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Items: 1 to 20 of 95

1.

TNFα cleavage beyond TACE/ADAM17: matrix metalloproteinase 13 is a potential therapeutic target in sepsis and colitis.

Becker-Pauly C, Rose-John S.

EMBO Mol Med. 2013 Jul;5(7):970-2. doi: 10.1002/emmm.201302899. Epub 2013 Jun 11. No abstract available.

2.

Matrix metalloproteinase 13 modulates intestinal epithelial barrier integrity in inflammatory diseases by activating TNF.

Vandenbroucke RE, Dejonckheere E, Van Hauwermeiren F, Lodens S, De Rycke R, Van Wonterghem E, Staes A, Gevaert K, López-Otin C, Libert C.

EMBO Mol Med. 2013 Jul;5(7):1000-16. doi: 10.1002/emmm.201202100. Epub 2013 May 30.

3.

ADAM17, shedding, TACE as therapeutic targets.

Rose-John S.

Pharmacol Res. 2013 May;71:19-22. doi: 10.1016/j.phrs.2013.01.012. Epub 2013 Feb 13. Review.

PMID:
23415892
4.

Release of tumour necrosis factor alpha (TNFalpha) by TNFalpha cleaving enzyme (TACE) in response to septic stimuli in vitro.

Robertshaw HJ, Brennan FM.

Br J Anaesth. 2005 Feb;94(2):222-8. Epub 2004 Nov 19.

PMID:
15556967
5.

ADAM17: a molecular switch to control inflammation and tissue regeneration.

Scheller J, Chalaris A, Garbers C, Rose-John S.

Trends Immunol. 2011 Aug;32(8):380-7. doi: 10.1016/j.it.2011.05.005. Epub 2011 Jul 13. Review.

PMID:
21752713
6.

Microparticles of human atherosclerotic plaques enhance the shedding of the tumor necrosis factor-alpha converting enzyme/ADAM17 substrates, tumor necrosis factor and tumor necrosis factor receptor-1.

Canault M, Leroyer AS, Peiretti F, Lesèche G, Tedgui A, Bonardo B, Alessi MC, Boulanger CM, Nalbone G.

Am J Pathol. 2007 Nov;171(5):1713-23. Epub 2007 Sep 14.

7.

The role of ADAM17 in metabolic inflammation.

Menghini R, Fiorentino L, Casagrande V, Lauro R, Federici M.

Atherosclerosis. 2013 May;228(1):12-7. doi: 10.1016/j.atherosclerosis.2013.01.024. Epub 2013 Jan 25. Review.

PMID:
23384719
8.

Cleavage of pro-tumor necrosis factor alpha by ADAM metallopeptidase domain 17: a fluorescence-based protease assay cleaves its natural protein substrate.

Zhang C, Zheng L, Nurnberg J, Vacari BM, Zhou J, Wang Y.

Anal Biochem. 2014 Jan 15;445:14-9. doi: 10.1016/j.ab.2013.09.022. Epub 2013 Oct 1.

PMID:
24096196
9.

Stroke-induced subventricular zone proliferation is promoted by tumor necrosis factor-alpha-converting enzyme protease activity.

Katakowski M, Chen J, Zhang ZG, Santra M, Wang Y, Chopp M.

J Cereb Blood Flow Metab. 2007 Apr;27(4):669-78. Epub 2006 Aug 23.

PMID:
16926839
10.

TACE inhibition amplifies TNF-alpha-mediated colonic epithelial barrier disruption.

Fréour T, Jarry A, Bach-Ngohou K, Dejoie T, Bou-Hanna C, Denis MG, Mosnier JF, Laboisse CL, Masson D.

Int J Mol Med. 2009 Jan;23(1):41-8.

PMID:
19082505
11.

Protein kinase C (PKC) increases TACE/ADAM17 enzyme activity in porcine ovarian somatic cells, which is essential for granulosa cell luteinization and oocyte maturation.

Yamashita Y, Okamoto M, Ikeda M, Okamoto A, Sakai M, Gunji Y, Nishimura R, Hishinuma M, Shimada M.

Endocrinology. 2014 Mar;155(3):1080-90. doi: 10.1210/en.2013-1655. Epub 2014 Jan 1.

PMID:
24424050
12.

Matrix metalloproteinase-8 plays a pivotal role in neuroinflammation by modulating TNF-α activation.

Lee EJ, Han JE, Woo MS, Shin JA, Park EM, Kang JL, Moon PG, Baek MC, Son WS, Ko YT, Choi JW, Kim HS.

J Immunol. 2014 Sep 1;193(5):2384-93. doi: 10.4049/jimmunol.1303240. Epub 2014 Jul 21.

13.

Tumor necrosis factor signaling requires iRhom2 to promote trafficking and activation of TACE.

Adrain C, Zettl M, Christova Y, Taylor N, Freeman M.

Science. 2012 Jan 13;335(6065):225-8. doi: 10.1126/science.1214400.

14.

Conditional inactivation of TNFα-converting enzyme in chondrocytes results in an elongated growth plate and shorter long bones.

Saito K, Horiuchi K, Kimura T, Mizuno S, Yoda M, Morioka H, Akiyama H, Threadgill D, Okada Y, Toyama Y, Sato K.

PLoS One. 2013;8(1):e54853. doi: 10.1371/journal.pone.0054853. Epub 2013 Jan 18.

15.

Hypoxia-inducible factor mediates hypoxic and tumor necrosis factor alpha-induced increases in tumor necrosis factor-alpha converting enzyme/ADAM17 expression by synovial cells.

Charbonneau M, Harper K, Grondin F, Pelmus M, McDonald PP, Dubois CM.

J Biol Chem. 2007 Nov 16;282(46):33714-24. Epub 2007 Sep 19.

16.

Implication of TNF-alpha convertase (TACE/ADAM17) in inducible nitric oxide synthase expression and inflammation in an experimental model of colitis.

Colón AL, Menchén LA, Hurtado O, De Cristóbal J, Lizasoain I, Leza JC, Lorenzo P, Moro MA.

Cytokine. 2001 Dec 21;16(6):220-6.

PMID:
11884025
17.

Differential expression and regulation of ADAM17 and TIMP3 in acute inflamed intestinal epithelia.

Cesaro A, Abakar-Mahamat A, Brest P, Lassalle S, Selva E, Filippi J, Hébuterne X, Hugot JP, Doglio A, Galland F, Naquet P, Vouret-Craviari V, Mograbi B, Hofman PM.

Am J Physiol Gastrointest Liver Physiol. 2009 Jun;296(6):G1332-43. doi: 10.1152/ajpgi.90641.2008. Epub 2009 Mar 19.

19.

Rosmarinic acid down-regulates endothelial protein C receptor shedding in vitro and in vivo.

Ku SK, Yang EJ, Song KS, Bae JS.

Food Chem Toxicol. 2013 Sep;59:311-5. doi: 10.1016/j.fct.2013.06.003. Epub 2013 Jun 14.

PMID:
23774263
20.

Regulation of peritoneal and systemic neutrophil-derived tumor necrosis factor-alpha release in patients with severe peritonitis: role of tumor necrosis factor-alpha converting enzyme cleavage.

Kermarrec N, Selloum S, Plantefeve G, Chosidow D, Paoletti X, Lopez A, Mantz J, Desmonts JM, Gougerot-Pocidalo MA, Chollet-Martin S.

Crit Care Med. 2005 Jun;33(6):1359-64.

PMID:
15942356

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