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In the absence of RidA, endogenous 2-aminoacrylate inactivates alanine racemases by modifying the pyridoxal 5'-phosphate cofactor.

Flynn JM, Downs DM.

J Bacteriol. 2013 Aug;195(16):3603-9. doi: 10.1128/JB.00463-13. Epub 2013 Jun 7.


Endogenous synthesis of 2-aminoacrylate contributes to cysteine sensitivity in Salmonella enterica.

Ernst DC, Lambrecht JA, Schomer RA, Downs DM.

J Bacteriol. 2014 Sep;196(18):3335-42. doi: 10.1128/JB.01960-14. Epub 2014 Jul 7.


RidA proteins prevent metabolic damage inflicted by PLP-dependent dehydratases in all domains of life.

Lambrecht JA, Schmitz GE, Downs DM.

MBio. 2013 Feb 5;4(1):e00033-13. doi: 10.1128/mBio.00033-13.


2-Aminoacrylate Stress Induces a Context-Dependent Glycine Requirement in ridA Strains of Salmonella enterica.

Ernst DC, Downs DM.

J Bacteriol. 2015 Nov 16;198(3):536-43. doi: 10.1128/JB.00804-15.


Genomic and experimental evidence for multiple metabolic functions in the RidA/YjgF/YER057c/UK114 (Rid) protein family.

Niehaus TD, Gerdes S, Hodge-Hanson K, Zhukov A, Cooper AJ, ElBadawi-Sidhu M, Fiehn O, Downs DM, Hanson AD.

BMC Genomics. 2015 May 15;16:382. doi: 10.1186/s12864-015-1584-3.


Decreased coenzyme A levels in ridA mutant strains of Salmonella enterica result from inactivated serine hydroxymethyltransferase.

Flynn JM, Christopherson MR, Downs DM.

Mol Microbiol. 2013 Aug;89(4):751-9. doi: 10.1111/mmi.12313. Epub 2013 Jul 19.


From microbiology to cancer biology: the Rid protein family prevents cellular damage caused by endogenously generated reactive nitrogen species.

Downs DM, Ernst DC.

Mol Microbiol. 2015 Apr;96(2):211-9. doi: 10.1111/mmi.12945. Epub 2015 Feb 26. Review.


Suppressor analyses identify threonine as a modulator of ridA mutant phenotypes in Salmonella enterica.

Christopherson MR, Lambrecht JA, Downs D, Downs DM.

PLoS One. 2012;7(8):e43082. doi: 10.1371/journal.pone.0043082. Epub 2012 Aug 10.


Conserved YjgF protein family deaminates reactive enamine/imine intermediates of pyridoxal 5'-phosphate (PLP)-dependent enzyme reactions.

Lambrecht JA, Flynn JM, Downs DM.

J Biol Chem. 2012 Jan 27;287(5):3454-61. doi: 10.1074/jbc.M111.304477. Epub 2011 Nov 17.


Crystal structures of RidA, an important enzyme for the prevention of toxic side products.

Liu X, Zeng J, Chen X, Xie W.

Sci Rep. 2016 Jul 26;6:30494. doi: 10.1038/srep30494.


Members of the YjgF/YER057c/UK114 family of proteins inhibit phosphoribosylamine synthesis in vitro.

Lambrecht JA, Browne BA, Downs DM.

J Biol Chem. 2010 Nov 5;285(45):34401-7. doi: 10.1074/jbc.M110.160515. Epub 2010 Sep 3.


Conversion of a PLP-dependent racemase into an aldolase by a single active site mutation.

Seebeck FP, Hilvert D.

J Am Chem Soc. 2003 Aug 27;125(34):10158-9.


Structure of alanine racemase from Oenococcus oeni with bound pyridoxal 5'-phosphate.

Palani K, Burley SK, Swaminathan S.

Acta Crystallogr Sect F Struct Biol Cryst Commun. 2013 Jan 1;69(Pt 1):15-9. doi: 10.1107/S1744309112047276. Epub 2012 Dec 25.


[Cloning, sequence analysis and expression of alanine racemase gene in Pseudomonas putida].

Cao Q, Zhao Z, Zhang YZ, Wang Y, Ding JY.

Wei Sheng Wu Xue Bao. 2006 Feb;46(1):80-4. Chinese.


Expression of alr gene from Corynebacterium glutamicum ATCC 13032 in Escherichia coli and molecular characterization of the recombinant alanine racemase.

Oikawa T, Tauch A, Schaffer S, Fujioka T.

J Biotechnol. 2006 Oct 1;125(4):503-12. Epub 2006 May 16.


Role of the pyridine nitrogen in pyridoxal 5'-phosphate catalysis: activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5'-phosphate.

Griswold WR, Toney MD.

J Am Chem Soc. 2011 Sep 21;133(37):14823-30. doi: 10.1021/ja2061006. Epub 2011 Aug 24.


Upregulation of MetC is essential for D-alanine-independent growth of an alr/dadX-deficient Escherichia coli strain.

Kang L, Shaw AC, Xu D, Xia W, Zhang J, Deng J, W├Âldike HF, Liu Y, Su J.

J Bacteriol. 2011 Mar;193(5):1098-106. doi: 10.1128/JB.01027-10. Epub 2010 Dec 30.

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