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Items: 1 to 20 of 146


Complement component C3 plays a critical role in protecting the aging retina in a murine model of age-related macular degeneration.

Hoh Kam J, Lenassi E, Malik TH, Pickering MC, Jeffery G.

Am J Pathol. 2013 Aug;183(2):480-92. doi: 10.1016/j.ajpath.2013.04.008. Epub 2013 Jun 6.


Systemic administration of Abeta mAb reduces retinal deposition of Abeta and activated complement C3 in age-related macular degeneration mouse model.

Catchpole I, Germaschewski V, Hoh Kam J, Lundh von Leithner P, Ford S, Gough G, Adamson P, Overend P, Hilpert J, López FJ, Ng YS, Coffey P, Jeffery G.

PLoS One. 2013 Jun 14;8(6):e65518. doi: 10.1371/journal.pone.0065518. Print 2013.


Expression of complement component 3 (C3) from an adenovirus leads to pathology in the murine retina.

Cashman SM, Desai A, Ramo K, Kumar-Singh R.

Invest Ophthalmol Vis Sci. 2011 May 18;52(6):3436-45. doi: 10.1167/iovs.10-6002.


Expression of human complement factor H prevents age-related macular degeneration-like retina damage and kidney abnormalities in aged Cfh knockout mice.

Ding JD, Kelly U, Landowski M, Toomey CB, Groelle M, Miller C, Smith SG, Klingeborn M, Singhapricha T, Jiang H, Frank MM, Bowes Rickman C.

Am J Pathol. 2015 Jan;185(1):29-42. doi: 10.1016/j.ajpath.2014.08.026. Epub 2014 Nov 1.


Amyloid beta deposition and phosphorylated tau accumulation are key features in aged choroidal vessels in the complement factor H knock out model of retinal degeneration.

Aboelnour A, Kam JH, Elnasharty MA, Sayed-Ahmed A, Jeffery G.

Exp Eye Res. 2016 Jun;147:138-43. doi: 10.1016/j.exer.2016.05.015. Epub 2016 May 12.


Complement factor H deficiency in aged mice causes retinal abnormalities and visual dysfunction.

Coffey PJ, Gias C, McDermott CJ, Lundh P, Pickering MC, Sethi C, Bird A, Fitzke FW, Maass A, Chen LL, Holder GE, Luthert PJ, Salt TE, Moss SE, Greenwood J.

Proc Natl Acad Sci U S A. 2007 Oct 16;104(42):16651-6. Epub 2007 Oct 5.


Complement factor H deficiency results in decreased neuroretinal expression of Cd59a in aged mice.

Faber C, Williams J, Juel HB, Greenwood J, Nissen MH, Moss SE.

Invest Ophthalmol Vis Sci. 2012 Sep 19;53(10):6324-30.


Impaired binding of the age-related macular degeneration-associated complement factor H 402H allotype to Bruch's membrane in human retina.

Clark SJ, Perveen R, Hakobyan S, Morgan BP, Sim RB, Bishop PN, Day AJ.

J Biol Chem. 2010 Sep 24;285(39):30192-202. doi: 10.1074/jbc.M110.103986. Epub 2010 Jul 26.


Bisretinoid-mediated complement activation on retinal pigment epithelial cells is dependent on complement factor H haplotype.

Radu RA, Hu J, Jiang Z, Bok D.

J Biol Chem. 2014 Mar 28;289(13):9113-20. doi: 10.1074/jbc.M114.548669. Epub 2014 Feb 18.


Synthesis of complement factor H by retinal pigment epithelial cells is down-regulated by oxidized photoreceptor outer segments.

Chen M, Forrester JV, Xu H.

Exp Eye Res. 2007 Apr;84(4):635-45. Epub 2006 Dec 31.


Regulation of age-related macular degeneration-like pathology by complement factor H.

Toomey CB, Kelly U, Saban DR, Bowes Rickman C.

Proc Natl Acad Sci U S A. 2015 Jun 9;112(23):E3040-9. doi: 10.1073/pnas.1424391112. Epub 2015 May 19.


A novel role of complement in retinal degeneration.

Yu M, Zou W, Peachey NS, McIntyre TM, Liu J.

Invest Ophthalmol Vis Sci. 2012 Nov 19;53(12):7684-92. doi: 10.1167/iovs.12-10069.


Cfh genotype interacts with dietary glycemic index to modulate age-related macular degeneration-like features in mice.

Rowan S, Weikel K, Chang ML, Nagel BA, Thinschmidt JS, Carey A, Grant MB, Fliesler SJ, Smith D, Taylor A.

Invest Ophthalmol Vis Sci. 2014 Jan 23;55(1):492-501. doi: 10.1167/iovs.13-12413.


Retinal changes precede visual dysfunction in the complement factor H knockout mouse.

Williams JA, Greenwood J, Moss SE.

PLoS One. 2013 Jul 2;8(7):e68616. doi: 10.1371/journal.pone.0068616. Print 2013.


A targeted inhibitor of the alternative complement pathway reduces angiogenesis in a mouse model of age-related macular degeneration.

Rohrer B, Long Q, Coughlin B, Wilson RB, Huang Y, Qiao F, Tang PH, Kunchithapautham K, Gilkeson GS, Tomlinson S.

Invest Ophthalmol Vis Sci. 2009 Jul;50(7):3056-64. doi: 10.1167/iovs.08-2222. Epub 2009 Mar 5.


C-reactive protein and complement factor H in aged human eyes and eyes with age-related macular degeneration.

Bhutto IA, Baba T, Merges C, Juriasinghani V, McLeod DS, Lutty GA.

Br J Ophthalmol. 2011 Sep;95(9):1323-30. doi: 10.1136/bjo.2010.199216. Epub 2011 Jun 1.


Topical cyclodextrin reduces amyloid beta and inflammation improving retinal function in ageing mice.

Hoh Kam J, Lynch A, Begum R, Cunea A, Jeffery G.

Exp Eye Res. 2015 Jun;135:59-66. doi: 10.1016/j.exer.2015.03.023. Epub 2015 Apr 25.


Aged complement factor H knockout mice kept in a clean barriered environment have reduced retinal pathology.

Hoh Kam J, Morgan JE, Jeffery G.

Exp Eye Res. 2016 Aug;149:116-125. doi: 10.1016/j.exer.2016.07.002. Epub 2016 Jul 7.


Retinal ultrastructure of murine models of dry age-related macular degeneration (AMD).

Ramkumar HL, Zhang J, Chan CC.

Prog Retin Eye Res. 2010 May;29(3):169-90. doi: 10.1016/j.preteyeres.2010.02.002. Epub 2010 Mar 3. Review.


Risk alleles in CFH and ARMS2 are independently associated with systemic complement activation in age-related macular degeneration.

Smailhodzic D, Klaver CC, Klevering BJ, Boon CJ, Groenewoud JM, Kirchhof B, Daha MR, den Hollander AI, Hoyng CB.

Ophthalmology. 2012 Feb;119(2):339-46. doi: 10.1016/j.ophtha.2011.07.056. Epub 2011 Nov 30.


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