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Items: 1 to 20 of 94


The natural product honokiol inhibits calcineurin inhibitor-induced and Ras-mediated tumor promoting pathways.

Banerjee P, Basu A, Arbiser JL, Pal S.

Cancer Lett. 2013 Sep 28;338(2):292-9. doi: 10.1016/j.canlet.2013.05.036. Epub 2013 Jun 7.


Calcineurin inhibitors activate the proto-oncogene Ras and promote protumorigenic signals in renal cancer cells.

Datta D, Contreras AG, Basu A, Dormond O, Flynn E, Briscoe DM, Pal S.

Cancer Res. 2009 Dec 1;69(23):8902-9. doi: 10.1158/0008-5472.CAN-09-1404. Epub 2009 Nov 10.


Calcineurin inhibitor-induced and Ras-mediated overexpression of VEGF in renal cancer cells involves mTOR through the regulation of PRAS40.

Basu A, Banerjee P, Contreras AG, Flynn E, Pal S.

PLoS One. 2011;6(8):e23919. doi: 10.1371/journal.pone.0023919. Epub 2011 Aug 23.


The heme oxygenase-1 protein is overexpressed in human renal cancer cells following activation of the Ras-Raf-ERK pathway and mediates anti-apoptotic signal.

Banerjee P, Basu A, Datta D, Gasser M, Waaga-Gasser AM, Pal S.

J Biol Chem. 2011 Sep 23;286(38):33580-90. doi: 10.1074/jbc.M111.248401. Epub 2011 Jul 31.


Effectiveness of a combination therapy using calcineurin inhibitor and mTOR inhibitor in preventing allograft rejection and post-transplantation renal cancer progression.

Basu A, Liu T, Banerjee P, Flynn E, Zurakowski D, Datta D, Viklicky O, Gasser M, Waaga-Gasser AM, Yang J, Pal S.

Cancer Lett. 2012 Aug 28;321(2):179-86. doi: 10.1016/j.canlet.2012.02.004. Epub 2012 Feb 14.


Honokiol suppresses survival signals mediated by Ras-dependent phospholipase D activity in human cancer cells.

Garcia A, Zheng Y, Zhao C, Toschi A, Fan J, Shraibman N, Brown HA, Bar-Sagi D, Foster DA, Arbiser JL.

Clin Cancer Res. 2008 Jul 1;14(13):4267-74. doi: 10.1158/1078-0432.CCR-08-0102.


Calpain/SHP-1 interaction by honokiol dampening peritoneal dissemination of gastric cancer in nu/nu mice.

Liu SH, Wang KB, Lan KH, Lee WJ, Pan HC, Wu SM, Peng YC, Chen YC, Shen CC, Cheng HC, Liao KK, Sheu ML.

PLoS One. 2012;7(8):e43711. doi: 10.1371/journal.pone.0043711. Epub 2012 Aug 24.


The natural product honokiol preferentially inhibits cellular FLICE-inhibitory protein and augments death receptor-induced apoptosis.

Raja SM, Chen S, Yue P, Acker TM, Lefkove B, Arbiser JL, Khuri FR, Sun SY.

Mol Cancer Ther. 2008 Jul;7(7):2212-23. doi: 10.1158/1535-7163.MCT-07-2409.


Honokiol augments the anti-cancer effects of oxaliplatin in colon cancer cells.

Hua H, Chen W, Shen L, Sheng Q, Teng L.

Acta Biochim Biophys Sin (Shanghai). 2013 Sep;45(9):773-9. doi: 10.1093/abbs/gmt071. Epub 2013 Jun 19.


Altered VEGF mRNA stability following treatments with immunosuppressive agents: implications for cancer development.

Basu A, Datta D, Zurakowski D, Pal S.

J Biol Chem. 2010 Aug 13;285(33):25196-202. doi: 10.1074/jbc.M110.119446. Epub 2010 Jun 16.


Novel roles of c-Met in the survival of renal cancer cells through the regulation of HO-1 and PD-L1 expression.

Balan M, Mier y Teran E, Waaga-Gasser AM, Gasser M, Choueiri TK, Freeman G, Pal S.

J Biol Chem. 2015 Mar 27;290(13):8110-20. doi: 10.1074/jbc.M114.612689. Epub 2015 Feb 2.


Honokiol inhibits signal transducer and activator of transcription-3 signaling, proliferation, and survival of hepatocellular carcinoma cells via the protein tyrosine phosphatase SHP-1.

Rajendran P, Li F, Shanmugam MK, Vali S, Abbasi T, Kapoor S, Ahn KS, Kumar AP, Sethi G.

J Cell Physiol. 2012 May;227(5):2184-95. doi: 10.1002/jcp.22954.


Disruption of cooperation between Ras and MycN in human neuroblastoma cells promotes growth arrest.

Yaari S, Jacob-Hirsch J, Amariglio N, Haklai R, Rechavi G, Kloog Y.

Clin Cancer Res. 2005 Jun 15;11(12):4321-30.


Molecular mechanism of inhibition of the abnormal proliferation of human umbilical vein endothelial cells by hydroxysafflor-yellow A.

Wang J, Wang J, Wang X, Liu L, Hu J, Yu X, Xu Y, Niu X, Lin Z, Zhang Y, Zhang X, Zhang Q.

Pharm Biol. 2016 Sep;54(9):1800-7. doi: 10.3109/13880209.2015.1129541. Epub 2016 Jan 5.


Honokiol inhibits H(2)O(2)-induced apoptosis in human lens epithelial cells via inhibition of the mitogen-activated protein kinase and Akt pathways.

Tang X, Yao K, Zhang L, Yang Y, Yao H.

Eur J Pharmacol. 2011 Jan 10;650(1):72-8. doi: 10.1016/j.ejphar.2010.09.076. Epub 2010 Oct 20.


Honokiol inhibits gastric tumourigenesis by activation of 15-lipoxygenase-1 and consequent inhibition of peroxisome proliferator-activated receptor-gamma and COX-2-dependent signals.

Liu SH, Shen CC, Yi YC, Tsai JJ, Wang CC, Chueh JT, Lin KL, Lee TC, Pan HC, Sheu ML.

Br J Pharmacol. 2010 Aug;160(8):1963-72. doi: 10.1111/j.1476-5381.2010.00804.x.


Down-regulation of c-Src/EGFR-mediated signaling activation is involved in the honokiol-induced cell cycle arrest and apoptosis in MDA-MB-231 human breast cancer cells.

Park EJ, Min HY, Chung HJ, Hong JY, Kang YJ, Hung TM, Youn UJ, Kim YS, Bae K, Kang SS, Lee SK.

Cancer Lett. 2009 May 18;277(2):133-40. doi: 10.1016/j.canlet.2008.11.029. Epub 2009 Jan 9.


Overexpression of vascular endothelial growth factor and the development of post-transplantation cancer.

Basu A, Contreras AG, Datta D, Flynn E, Zeng L, Cohen HT, Briscoe DM, Pal S.

Cancer Res. 2008 Jul 15;68(14):5689-98. doi: 10.1158/0008-5472.CAN-07-6603.


Honokiol inhibits tumor necrosis factor-α-stimulated rat aortic smooth muscle cell proliferation via caspase- and mitochondrial-dependent apoptosis.

Fan S, Li X, Lin J, Chen S, Shan J, Qi G.

Inflammation. 2014 Feb;37(1):17-26. doi: 10.1007/s10753-013-9707-y.


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