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Items: 1 to 20 of 149

1.

Water-soluble nitric-oxide-releasing acetylsalicylic acid (ASA) prodrugs.

Rolando B, Lazzarato L, Donnola M, Marini E, Joseph S, Morini G, Pozzoli C, Fruttero R, Gasco A.

ChemMedChem. 2013 Jul;8(7):1199-209. doi: 10.1002/cmdc.201300105. Epub 2013 Jun 10.

PMID:
23754790
2.

Searching for new NO-donor aspirin-like molecules: a new class of nitrooxy-acyl derivatives of salicylic acid.

Lazzarato L, Donnola M, Rolando B, Marini E, Cena C, Coruzzi G, Guaita E, Morini G, Fruttero R, Gasco A, Biondi S, Ongini E.

J Med Chem. 2008 Mar 27;51(6):1894-903. doi: 10.1021/jm701104f. Epub 2008 Feb 23.

PMID:
18293898
3.

Searching for new NO-donor aspirin-like molecules: Furoxanylacyl derivatives of salicylic acid and related furazans.

Lazzarato L, Cena C, Rolando B, Marini E, Lolli ML, Guglielmo S, Guaita E, Morini G, Coruzzi G, Fruttero R, Gasco A.

Bioorg Med Chem. 2011 Oct 1;19(19):5852-60. doi: 10.1016/j.bmc.2011.08.018. Epub 2011 Aug 16.

PMID:
21906954
4.

New nitric oxide or hydrogen sulfide releasing aspirins.

Lazzarato L, Chegaev K, Marini E, Rolando B, Borretto E, Guglielmo S, Joseph S, Di Stilo A, Fruttero R, Gasco A.

J Med Chem. 2011 Aug 11;54(15):5478-84. doi: 10.1021/jm2004514. Epub 2011 Jul 6.

6.
7.

Antiinflammatory, gastrosparing, and antiplatelet properties of new NO-donor esters of aspirin.

Cena C, Lolli ML, Lazzarato L, Guaita E, Morini G, Coruzzi G, McElroy SP, Megson IL, Fruttero R, Gasco A.

J Med Chem. 2003 Feb 27;46(5):747-54.

PMID:
12593655
8.

Comparison between 3-Nitrooxyphenyl acetylsalicylate (NO-ASA) and O2-(acetylsalicyloxymethyl)-1-(pyrrolidin-1-yl)diazen-1-ium-1,2-diolate (NONO-ASA) as safe anti-inflammatory, analgesic, antipyretic, antioxidant prodrugs.

Chattopadhyay M, Velazquez CA, Pruski A, Nia KV, Abdellatif KR, Keefer LK, Kashfi K.

J Pharmacol Exp Ther. 2010 Nov;335(2):443-50. doi: 10.1124/jpet.110.171017. Epub 2010 Aug 2. Erratum in: J Pharmacol Exp Ther. 2010 Dec;335(3):861.

9.

Gastric-sparing nitric oxide-releasable 'true' prodrugs of aspirin and naproxen.

Gund M, Gaikwad P, Borhade N, Burhan A, Desai DC, Sharma A, Dhiman M, Patil M, Sheikh J, Thakre G, Tipparam SG, Sharma S, Nemmani KV, Satyam A.

Bioorg Med Chem Lett. 2014 Dec 15;24(24):5587-92. doi: 10.1016/j.bmcl.2014.10.096. Epub 2014 Nov 5.

PMID:
25466180
10.

Novel azo derivatives as prodrugs of 5-aminosalicylic acid and amino derivatives with potent platelet activating factor antagonist activity.

Carceller E, Salas J, Merlos M, Giral M, Ferrando R, Escamilla I, Ramis J, García-Rafanell J, Forn J.

J Med Chem. 2001 Aug 30;44(18):3001-13.

PMID:
11520209
11.

NO-NSAIDs: Gastric-sparing nitric oxide-releasable prodrugs of non-steroidal anti-inflammatory drugs.

Nemmani KV, Mali SV, Borhade N, Pathan AR, Karwa M, Pamidiboina V, Senthilkumar SP, Gund M, Jain AK, Mangu NK, Dubash NP, Desai DC, Sharma S, Satyam A.

Bioorg Med Chem Lett. 2009 Sep 15;19(18):5297-301. doi: 10.1016/j.bmcl.2009.07.142. Epub 2009 Aug 3.

PMID:
19683923
12.

Evaluation of the in vivo anti-inflammatory and analgesic activity of a highly water-soluble aspirin conjugate.

Jacob JN, Badyal DK, Bala S.

Basic Clin Pharmacol Toxicol. 2013 Mar;112(3):171-4. doi: 10.1111/bcpt.12006. Epub 2012 Oct 9.

13.

Mechanisms of aggregation inhibition by aspirin and nitrate-aspirin prodrugs in human platelets.

Harmon S, Inkielewicz-Stepniak I, Jones M, Ledwidge M, Santos-Martinez MJ, Medina C, Radomski MW, Gilmer JF.

J Pharm Pharmacol. 2012 Jan;64(1):77-89. doi: 10.1111/j.2042-7158.2011.01380.x. Epub 2011 Nov 10.

PMID:
22150675
14.

Dinitroglyceryl and diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of aspirin, indomethacin and ibuprofen: synthesis, biological evaluation and nitric oxide release studies.

Abdellatif KR, Chowdhury MA, Dong Y, Das D, Yu G, Velázquez CA, Suresh MR, Knaus EE.

Bioorg Med Chem Lett. 2009 Jun 1;19(11):3014-8. doi: 10.1016/j.bmcl.2009.04.059. Epub 2009 Apr 20.

PMID:
19419861
17.

Structure, stability, and antiplatelet activity of O-acyl derivatives of salicylic acid and lipophilic esters of acetylsalicylate.

Zavodnik IB, Lapshina E, Sudnikovich E, Boncler M, Luzak B, Rózalski M, Helińska M, Watała C.

Pharmacol Rep. 2009 May-Jun;61(3):476-89.

18.

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 5-(4-hydroxymethylphenyl)-1-(4-aminosulfonylphenyl)-3-trifluoromethyl-1H-pyrazole and its methanesulfonyl analog: synthesis, biological evaluation and nitric oxide release studies.

Abdellatif KR, Chowdhury MA, Dong Y, Velázquez C, Das D, Suresh MR, Knaus EE.

Bioorg Med Chem. 2008 Nov 15;16(22):9694-8. doi: 10.1016/j.bmc.2008.10.001. Epub 2008 Oct 5.

PMID:
18930406
19.

Nitric oxide (NO)-releasing aspirin exhibits a potent esophagoprotection in experimental model of acute reflux esophagitis. Role of nitric oxide and proinflammatory cytokines.

Pawlik M, Pajdo R, Kwiecien S, Ptak-Belowska A, Sliwowski Z, Mazurkiewicz-Janik M, Konturek SJ, Pawlik WW, Brzozowski T.

J Physiol Pharmacol. 2011 Feb;62(1):75-86.

20.

Diazen-1-ium-1,2-diolated nitric oxide donor ester prodrugs of 1-(4-methanesulfonylphenyl)-5-aryl-1H-pyrazol-3-carboxylic acids: synthesis, nitric oxide release studies and anti-inflammatory activities.

Abdellatif KR, Chowdhury MA, Dong Y, Knaus EE.

Bioorg Med Chem. 2008 Jul 1;16(13):6528-34. doi: 10.1016/j.bmc.2008.05.028. Epub 2008 May 17.

PMID:
18513975

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