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Items: 1 to 20 of 86


Variants of insulin-signaling inhibitor genes in type 2 diabetes and related metabolic abnormalities.

de Lorenzo C, Greco A, Fiorentino TV, Mannino GC, Hribal ML.

Int J Genomics. 2013;2013:376454. doi: 10.1155/2013/376454. Epub 2013 May 23.


Is common genetic variation at IRS1, ENPP1 and TRIB3 loci associated with cardiometabolic phenotypes in type 2 diabetes? An exploratory analysis of the Verona Newly Diagnosed Type 2 Diabetes Study (VNDS) 5.

Trombetta M, Dauriz M, Bonetti S, Travia D, Boselli L, Santi L, Bonora E, Bonadonna RC.

Nutr Metab Cardiovasc Dis. 2016 Mar;26(3):232-8. doi: 10.1016/j.numecd.2016.01.002. Epub 2016 Jan 14.


The TRIB3 Q84R polymorphism, insulin resistance and related metabolic alterations.

Prudente S, Trischitta V.

Biochem Soc Trans. 2015 Oct;43(5):1108-11. doi: 10.1042/BST20150115. Review.


The mammalian tribbles homolog TRIB3, glucose homeostasis, and cardiovascular diseases.

Prudente S, Sesti G, Pandolfi A, Andreozzi F, Consoli A, Trischitta V.

Endocr Rev. 2012 Aug;33(4):526-46. doi: 10.1210/er.2011-1042. Epub 2012 May 10. Review.


TRIB3 R84 variant is associated with impaired insulin-mediated nitric oxide production in human endothelial cells.

Andreozzi F, Formoso G, Prudente S, Hribal ML, Pandolfi A, Bellacchio E, Di Silvestre S, Trischitta V, Consoli A, Sesti G.

Arterioscler Thromb Vasc Biol. 2008 Jul;28(7):1355-60. doi: 10.1161/ATVBAHA.108.162883. Epub 2008 Apr 24.


Joint effect of insulin signaling genes on all-cause mortality.

Menzaghi C, Fontana A, Copetti M, Rizza S, Spoto B, Buranasupkajorn P, Tripepi G, Marucci A, Bailetti D, Hastings T, Testa A, Mendonca C, Mallamaci F, De Cosmo S, Bacci S, Federici M, Doria A, Zoccali C, Trischitta V.

Atherosclerosis. 2014 Dec;237(2):639-44. doi: 10.1016/j.atherosclerosis.2014.10.005. Epub 2014 Oct 24.


Infrequent TRIB3 coding variants and coronary artery disease in type 2 diabetes.

Prudente S, Bailetti D, Mendonca C, Mannino GC, Fontana A, Andreozzi F, Hastings T, Mercuri L, Alberico F, Basile G, Copetti M, Sesti G, Doria A, Trischitta V.

Atherosclerosis. 2015 Sep;242(1):334-9. doi: 10.1016/j.atherosclerosis.2015.07.030. Epub 2015 Jul 17.


Genetic variants of the ENPP1/PC-1 gene are associated with hypertriglyceridemia in male subjects.

Tanyolaç S, Bremer AA, Hodoglugil U, Movsesyan I, Pullinger CR, Heiner SW, Malloy MJ, Kane JP, Goldfine ID.

Metab Syndr Relat Disord. 2009 Dec;7(6):543-8. doi: 10.1089/met.2009.0027.


Reduction of protein tyrosine phosphatase 1B increases insulin-dependent signaling in ob/ob mice.

Gum RJ, Gaede LL, Koterski SL, Heindel M, Clampit JE, Zinker BA, Trevillyan JM, Ulrich RG, Jirousek MR, Rondinone CM.

Diabetes. 2003 Jan;52(1):21-8.


Gender differences in the relationship of ENPP1/PC-1 variants to obesity in a Turkish population.

Tanyolaç S, Mahley RW, Hodoglugil U, Goldfine ID.

Obesity (Silver Spring). 2008 Nov;16(11):2468-71. doi: 10.1038/oby.2008.397. Epub 2008 Aug 21.


Joint effect of insulin signaling genes on cardiovascular events and on whole body and endothelial insulin resistance.

Bacci S, Prudente S, Copetti M, Spoto B, Rizza S, Baratta R, Di Pietro N, Morini E, Di Paola R, Testa A, Mallamaci F, Tripepi G, Zhang YY, Mercuri L, Di Silvestre S, Lauro R, Malatino L, Consoli A, Pellegrini F, Pandolfi A, Frittitta L, Zoccali C, Federici M, Doria A, Trischitta V.

Atherosclerosis. 2013 Jan;226(1):140-5. doi: 10.1016/j.atherosclerosis.2012.10.035. Epub 2012 Oct 16.


Lipid phosphatases as a possible therapeutic target in cases of type 2 diabetes and obesity.

Sasaoka T, Wada T, Tsuneki H.

Pharmacol Ther. 2006 Dec;112(3):799-809. Epub 2006 Jul 13. Review.


The ENPP1 K121Q polymorphism is associated with type 2 diabetes and related metabolic phenotypes in a Taiwanese population.

Hsiao TJ, Lin E.

Mol Cell Endocrinol. 2016 Sep 15;433:20-5. doi: 10.1016/j.mce.2016.05.020. Epub 2016 May 26.


Coordinated regulation of insulin signaling by the protein tyrosine phosphatases PTP1B and TCPTP.

Galic S, Hauser C, Kahn BB, Haj FG, Neel BG, Tonks NK, Tiganis T.

Mol Cell Biol. 2005 Jan;25(2):819-29.


Insulin signaling regulating genes: effect on T2DM and cardiovascular risk.

Prudente S, Morini E, Trischitta V.

Nat Rev Endocrinol. 2009 Dec;5(12):682-93. doi: 10.1038/nrendo.2009.215. Review.


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