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Differential effects on ARF stability by normal versus oncogenic levels of c-Myc expression.

Chen D, Kon N, Zhong J, Zhang P, Yu L, Gu W.

Mol Cell. 2013 Jul 11;51(1):46-56. doi: 10.1016/j.molcel.2013.05.006. Epub 2013 Jun 6.


The ARF tumor suppressor: keeping Myc on a leash.

Gregory MA, Qi Y, Hann SR.

Cell Cycle. 2005 Feb;4(2):249-52. Epub 2005 Feb 21.


Transcription-independent ARF regulation in oncogenic stress-mediated p53 responses.

Chen D, Shan J, Zhu WG, Qin J, Gu W.

Nature. 2010 Mar 25;464(7288):624-7. doi: 10.1038/nature08820. Epub 2010 Mar 7.


p19ARF directly and differentially controls the functions of c-Myc independently of p53.

Qi Y, Gregory MA, Li Z, Brousal JP, West K, Hann SR.

Nature. 2004 Oct 7;431(7009):712-7. Epub 2004 Sep 8.


Reactivating the ARF-p53 axis in AML cells by targeting ULF.

Chen D, Yoon JB, Gu W.

Cell Cycle. 2010 Aug 1;9(15):2946-51. doi: 10.4161/cc.9.15.12355. Epub 2010 Aug 11.


NMI mediates transcription-independent ARF regulation in response to cellular stresses.

Li Z, Hou J, Sun L, Wen T, Wang L, Zhao X, Xie Q, Zhang SQ.

Mol Biol Cell. 2012 Dec;23(23):4635-46. doi: 10.1091/mbc.E12-04-0304. Epub 2012 Oct 3.


Myc-ARF (alternate reading frame) interaction inhibits the functions of Myc.

Datta A, Nag A, Pan W, Hay N, Gartel AL, Colamonici O, Mori Y, Raychaudhuri P.

J Biol Chem. 2004 Aug 27;279(35):36698-707. Epub 2004 Jun 15.


ARF-BP1/Mule is a critical mediator of the ARF tumor suppressor.

Chen D, Kon N, Li M, Zhang W, Qin J, Gu W.

Cell. 2005 Jul 1;121(7):1071-83.


Characterization of ARF-BP1/HUWE1 interactions with CTCF, MYC, ARF and p53 in MYC-driven B cell neoplasms.

Qi CF, Kim YS, Xiang S, Abdullaev Z, Torrey TA, Janz S, Kovalchuk AL, Sun J, Chen D, Cho WC, Gu W, Morse HC 3rd.

Int J Mol Sci. 2012;13(5):6204-19. doi: 10.3390/ijms13056204. Epub 2012 May 21.


Bcl-2 is an apoptotic target suppressed by both c-Myc and E2F-1.

Eischen CM, Packham G, Nip J, Fee BE, Hiebert SW, Zambetti GP, Cleveland JL.

Oncogene. 2001 Oct 25;20(48):6983-93.


Regulation of Myc function by ARF: checkpoint for Myc-induced oncogenesis.

Sarkar D, Fisher PB.

Cancer Biol Ther. 2006 Jun;5(6):693-5. Epub 2006 Jun 25.


The Myc-nucleophosmin-ARF network: a complex web unveiled.

Li Z, Hann SR.

Cell Cycle. 2009 Sep 1;8(17):2703-7. Epub 2009 Sep 2. Review.


Nucleostemin stabilizes ARF by inhibiting the ubiquitin ligase ULF.

Lo D, Zhang Y, Dai MS, Sun XX, Zeng SX, Lu H.

Oncogene. 2015 Mar 26;34(13):1688-97. doi: 10.1038/onc.2014.103. Epub 2014 Apr 28.


Arf tumor suppressor disrupts the oncogenic positive feedback loop including c-Myc and DDX5.

Tago K, Funakoshi-Tago M, Itoh H, Furukawa Y, Kikuchi J, Kato T, Suzuki K, Yanagisawa K.

Oncogene. 2015 Jan 15;34(3):314-22. doi: 10.1038/onc.2013.561. Epub 2014 Jan 27.


E2F activity is essential for survival of Myc-overexpressing human cancer cells.

Santoni-Rugiu E, Duro D, Farkas T, Mathiasen IS, Jäättelä M, Bartek J, Lukas J.

Oncogene. 2002 Sep 19;21(42):6498-509.


ARF differentially modulates apoptosis induced by E2F1 and Myc.

Russell JL, Powers JT, Rounbehler RJ, Rogers PM, Conti CJ, Johnson DG.

Mol Cell Biol. 2002 Mar;22(5):1360-8.


Controlling ARF stability: new players added to the team.

Tavana O, Chen D, Gu W.

Cell Cycle. 2014;13(4):497-8. doi: 10.4161/cc.27786. Epub 2014 Jan 13. No abstract available.


Egr1 mediates p53-independent c-Myc-induced apoptosis via a noncanonical ARF-dependent transcriptional mechanism.

Boone DN, Qi Y, Li Z, Hann SR.

Proc Natl Acad Sci U S A. 2011 Jan 11;108(2):632-7. doi: 10.1073/pnas.1008848108. Epub 2010 Dec 27.


Gliomagenesis arising from Pten- and Ink4a/Arf-deficient neural progenitor cells is mediated by the p53-Fbxw7/Cdc4 pathway, which controls c-Myc.

Kim HS, Woolard K, Lai C, Bauer PO, Maric D, Song H, Li A, Kotliarova S, Zhang W, Fine HA.

Cancer Res. 2012 Nov 15;72(22):6065-75. doi: 10.1158/0008-5472.CAN-12-2594. Epub 2012 Sep 17.


Bax loss impairs Myc-induced apoptosis and circumvents the selection of p53 mutations during Myc-mediated lymphomagenesis.

Eischen CM, Roussel MF, Korsmeyer SJ, Cleveland JL.

Mol Cell Biol. 2001 Nov;21(22):7653-62.

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