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AMP-activated protein kinase: a target for old drugs against diabetes and cancer.

Russo GL, Russo M, Ungaro P.

Biochem Pharmacol. 2013 Aug 1;86(3):339-50. doi: 10.1016/j.bcp.2013.05.023. Epub 2013 Jun 6. Review.


AMP-activated protein kinase in metabolic control and insulin signaling.

Towler MC, Hardie DG.

Circ Res. 2007 Feb 16;100(3):328-41. Review.


[Regulation of energy metabolism by AMPK: a novel therapeutic approach for the treatment of metabolic and cardiovascular diseases].

Foretz M, Taleux N, Guigas B, Horman S, Beauloye C, Andreelli F, Bertrand L, Viollet B.

Med Sci (Paris). 2006 Apr;22(4):381-8. Review. French.


AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer.

Hardie DG.

Biochem Soc Trans. 2011 Jan;39(1):1-13. doi: 10.1042/BST0390001.


AMPK inhibition in health and disease.

Viollet B, Horman S, Leclerc J, Lantier L, Foretz M, Billaud M, Giri S, Andreelli F.

Crit Rev Biochem Mol Biol. 2010 Aug;45(4):276-95. doi: 10.3109/10409238.2010.488215. Review.


AMPK: an emerging drug target for diabetes and the metabolic syndrome.

Zhang BB, Zhou G, Li C.

Cell Metab. 2009 May;9(5):407-16. doi: 10.1016/j.cmet.2009.03.012. Review.


AMPK: a key regulator of energy balance in the single cell and the whole organism.

Hardie DG.

Int J Obes (Lond). 2008 Sep;32 Suppl 4:S7-12. doi: 10.1038/ijo.2008.116. Review.


AMPK is a direct adenylate charge-regulated protein kinase.

Oakhill JS, Steel R, Chen ZP, Scott JW, Ling N, Tam S, Kemp BE.

Science. 2011 Jun 17;332(6036):1433-5. doi: 10.1126/science.1200094.


[Metformin and AMPK: an old drug and a new enzyme in the context of metabolic syndrome].

Santomauro Júnior AC, Ugolini MR, Santomauro AT, Souto RP.

Arq Bras Endocrinol Metabol. 2008 Feb;52(1):120-5. Review. Portuguese.


β-Subunit myristoylation is the gatekeeper for initiating metabolic stress sensing by AMP-activated protein kinase (AMPK).

Oakhill JS, Chen ZP, Scott JW, Steel R, Castelli LA, Ling N, Macaulay SL, Kemp BE.

Proc Natl Acad Sci U S A. 2010 Nov 9;107(45):19237-41. doi: 10.1073/pnas.1009705107. Epub 2010 Oct 25.


[AMP-activated protein kinase (AMPK) as therapeutic target].

Sarnowska E, Balcerak A, Olszyna-Serementa M, Kotlarek D, Sarnowski TJ, Siedlecki JA.

Postepy Hig Med Dosw (Online). 2013 Aug 5;67:750-60. Review. Polish.


Targeting AMPK: From Ancient Drugs to New Small-Molecule Activators.

Guigas B, Viollet B.

EXS. 2016;107:327-350. Review.


AMP-activated protein kinase: a target for drugs both ancient and modern.

Hardie DG, Ross FA, Hawley SA.

Chem Biol. 2012 Oct 26;19(10):1222-36. doi: 10.1016/j.chembiol.2012.08.019. Review.


Metformin and cancer.

Vallianou NG, Evangelopoulos A, Kazazis C.

Rev Diabet Stud. 2013 Winter;10(4):228-35. doi: 10.1900/RDS.2013.10.228. Epub 2014 Feb 10. Review.


Targeting AMP-activated protein kinase as a novel therapeutic approach for the treatment of metabolic disorders.

Viollet B, Mounier R, Leclerc J, Yazigi A, Foretz M, Andreelli F.

Diabetes Metab. 2007 Dec;33(6):395-402. Epub 2007 Nov 7. Review.


Small molecule antagonizes autoinhibition and activates AMP-activated protein kinase in cells.

Pang T, Zhang ZS, Gu M, Qiu BY, Yu LF, Cao PR, Shao W, Su MB, Li JY, Nan FJ, Li J.

J Biol Chem. 2008 Jun 6;283(23):16051-60. doi: 10.1074/jbc.M710114200. Epub 2008 Mar 5.


Role of AMP-activated protein kinase in cancer therapy.

Rehman G, Shehzad A, Khan AL, Hamayun M.

Arch Pharm (Weinheim). 2014 Jul;347(7):457-68. doi: 10.1002/ardp.201300402. Epub 2014 Mar 28. Review.


Activation of the AMP-activated protein kinase by the anti-diabetic drug metformin in vivo. Role of mitochondrial reactive nitrogen species.

Zou MH, Kirkpatrick SS, Davis BJ, Nelson JS, Wiles WG 4th, Schlattner U, Neumann D, Brownlee M, Freeman MB, Goldman MH.

J Biol Chem. 2004 Oct 15;279(42):43940-51. Epub 2004 Jul 19.


Metformin increases AMP-activated protein kinase activity in skeletal muscle of subjects with type 2 diabetes.

Musi N, Hirshman MF, Nygren J, Svanfeldt M, Bavenholm P, Rooyackers O, Zhou G, Williamson JM, Ljunqvist O, Efendic S, Moller DE, Thorell A, Goodyear LJ.

Diabetes. 2002 Jul;51(7):2074-81.


Role of AMP-activated protein kinase in mechanism of metformin action.

Zhou G, Myers R, Li Y, Chen Y, Shen X, Fenyk-Melody J, Wu M, Ventre J, Doebber T, Fujii N, Musi N, Hirshman MF, Goodyear LJ, Moller DE.

J Clin Invest. 2001 Oct;108(8):1167-74.

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