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Repression of miR-143 mediates Cr (VI)-induced tumor angiogenesis via IGF-IR/IRS1/ERK/IL-8 pathway.

He J, Qian X, Carpenter R, Xu Q, Wang L, Qi Y, Wang ZX, Liu LZ, Jiang BH.

Toxicol Sci. 2013 Jul;134(1):26-38. doi: 10.1093/toxsci/kft101. Epub 2013 Jun 7.


Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways.

Pratheeshkumar P, Son YO, Divya SP, Roy RV, Hitron JA, Wang L, Kim D, Dai J, Asha P, Zhang Z, Wang Y, Shi X.

Toxicol Appl Pharmacol. 2014 Dec 1;281(2):230-41. doi: 10.1016/j.taap.2014.10.008. Epub 2014 Oct 23.


Activation of Epidermal Growth Factor Receptor/p38/Hypoxia-inducible Factor-1α Is Pivotal for Angiogenesis and Tumorigenesis of Malignantly Transformed Cells Induced by Hexavalent Chromium.

Kim D, Dai J, Park YH, Fai LY, Wang L, Pratheeshkumar P, Son YO, Kondo K, Xu M, Luo J, Shi X, Zhang Z.

J Biol Chem. 2016 Jul 29;291(31):16271-81. doi: 10.1074/jbc.M116.715797. Epub 2016 May 25.


Epithelial-mesenchymal transition during oncogenic transformation induced by hexavalent chromium involves reactive oxygen species-dependent mechanism in lung epithelial cells.

Ding SZ, Yang YX, Li XL, Michelli-Rivera A, Han SY, Wang L, Pratheeshkumar P, Wang X, Lu J, Yin YQ, Budhraja A, Hitron AJ.

Toxicol Appl Pharmacol. 2013 May 15;269(1):61-71. doi: 10.1016/j.taap.2013.03.006. Epub 2013 Mar 19.


Gene 33/Mig6 inhibits hexavalent chromium-induced DNA damage and cell transformation in human lung epithelial cells.

Park S, Li C, Zhao H, Darzynkiewicz Z, Xu D.

Oncotarget. 2016 Feb 23;7(8):8916-30. doi: 10.18632/oncotarget.6866.


Human bronchial epithelial BEAS-2B cells, an appropriate in vitro model to study heavy metals induced carcinogenesis.

Park YH, Kim D, Dai J, Zhang Z.

Toxicol Appl Pharmacol. 2015 Sep 15;287(3):240-5. doi: 10.1016/j.taap.2015.06.008. Epub 2015 Jun 17.


Hexavalent Chromium (Cr(VI)) Down-Regulates Acetylation of Histone H4 at Lysine 16 through Induction of Stressor Protein Nupr1.

Chen D, Kluz T, Fang L, Zhang X, Sun H, Jin C, Costa M.

PLoS One. 2016 Jun 10;11(6):e0157317. doi: 10.1371/journal.pone.0157317. eCollection 2016.


Multifunctional role of Bcl-2 in malignant transformation and tumorigenesis of Cr(VI)-transformed lung cells.

Medan D, Luanpitpong S, Azad N, Wang L, Jiang BH, Davis ME, Barnett JB, Guo L, Rojanasakul Y.

PLoS One. 2012;7(5):e37045. doi: 10.1371/journal.pone.0037045. Epub 2012 May 29.


Protection from Cr(VI)-induced malignant cell transformation and tumorigenesis of Cr(VI)-transformed cells by luteolin through Nrf2 signaling.

Son YO, Pratheeshkumar P, Wang Y, Kim D, Zhang Z, Shi X.

Toxicol Appl Pharmacol. 2017 Sep 15;331:24-32. doi: 10.1016/j.taap.2017.04.016. Epub 2017 Apr 14.


NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium.

Wang X, Son YO, Chang Q, Sun L, Hitron JA, Budhraja A, Zhang Z, Ke Z, Chen F, Luo J, Shi X.

Toxicol Sci. 2011 Oct;123(2):399-410. doi: 10.1093/toxsci/kfr180. Epub 2011 Jul 8.


A regulatory circuit of miR-148a/152 and DNMT1 in modulating cell transformation and tumor angiogenesis through IGF-IR and IRS1.

Xu Q, Jiang Y, Yin Y, Li Q, He J, Jing Y, Qi YT, Xu Q, Li W, Lu B, Peiper SS, Jiang BH, Liu LZ.

J Mol Cell Biol. 2013 Feb;5(1):3-13. doi: 10.1093/jmcb/mjs049. Epub 2012 Aug 29.


Hexavalent chromium induces malignant transformation of human lung bronchial epithelial cells via ROS-dependent activation of miR-21-PDCD4 signaling.

Pratheeshkumar P, Son YO, Divya SP, Turcios L, Roy RV, Hitron JA, Wang L, Kim D, Dai J, Asha P, Zhang Z, Shi X.

Oncotarget. 2016 Aug 9;7(32):51193-51210. doi: 10.18632/oncotarget.9967.


Nitric oxide-mediated bcl-2 stabilization potentiates malignant transformation of human lung epithelial cells.

Azad N, Iyer AK, Wang L, Lu Y, Medan D, Castranova V, Rojanasakul Y.

Am J Respir Cell Mol Biol. 2010 May;42(5):578-85. doi: 10.1165/rcmb.2009-0094OC. Epub 2009 Jun 25.


Comparison of gene expression profiles in chromate transformed BEAS-2B cells.

Sun H, Clancy HA, Kluz T, Zavadil J, Costa M.

PLoS One. 2011 Mar 18;6(3):e17982. doi: 10.1371/journal.pone.0017982.


Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development.

Kim D, Dai J, Fai LY, Yao H, Son YO, Wang L, Pratheeshkumar P, Kondo K, Shi X, Zhang Z.

J Biol Chem. 2015 Jan 23;290(4):2213-24. doi: 10.1074/jbc.M114.619783. Epub 2014 Dec 4.


Induction of pro-apoptotic and cell cycle-inhibiting genes in chromium (VI)-treated human lung fibroblasts: lack of effect of ERK.

Ceryak S, Zingariello C, O'Brien T, Patierno SR.

Mol Cell Biochem. 2004 Jan;255(1-2):139-49.


Molecular mechanisms of hexavalent chromium-induced apoptosis in human bronchoalveolar cells.

Russo P, Catassi A, Cesario A, Imperatori A, Rotolo N, Fini M, Granone P, Dominioni L.

Am J Respir Cell Mol Biol. 2005 Dec;33(6):589-600. Epub 2005 Sep 15.


Loss of fructose-1,6-bisphosphatase induces glycolysis and promotes apoptosis resistance of cancer stem-like cells: an important role in hexavalent chromium-induced carcinogenesis.

Dai J, Ji Y, Wang W, Kim D, Fai LY, Wang L, Luo J, Zhang Z.

Toxicol Appl Pharmacol. 2017 Sep 15;331:164-173. doi: 10.1016/j.taap.2017.06.014. Epub 2017 Jun 15.


Assessment of the mode of action for hexavalent chromium-induced lung cancer following inhalation exposures.

Proctor DM, Suh M, Campleman SL, Thompson CM.

Toxicology. 2014 Nov 5;325:160-79. doi: 10.1016/j.tox.2014.08.009. Epub 2014 Aug 28. Review.


Cadmium increases HIF-1 and VEGF expression through ROS, ERK, and AKT signaling pathways and induces malignant transformation of human bronchial epithelial cells.

Jing Y, Liu LZ, Jiang Y, Zhu Y, Guo NL, Barnett J, Rojanasakul Y, Agani F, Jiang BH.

Toxicol Sci. 2012 Jan;125(1):10-9. doi: 10.1093/toxsci/kfr256. Epub 2011 Oct 9.

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