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STAT4 and T-bet are required for the plasticity of IFN-γ expression across Th2 ontogeny and influence changes in Ifng promoter DNA methylation.

Williams CL, Schilling MM, Cho SH, Lee K, Wei M, Aditi, Boothby M.

J Immunol. 2013 Jul 15;191(2):678-87. doi: 10.4049/jimmunol.1203360. Epub 2013 Jun 12.


Polarized development of memory cell-like IFN-gamma-producing cells in the absence of TCR zeta-chain.

Krymskaya L, Lee WH, Zhong L, Liu CP.

J Immunol. 2005 Feb 1;174(3):1188-95.


Intestinal irradiation and fibrosis in a Th1-deficient environment.

Linard C, Billiard F, Benderitter M.

Int J Radiat Oncol Biol Phys. 2012 Sep 1;84(1):266-73. doi: 10.1016/j.ijrobp.2011.11.027. Epub 2012 Feb 13.


Loss of methylation at the IFNG promoter and CNS-1 is associated with the development of functional IFN-γ memory in human CD4(+) T lymphocytes.

Dong J, Chang HD, Ivascu C, Qian Y, Rezai S, Okhrimenko A, Cosmi L, Maggi L, Eckhardt F, Wu P, Sieper J, Alexander T, Annunziato F, Gossen M, Li J, Radbruch A, Thiel A.

Eur J Immunol. 2013 Mar;43(3):793-804. doi: 10.1002/eji.201242858. Erratum in: Eur J Immunol. 2014 Oct;44(10):3144.


Genetic reprogramming of primary human T cells reveals functional plasticity in Th cell differentiation.

Sundrud MS, Grill SM, Ni D, Nagata K, Alkan SS, Subramaniam A, Unutmaz D.

J Immunol. 2003 Oct 1;171(7):3542-9.


Early transcription and silencing of cytokine genes underlie polarization of T helper cell subsets.

Grogan JL, Mohrs M, Harmon B, Lacy DA, Sedat JW, Locksley RM.

Immunity. 2001 Mar;14(3):205-15.


Synergistic effect of IL-2, IL-12, and IL-18 on thymocyte apoptosis and Th1/Th2 cytokine expression.

Rodriguez-Galán MC, Bream JH, Farr A, Young HA.

J Immunol. 2005 Mar 1;174(5):2796-804.


Regulation of IFN-gamma production by B effector 1 cells: essential roles for T-bet and the IFN-gamma receptor.

Harris DP, Goodrich S, Gerth AJ, Peng SL, Lund FE.

J Immunol. 2005 Jun 1;174(11):6781-90.


T-bet regulates Th1 responses through essential effects on GATA-3 function rather than on IFNG gene acetylation and transcription.

Usui T, Preiss JC, Kanno Y, Yao ZJ, Bream JH, O'Shea JJ, Strober W.

J Exp Med. 2006 Mar 20;203(3):755-66. Epub 2006 Mar 6. Erratum in: J Exp Med. 2006 Apr 17;203(4):1129.


IL-12-induced reversal of human Th2 cells is accompanied by full restoration of IL-12 responsiveness and loss of GATA-3 expression.

Smits HH, van Rietschoten JG, Hilkens CM, Sayilir R, Stiekema F, Kapsenberg ML, Wierenga EA.

Eur J Immunol. 2001 Apr;31(4):1055-65.


Altered Th1 cell differentiation programming by CIITA deficiency.

Patel DR, Kaplan MH, Chang CH.

J Immunol. 2004 Nov 1;173(9):5501-8.


Elevated gene expression of Th1/Th2 associated transcription factors is correlated with disease activity in patients with systemic lupus erythematosus.

Lit LC, Wong CK, Li EK, Tam LS, Lam CW, Lo YM.

J Rheumatol. 2007 Jan;34(1):89-96. Epub 2006 Nov 15.


Stat4 is critical for the balance between Th17 cells and regulatory T cells in colitis.

Xu J, Yang Y, Qiu G, Lal G, Yin N, Wu Z, Bromberg JS, Ding Y.

J Immunol. 2011 Jun 1;186(11):6597-606. doi: 10.4049/jimmunol.1004074. Epub 2011 Apr 27.


Interferons direct Th2 cell reprogramming to generate a stable GATA-3(+)T-bet(+) cell subset with combined Th2 and Th1 cell functions.

Hegazy AN, Peine M, Helmstetter C, Panse I, Fröhlich A, Bergthaler A, Flatz L, Pinschewer DD, Radbruch A, Löhning M.

Immunity. 2010 Jan 29;32(1):116-28. doi: 10.1016/j.immuni.2009.12.004. Epub 2010 Jan 14.


A continuous T-bet expression is required to silence the interleukin-4-producing potential in T helper type 1 cells.

Zhuang Y, Huang Z, Nishida J, Brown M, Zhang L, Huang H.

Immunology. 2009 Sep;128(1):34-42. doi: 10.1111/j.1365-2567.2009.03049.x.


Modular utilization of distal cis-regulatory elements controls Ifng gene expression in T cells activated by distinct stimuli.

Balasubramani A, Shibata Y, Crawford GE, Baldwin AS, Hatton RD, Weaver CT.

Immunity. 2010 Jul 23;33(1):35-47. doi: 10.1016/j.immuni.2010.07.004.

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