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APE2 is required for ATR-Chk1 checkpoint activation in response to oxidative stress.

Willis J, Patel Y, Lentz BL, Yan S.

Proc Natl Acad Sci U S A. 2013 Jun 25;110(26):10592-7. doi: 10.1073/pnas.1301445110.


Study of the DNA damage checkpoint using Xenopus egg extracts.

Willis J, DeStephanis D, Patel Y, Gowda V, Yan S.

J Vis Exp. 2012 Nov 5;(69):e4449. doi: 10.3791/4449.


Claspin and the activated form of ATR-ATRIP collaborate in the activation of Chk1.

Kumagai A, Kim SM, Dunphy WG.

J Biol Chem. 2004 Nov 26;279(48):49599-608.


Reconstitution of human claspin-mediated phosphorylation of Chk1 by the ATR (ataxia telangiectasia-mutated and rad3-related) checkpoint kinase.

Lindsey-Boltz LA, Serçin O, Choi JH, Sancar A.

J Biol Chem. 2009 Nov 27;284(48):33107-14. doi: 10.1074/jbc.M109.064485.


Importin β-dependent nuclear import of TopBP1 in ATR-Chk1 checkpoint in Xenopus egg extracts.

Bai L, Michael WM, Yan S.

Cell Signal. 2014 May;26(5):857-67. doi: 10.1016/j.cellsig.2014.01.006.


Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.

Choi JH, Lindsey-Boltz LA, Kemp M, Mason AC, Wold MS, Sancar A.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13660-5. doi: 10.1073/pnas.1007856107.


Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.

Liu S, Opiyo SO, Manthey K, Glanzer JG, Ashley AK, Amerin C, Troksa K, Shrivastav M, Nickoloff JA, Oakley GG.

Nucleic Acids Res. 2012 Nov;40(21):10780-94. doi: 10.1093/nar/gks849.


Opposing effects of the UV lesion repair protein XPA and UV bypass polymerase eta on ATR checkpoint signaling.

Bomgarden RD, Lupardus PJ, Soni DV, Yee MC, Ford JM, Cimprich KA.

EMBO J. 2006 Jun 7;25(11):2605-14. Erratum in: EMBO J. 2006 Oct 18;25(20):5036.


Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

Zou L, Elledge SJ.

Science. 2003 Jun 6;300(5625):1542-8.


Xenopus ATR is a replication-dependent chromatin-binding protein required for the DNA replication checkpoint.

Hekmat-Nejad M, You Z, Yee MC, Newport JW, Cimprich KA.

Curr Biol. 2000 Dec 14-28;10(24):1565-73.


RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.

Lindsey-Boltz LA, Kemp MG, Capp C, Sancar A.

Cell Cycle. 2015;14(1):99-108. doi: 10.4161/15384101.2014.967076.


The structural determinants of checkpoint activation.

MacDougall CA, Byun TS, Van C, Yee MC, Cimprich KA.

Genes Dev. 2007 Apr 15;21(8):898-903.


A role for the MRN complex in ATR activation via TOPBP1 recruitment.

Duursma AM, Driscoll R, Elias JE, Cimprich KA.

Mol Cell. 2013 Apr 11;50(1):116-22. doi: 10.1016/j.molcel.2013.03.006.


Hyperoxia activates the ATR-Chk1 pathway and phosphorylates p53 at multiple sites.

Das KC, Dashnamoorthy R.

Am J Physiol Lung Cell Mol Physiol. 2004 Jan;286(1):L87-97.

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