.1186/1476-0711-10-23.

13.

Combination of fluconazole with non-antifungal agents: a promising approach to cope with resistant Candida albicans infections and insight into new antifungal agent discovery.

Liu S, Hou Y, Chen X, Gao Y, Li H, Sun S.

Int J Antimicrob Agents. 2014 May;43(5):395-402. doi: 10.1016/j.ijantimicag.2013.12.009. Epub 2014 Jan 22. Review.

PMID:
24503221
15.

Calcineurin A of Candida albicans: involvement in antifungal tolerance, cell morphogenesis and virulence.

Sanglard D, Ischer F, Marchetti O, Entenza J, Bille J.

Mol Microbiol. 2003 May;48(4):959-76.

16.

Growth inhibitory action of ebselen on fluconazole-resistant Candida albicans: role of the plasma membrane H+-ATPase.

Billack B, Santoro M, Lau-Cam C.

Microb Drug Resist. 2009 Jun;15(2):77-83. doi: 10.1089/mdr.2009.0872.

PMID:
19432523
17.

Central Role of the Trehalose Biosynthesis Pathway in the Pathogenesis of Human Fungal Infections: Opportunities and Challenges for Therapeutic Development.

Thammahong A, Puttikamonkul S, Perfect JR, Brennan RG, Cramer RA.

Microbiol Mol Biol Rev. 2017 Mar 15;81(2). pii: e00053-16. doi: 10.1128/MMBR.00053-16. Print 2017 Jun. Review.

PMID:
28298477
18.

From antidiabetic to antifungal: discovery of highly potent triazole-thiazolidinedione hybrids as novel antifungal agents.

Wu S, Zhang Y, He X, Che X, Wang S, Liu Y, Jiang Y, Liu N, Dong G, Yao J, Miao Z, Wang Y, Zhang W, Sheng C.

ChemMedChem. 2014 Dec;9(12):2639-46. doi: 10.1002/cmdc.201402320. Epub 2014 Sep 5.

PMID:
25196996
19.

Mechanisms of resistance to azole antifungal agents in Candida albicans isolates from AIDS patients involve specific multidrug transporters.

Sanglard D, Kuchler K, Ischer F, Pagani JL, Monod M, Bille J.

Antimicrob Agents Chemother. 1995 Nov;39(11):2378-86.

20.

Candidiasis drug discovery and development: new approaches targeting virulence for discovering and identifying new drugs.

Pierce CG, Lopez-Ribot JL.

Expert Opin Drug Discov. 2013 Sep;8(9):1117-26. doi: 10.1517/17460441.2013.807245. Epub 2013 Jun 6. Review.

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