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Items: 1 to 20 of 146


Shiga toxin-binding site for host cell receptor GPP130 reveals unexpected divergence in toxin-trafficking mechanisms.

Mukhopadhyay S, Redler B, Linstedt AD.

Mol Biol Cell. 2013 Aug;24(15):2311-8. doi: 10.1091/mbc.E13-01-0057.


A Conserved Structural Motif Mediates Retrograde Trafficking of Shiga Toxin Types 1 and 2.

Selyunin AS, Mukhopadhyay S.

Traffic. 2015 Dec;16(12):1270-87. doi: 10.1111/tra.12338.


Manganese induces oligomerization to promote down-regulation of the intracellular trafficking receptor used by Shiga toxin.

Tewari R, Jarvela T, Linstedt AD.

Mol Biol Cell. 2014 Oct 1;25(19):3049-58. doi: 10.1091/mbc.E14-05-1003.


Manganese blocks intracellular trafficking of Shiga toxin and protects against Shiga toxicosis.

Mukhopadhyay S, Linstedt AD.

Science. 2012 Jan 20;335(6066):332-5. doi: 10.1126/science.1215930.


Comparison of binding platforms yields insights into receptor binding differences between shiga toxins 1 and 2.

Flagler MJ, Mahajan SS, Kulkarni AA, Iyer SS, Weiss AA.

Biochemistry. 2010 Mar 2;49(8):1649-57. doi: 10.1021/bi902084y.


Different roles of the C-terminal end of Stx1A and Stx2A for AB5 complex integrity and retrograde transport of Stx in HeLa cells.

Kymre L, Simm R, Skotland T, Sandvig K.

Pathog Dis. 2015 Dec;73(9):ftv083. doi: 10.1093/femspd/ftv083.


A single VHH-based toxin-neutralizing agent and an effector antibody protect mice against challenge with Shiga toxins 1 and 2.

Tremblay JM, Mukherjee J, Leysath CE, Debatis M, Ofori K, Baldwin K, Boucher C, Peters R, Beamer G, Sheoran A, Bedenice D, Tzipori S, Shoemaker CB.

Infect Immun. 2013 Dec;81(12):4592-603. doi: 10.1128/IAI.01033-13.


Shiga toxin binding to glycolipids and glycans.

Gallegos KM, Conrady DG, Karve SS, Gunasekera TS, Herr AB, Weiss AA.

PLoS One. 2012;7(2):e30368. doi: 10.1371/journal.pone.0030368.


Molecular basis of differential B-pentamer stability of Shiga toxins 1 and 2.

Conrady DG, Flagler MJ, Friedmann DR, Vander Wielen BD, Kovall RA, Weiss AA, Herr AB.

PLoS One. 2010 Dec 28;5(12):e15153. doi: 10.1371/journal.pone.0015153.


The Effects of Shiga Toxin 1, 2 and Their Subunits on Cytokine and Chemokine Expression by Human Macrophage-Like THP-1 Cells.

Brandelli JR, Griener TP, Laing A, Mulvey G, Armstrong GD.

Toxins (Basel). 2015 Oct 9;7(10):4054-66. doi: 10.3390/toxins7104054.


Production of shiga toxin by Escherichia coli measured with reference to the membrane vesicle-associated toxins.

Yokoyama K, Horii T, Yamashino T, Hashikawa S, Barua S, Hasegawa T, Watanabe H, Ohta M.

FEMS Microbiol Lett. 2000 Nov 1;192(1):139-44.


Phylogenetic analysis of Shiga toxin 1 and Shiga toxin 2 genes associated with disease outbreaks.

Lee JE, Reed J, Shields MS, Spiegel KM, Farrell LD, Sheridan PP.

BMC Microbiol. 2007 Dec 4;7:109.


New high-affinity monoclonal antibodies against Shiga toxin 1 facilitate the detection of hybrid Stx1/Stx2 in vivo.

Skinner C, Patfield S, Stanker LH, Fratamico P, He X.

PLoS One. 2014 Jun 10;9(6):e99854. doi: 10.1371/journal.pone.0099854.


Assembly and stability of the shiga toxins investigated by electrospray ionization mass spectrometry.

Kitova EN, Mulvey GL, Dingle T, Sinelnikov I, Wee S, Griener TP, Armstrong GD, Klassen JS.

Biochemistry. 2009 Jun 16;48(23):5365-74. doi: 10.1021/bi9003155.


Entry and killing of Tetrahymena thermophila by bacterially produced Shiga toxin.

Stolfa G, Koudelka GB.

MBio. 2012 Dec 26;4(1):e00416-12. doi: 10.1128/mBio.00416-12.


Structure of shiga toxin type 2 (Stx2) from Escherichia coli O157:H7.

Fraser ME, Fujinaga M, Cherney MM, Melton-Celsa AR, Twiddy EM, O'Brien AD, James MN.

J Biol Chem. 2004 Jun 25;279(26):27511-7. Erratum in: J Biol Chem. 2006 Dec 22;281(51):39740.


Structural analysis of the interaction between Shiga toxin B subunits and linear polymers bearing clustered globotriose residues.

Watanabe M, Igai K, Matsuoka K, Miyagawa A, Watanabe T, Yanoshita R, Samejima Y, Terunuma D, Natori Y, Nishikawa K.

Infect Immun. 2006 Mar;74(3):1984-8.


Genome analysis of a novel Shiga toxin 1 (Stx1)-converting phage which is closely related to Stx2-converting phages but not to other Stx1-converting phages.

Sato T, Shimizu T, Watarai M, Kobayashi M, Kano S, Hamabata T, Takeda Y, Yamasaki S.

J Bacteriol. 2003 Jul;185(13):3966-71.


Shiga toxin 2 is specifically released from bacterial cells by two different mechanisms.

Shimizu T, Ohta Y, Noda M.

Infect Immun. 2009 Jul;77(7):2813-23. doi: 10.1128/IAI.00060-09.


Affinities of Shiga toxins 1 and 2 for univalent and oligovalent Pk-trisaccharide analogs measured by electrospray ionization mass spectrometry.

Kitova EN, Kitov PI, Paszkiewicz E, Kim J, Mulvey GL, Armstrong GD, Bundle DR, Klassen JS.

Glycobiology. 2007 Oct;17(10):1127-37.

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