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An ethanolic extract of Lindera obtusiloba stems, YJP-14, improves endothelial dysfunction, metabolic parameters and physical performance in diabetic db/db mice.

Lee JO, Auger C, Park DH, Kang M, Oak MH, Kim KR, Schini-Kerth VB.

PLoS One. 2013 Jun 3;8(6):e65227. doi: 10.1371/journal.pone.0065227. Print 2013.


An ethanolic extract of Lindera obtusiloba stems causes NO-mediated endothelium-dependent relaxations in rat aortic rings and prevents angiotensin II-induced hypertension and endothelial dysfunction in rats.

Lee JO, Oak MH, Jung SH, Park DH, Auger C, Kim KR, Lee SW, Schini-Kerth VB.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Jun;383(6):635-45. doi: 10.1007/s00210-011-0643-9. Epub 2011 May 2.


Boldine improves endothelial function in diabetic db/db mice through inhibition of angiotensin II-mediated BMP4-oxidative stress cascade.

Lau YS, Tian XY, Mustafa MR, Murugan D, Liu J, Zhang Y, Lau CW, Huang Y.

Br J Pharmacol. 2013 Nov;170(6):1190-8. doi: 10.1111/bph.12350.


Exercise training improves endothelial function via adiponectin-dependent and independent pathways in type 2 diabetic mice.

Lee S, Park Y, Dellsperger KC, Zhang C.

Am J Physiol Heart Circ Physiol. 2011 Aug;301(2):H306-14. doi: 10.1152/ajpheart.01306.2010. Epub 2011 May 20.


Rosuvastatin improves endothelial function in db/db mice: role of angiotensin II type 1 receptors and oxidative stress.

Tian XY, Wong WT, Xu A, Chen ZY, Lu Y, Liu LM, Lee VW, Lau CW, Yao X, Huang Y.

Br J Pharmacol. 2011 Sep;164(2b):598-606. doi: 10.1111/j.1476-5381.2011.01416.x.


Toll-like receptor 4 mutation protects obese mice against endothelial dysfunction by decreasing NADPH oxidase isoforms 1 and 4.

Liang CF, Liu JT, Wang Y, Xu A, Vanhoutte PM.

Arterioscler Thromb Vasc Biol. 2013 Apr;33(4):777-84. doi: 10.1161/ATVBAHA.112.301087. Epub 2013 Feb 14.


Protective effect of 70% ethanolic extract of Lindera obtusiloba Blume on tert-butyl hydroperoxide-induced oxidative hepatotoxicity in rats.

Hong CO, Rhee CH, Won NH, Choi HD, Lee KW.

Food Chem Toxicol. 2013 Mar;53:214-20. doi: 10.1016/j.fct.2012.11.032. Epub 2012 Dec 2.


The PPARgamma ligand, rosiglitazone, reduces vascular oxidative stress and NADPH oxidase expression in diabetic mice.

Hwang J, Kleinhenz DJ, Rupnow HL, Campbell AG, Thulé PM, Sutliff RL, Hart CM.

Vascul Pharmacol. 2007 Jun;46(6):456-62. Epub 2007 Feb 8.


Resveratrol improves endothelial function: role of TNF{alpha} and vascular oxidative stress.

Zhang H, Zhang J, Ungvari Z, Zhang C.

Arterioscler Thromb Vasc Biol. 2009 Aug;29(8):1164-71. doi: 10.1161/ATVBAHA.109.187146. Epub 2009 May 28.


Angiotensin II type 2 receptor-dependent increase in nitric oxide synthase activity in the endothelium of db/db mice is mediated via a MEK pathway.

Taguchi K, Matsumoto T, Kamata K, Kobayashi T.

Pharmacol Res. 2012 Jul;66(1):41-50. doi: 10.1016/j.phrs.2012.02.010. Epub 2012 Mar 22.


Bone Morphogenic Protein 4 Mediates NOX1-Dependent eNOS Uncoupling, Endothelial Dysfunction, and COX2 Induction in Type 2 Diabetes Mellitus.

Youn JY, Zhou J, Cai H.

Mol Endocrinol. 2015 Aug;29(8):1123-33. doi: 10.1210/ME.2014-1313. Epub 2015 Jun 29.


Anti-diabetic atherosclerosis effect of Prunella vulgaris in db/db mice with type 2 diabetes.

Hwang SM, Kim JS, Lee YJ, Yoon JJ, Lee SM, Kang DG, Lee HS.

Am J Chin Med. 2012;40(5):937-51. doi: 10.1142/S0192415X12500693.


Pioglitazone enhances the blood pressure-lowering effect of losartan via synergistic attenuation of angiotensin II-induced vasoconstriction.

Kong X, Ma MZ, Qin L, Zhang Y, Li XY, Wang GD, Su Q, Zhang DY.

J Renin Angiotensin Aldosterone Syst. 2014 Sep;15(3):259-70. doi: 10.1177/1470320313489061. Epub 2013 May 15.


Pioglitazone ameliorates the lowered exercise capacity and impaired mitochondrial function of the skeletal muscle in type 2 diabetic mice.

Takada S, Hirabayashi K, Kinugawa S, Yokota T, Matsushima S, Suga T, Kadoguchi T, Fukushima A, Homma T, Mizushima W, Masaki Y, Furihata T, Katsuyama R, Okita K, Tsutsui H.

Eur J Pharmacol. 2014 Oct 5;740:690-6. doi: 10.1016/j.ejphar.2014.06.008. Epub 2014 Jun 22.


Exercise restores endothelial function independently of weight loss or hyperglycaemic status in db/db mice.

Moien-Afshari F, Ghosh S, Elmi S, Rahman MM, Sallam N, Khazaei M, Kieffer TJ, Brownsey RW, Laher I.

Diabetologia. 2008 Jul;51(7):1327-37. doi: 10.1007/s00125-008-0996-x. Epub 2008 Apr 25. Erratum in: Diabetologia. 2009 Jan;52(1):181. Elmi, S [added]; Rahman, M M [added]; Sallam, N [added].


The synergistic effect of valsartan and LAF237 [(S)-1-[(3-hydroxy-1-adamantyl)ammo]acetyl-2-cyanopyrrolidine] on vascular oxidative stress and inflammation in type 2 diabetic mice.

Shen M, Sun D, Li W, Liu B, Wang S, Zhang Z, Cao F.

Exp Diabetes Res. 2012;2012:146194. doi: 10.1155/2012/146194. Epub 2012 Mar 15.


Glutathionylation mediates angiotensin II-induced eNOS uncoupling, amplifying NADPH oxidase-dependent endothelial dysfunction.

Galougahi KK, Liu CC, Gentile C, Kok C, Nunez A, Garcia A, Fry NA, Davies MJ, Hawkins CL, Rasmussen HH, Figtree GA.

J Am Heart Assoc. 2014 Apr 22;3(2):e000731. doi: 10.1161/JAHA.113.000731.


Rosiglitazone reverses endothelial dysfunction but not remodeling of femoral artery in Zucker diabetic fatty rats.

Lu X, Guo X, Karathanasis SK, Zimmerman KM, Onyia JE, Peterson RG, Kassab GS.

Cardiovasc Diabetol. 2010 May 19;9:19. doi: 10.1186/1475-2840-9-19.


Differential changes of aorta and carotid vasodilation in type 2 diabetic GK and OLETF rats: paradoxical roles of hyperglycemia and insulin.

Zhong MF, Shen WL, Tabuchi M, Nakamura K, Chen YC, Qiao CZ, He J, Yang J, Zhang C, Kamenov Z, Higashino H, Chen H.

Exp Diabetes Res. 2012;2012:429020. doi: 10.1155/2012/429020. Epub 2011 Oct 1.


An active extract of Lindera obtusiloba inhibits adipogenesis via sustained Wnt signaling and exerts anti-inflammatory effects in the 3T3-L1 preadipocytes.

Freise C, Erben U, Neuman U, Kim K, Zeitz M, Somasundaram R, Ruehl M.

J Nutr Biochem. 2010 Dec;21(12):1170-7. doi: 10.1016/j.jnutbio.2009.09.013. Epub 2010 Jan 25.


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