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Items: 1 to 20 of 90

1.

Synthesis, structure-property relationships and pharmacokinetic evaluation of ethyl 6-aminonicotinate sulfonylureas as antagonists of the P2Y₁₂ receptor.

Bach P, Boström J, Brickmann K, van Giezen JJ, Groneberg RD, Harvey DM, O'Sullivan M, Zetterberg F.

Eur J Med Chem. 2013 Jul;65:360-75. doi: 10.1016/j.ejmech.2013.04.007. Epub 2013 May 15.

PMID:
23747805
2.

A novel series of piperazinyl-pyridine ureas as antagonists of the purinergic P2Y12 receptor.

Bach P, Boström J, Brickmann K, van Giezen JJ, Hovland R, Petersson AU, Ray A, Zetterberg F.

Bioorg Med Chem Lett. 2011 May 15;21(10):2877-81. doi: 10.1016/j.bmcl.2011.03.088. Epub 2011 Mar 30.

PMID:
21507636
3.

Identification of high-affinity P2Y₁₂ antagonists based on a phenylpyrazole glutamic acid piperazine backbone.

Zech G, Hessler G, Evers A, Weiss T, Florian P, Just M, Czech J, Czechtizky W, Görlitzer J, Ruf S, Kohlmann M, Nazaré M.

J Med Chem. 2012 Oct 25;55(20):8615-29. doi: 10.1021/jm300771j. Epub 2012 Oct 4.

PMID:
22984835
4.
5.

Synthesis and biological evaluation of ticagrelor derivatives as novel antiplatelet agents.

Zhang H, Liu J, Zhang L, Kong L, Yao H, Sun H.

Bioorg Med Chem Lett. 2012 Jun 1;22(11):3598-602. doi: 10.1016/j.bmcl.2012.04.050. Epub 2012 Apr 16.

PMID:
22546677
6.

Synthesis and biological evaluation of cyclopentyl-triazolol-pyrimidine (CPTP) based P2Y12 antagonists.

Tu W, Fan J, Zhang H, Xu G, Liu Z, Qu J, Yang F, Zhang L, Luan T, Yuan J, Gong A, Feng J, Sun P, Dong Q.

Bioorg Med Chem Lett. 2014 Jan 1;24(1):141-6. doi: 10.1016/j.bmcl.2013.11.055. Epub 2013 Dec 1.

PMID:
24332627
7.

Discovery of diarylurea P2Y(1) antagonists with improved aqueous solubility.

Wang TC, Qiao JX, Clark CG, Jua J, Price LA, Wu Q, Chang M, Zheng J, Huang CS, Everlof G, Schumacher WA, Wong PC, Seiffert DA, Stewart AB, Bostwick JS, Crain EJ, Watson CA, Rehfuss R, Wexler RR, Lam PY.

Bioorg Med Chem Lett. 2013 Jun 1;23(11):3239-43. doi: 10.1016/j.bmcl.2013.03.125. Epub 2013 Apr 6.

PMID:
23602442
8.

5-alkyl-1,3-oxazole derivatives of 6-amino-nicotinic acids as alkyl ester bioisosteres are antagonists of the P2Y12 receptor.

Bach P, Boström J, Brickmann K, Burgess LE, Clarke D, Groneberg RD, Harvey DM, Laird ER, O'Sullivan M, Zetterberg F.

Future Med Chem. 2013 Nov;5(17):2037-56. doi: 10.4155/fmc.13.171.

PMID:
24215345
9.

Benzofuran-substituted urea derivatives as novel P2Y(1) receptor antagonists.

Thalji RK, Aiyar N, Davenport EA, Erhardt JA, Kallal LA, Morrow DM, Senadhi S, Burns-Kurtis CL, Marino JP Jr.

Bioorg Med Chem Lett. 2010 Jul 15;20(14):4104-7. doi: 10.1016/j.bmcl.2010.05.072. Epub 2010 Jun 9.

PMID:
20542694
10.

Discovery of 2-(phenoxypyridine)-3-phenylureas as small molecule P2Y1 antagonists.

Chao H, Turdi H, Herpin TF, Roberge JY, Liu Y, Schnur DM, Poss MA, Rehfuss R, Hua J, Wu Q, Price LA, Abell LM, Schumacher WA, Bostwick JS, Steinbacher TE, Stewart AB, Ogletree ML, Huang CS, Chang M, Cacace AM, Arcuri MJ, Celani D, Wexler RR, Lawrence RM.

J Med Chem. 2013 Feb 28;56(4):1704-14. doi: 10.1021/jm301708u. Epub 2013 Feb 18.

PMID:
23368907
11.

Combined 3D-QSAR, molecular docking, and molecular dynamics study on piperazinyl-glutamate-pyridines/pyrimidines as potent P2Y12 antagonists for inhibition of platelet aggregation.

Hao M, Li Y, Wang Y, Yan Y, Zhang S, Li G, Yang L.

J Chem Inf Model. 2011 Oct 24;51(10):2560-72. doi: 10.1021/ci2002878. Epub 2011 Sep 29. Erratum in: J Chem Inf Model. 2011 Nov 28;51(11):3027. Li, Guohui [added]; Yang, Ling [added].

PMID:
21923153
12.

New azole antagonists with high affinity for the P2Y(1) receptor.

Ruel R, L'Heureux A, Thibeault C, Daris JP, Martel A, Price LA, Wu Q, Hua J, Wexler RR, Rehfuss R, Lam PY.

Bioorg Med Chem Lett. 2013 Jun 15;23(12):3519-22. doi: 10.1016/j.bmcl.2013.04.041. Epub 2013 Apr 25.

PMID:
23668989
13.

Identification of 1-{2-[4-chloro-1'-(2,2-dimethylpropyl)-7-hydroxy-1,2-dihydrospiro[indole-3,4'-piperidine]-1-yl]phenyl}-3-{5-chloro-[1,3]thiazolo[5,4-b]pyridin-2-yl}urea, a potent, efficacious and orally bioavailable P2Y(1) antagonist as an antiplatelet agent.

Jeon YT, Yang W, Qiao JX, Li L, Ruel R, Thibeault C, Hiebert S, Wang TC, Wang Y, Liu Y, Clark CG, Wong HS, Zhu J, Wu DR, Sun D, Chen BC, Mathur A, Chacko SA, Malley M, Chen XQ, Shen H, Huang CS, Schumacher WA, Bostwick JS, Stewart AB, Price LA, Hua J, Li D, Levesque PC, Seiffert DA, Rehfuss R, Wexler RR, Lam PY.

Bioorg Med Chem Lett. 2014 Mar 1;24(5):1294-8. doi: 10.1016/j.bmcl.2014.01.066. Epub 2014 Jan 31.

PMID:
24513044
14.

State of affairs: Design and structure-activity relationships of reversible P2Y12 receptor antagonists.

Zetterberg F, Svensson P.

Bioorg Med Chem Lett. 2016 Jun 15;26(12):2739-54. doi: 10.1016/j.bmcl.2016.04.030. Epub 2016 Apr 13. Review.

PMID:
27133596
15.

2-Aminothiazole based P2Y(1) antagonists as novel antiplatelet agents.

Pi Z, Sutton J, Lloyd J, Hua J, Price L, Wu Q, Chang M, Zheng J, Rehfuss R, Huang CS, Wexler RR, Lam PY.

Bioorg Med Chem Lett. 2013 Jul 15;23(14):4206-9. doi: 10.1016/j.bmcl.2013.05.025. Epub 2013 May 17.

PMID:
23743287
16.

Molecular mechanism of action for reversible P2Y12 antagonists.

Liu H, Ge H, Peng Y, Xiao P, Xu J.

Biophys Chem. 2011 May;155(2-3):74-81. doi: 10.1016/j.bpc.2011.03.001. Epub 2011 Mar 6.

PMID:
21440362
17.

Docking-based virtual screening of potential human P2Y12 receptor antagonists.

Chen H, Dong X, Zhou M, Shi H, Luo X.

Acta Biochim Biophys Sin (Shanghai). 2011 May;43(5):400-8. doi: 10.1093/abbs/gmr023. Epub 2011 Apr 7.

PMID:
21474491
18.

Sulfonylureas and sulfonylcarbamates as new non-tetrazole angiotensin II receptor antagonists. Discovery of a highly potent orally active (imidazolylbiphenylyl)sulfonylurea (HR 720).

Deprez P, Guillaume J, Becker R, Corbier A, Didierlaurent S, Fortin M, Frechet D, Hamon G, Heckmann B, Heitsch H, et al.

J Med Chem. 1995 Jun 23;38(13):2357-77.

PMID:
7608902
19.

Potent P2Y1 urea antagonists bearing various cyclic amine scaffolds.

Ruel R, L'Heureux A, Thibeault C, Lapointe P, Martel A, Qiao JX, Hua J, Price LA, Wu Q, Chang M, Zheng J, Huang CS, Wexler RR, Rehfuss R, Lam PY.

Bioorg Med Chem Lett. 2013 Dec 15;23(24):6825-8. doi: 10.1016/j.bmcl.2013.10.009. Epub 2013 Oct 11.

PMID:
24269480
20.

Functional interaction between purinergic receptors: effect of ligands for A2A and P2Y12 receptors on P2Y1 receptor function.

Suzuki T, Obara Y, Moriya T, Nakata H, Nakahata N.

FEBS Lett. 2011 Dec 15;585(24):3978-84. doi: 10.1016/j.febslet.2011.10.050. Epub 2011 Nov 10.

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