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Src-inducible association of CrkL with procaspase-8 promotes cell migration.

Graf R, Barbero S, Keller N, Chen L, Uryu S, Schlaepfer D, Stupack D.

Cell Adh Migr. 2013 Jul-Aug;7(4):362-9. doi: 10.4161/cam.25284. Epub 2013 Jun 10.


CrkL is recruited through its SH2 domain to the erythropoietin receptor and plays a role in Lyn-mediated receptor signaling.

Arai A, Kanda E, Nosaka Y, Miyasaka N, Miura O.

J Biol Chem. 2001 Aug 31;276(35):33282-90. Epub 2001 Jul 6.


Tyrosine phosphorylation of the orphan receptor ESDN/DCBLD2 serves as a scaffold for the signaling adaptor CrkL.

Aten TM, Redmond MM, Weaver SO, Love CC, Joy RM, Lapp AS, Rivera OD, Hinkle KL, Ballif BA.

FEBS Lett. 2013 Aug 2;587(15):2313-8. doi: 10.1016/j.febslet.2013.05.064. Epub 2013 Jun 13.


EMT phenotype is induced by increased Src kinase activity via Src-mediated caspase-8 phosphorylation.

Zhao Y, Li X, Sun X, Zhang Y, Ren H.

Cell Physiol Biochem. 2012;29(3-4):341-52. doi: 10.1159/000338489. Epub 2012 Apr 3.


Identification of a critical tyrosine residue in caspase 8 that promotes cell migration.

Barbero S, Barilà D, Mielgo A, Stagni V, Clair K, Stupack D.

J Biol Chem. 2008 May 9;283(19):13031-4. doi: 10.1074/jbc.M800549200. Epub 2008 Jan 23.


Distinct roles for Crk adaptor isoforms in actin reorganization induced by extracellular signals.

Antoku S, Mayer BJ.

J Cell Sci. 2009 Nov 15;122(Pt 22):4228-38. doi: 10.1242/jcs.054627. Epub 2009 Oct 27.


Caspase-8 tyrosine-380 phosphorylation inhibits CD95 DISC function by preventing procaspase-8 maturation and cycling within the complex.

Powley IR, Hughes MA, Cain K, MacFarlane M.

Oncogene. 2016 Oct 27;35(43):5629-5640. doi: 10.1038/onc.2016.99. Epub 2016 Apr 25.


Migration of sympathetic preganglionic neurons in the spinal cord is regulated by Reelin-dependent Dab1 tyrosine phosphorylation and CrkL.

Yip YP, Kronstadt-O'Brien P, Capriotti C, Cooper JA, Yip JW.

J Comp Neurol. 2007 Jun 1;502(4):635-43.


Evidence for in vivo phosphorylation of the Grb2 SH2-domain binding site on focal adhesion kinase by Src-family protein-tyrosine kinases.

Schlaepfer DD, Hunter T.

Mol Cell Biol. 1996 Oct;16(10):5623-33. Erratum in: Mol Cell Biol 1996 Dec;16(12):7182-4.


Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway.

Park TJ, Curran T.

J Neurosci. 2008 Dec 10;28(50):13551-62. doi: 10.1523/JNEUROSCI.4323-08.2008.


MUC1 initiates Src-CrkL-Rac1/Cdc42-mediated actin cytoskeletal protrusive motility after ligating intercellular adhesion molecule-1.

Shen Q, Rahn JJ, Zhang J, Gunasekera N, Sun X, Shaw AR, Hendzel MJ, Hoffman P, Bernier A, Hugh JC.

Mol Cancer Res. 2008 Apr;6(4):555-67. doi: 10.1158/1541-7786.MCR-07-2033.


The overexpression of scaffolding protein NEDD9 promotes migration and invasion in cervical cancer via tyrosine phosphorylated FAK and SRC.

Sima N, Cheng X, Ye F, Ma D, Xie X, Lü W.

PLoS One. 2013 Sep 18;8(9):e74594. doi: 10.1371/journal.pone.0074594. eCollection 2013.


Crk adaptor protein-induced phosphorylation of Gab1 on tyrosine 307 via Src is important for organization of focal adhesions and enhanced cell migration.

Watanabe T, Tsuda M, Makino Y, Konstantinou T, Nishihara H, Majima T, Minami A, Feller SM, Tanaka S.

Cell Res. 2009 May;19(5):638-50. doi: 10.1038/cr.2009.40.


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