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The XPA-binding domain of ERCC1 is required for nucleotide excision repair but not other DNA repair pathways.

Orelli B, McClendon TB, Tsodikov OV, Ellenberger T, Niedernhofer LJ, Schärer OD.

J Biol Chem. 2010 Feb 5;285(6):3705-12. doi: 10.1074/jbc.M109.067538. Epub 2009 Nov 23.


Structural basis for the recruitment of ERCC1-XPF to nucleotide excision repair complexes by XPA.

Tsodikov OV, Ivanov D, Orelli B, Staresincic L, Shoshani I, Oberman R, Schärer OD, Wagner G, Ellenberger T.

EMBO J. 2007 Nov 14;26(22):4768-76. Epub 2007 Oct 18.


DNA repair gets physical: mapping an XPA-binding site on ERCC1.

Croteau DL, Peng Y, Van Houten B.

DNA Repair (Amst). 2008 May 3;7(5):819-26. doi: 10.1016/j.dnarep.2008.01.018. Epub 2008 Mar 14. Review.


Analysis of the XPA and ssDNA-binding surfaces on the central domain of human ERCC1 reveals evidence for subfunctionalization.

Tripsianes K, Folkers GE, Zheng C, Das D, Grinstead JS, Kaptein R, Boelens R.

Nucleic Acids Res. 2007;35(17):5789-98. Epub 2007 Aug 24.


New design of nucleotide excision repair (NER) inhibitors for combination cancer therapy.

Gentile F, Tuszynski JA, Barakat KH.

J Mol Graph Model. 2016 Apr;65:71-82. doi: 10.1016/j.jmgm.2016.02.010. Epub 2016 Feb 26.


The role of conformational selection in the molecular recognition of the wild type and mutants XPA67-80 peptides by ERCC1.

Fadda E.

Proteins. 2015 Jul;83(7):1341-51. doi: 10.1002/prot.24825. Epub 2015 May 29.


Characterization of an inhibitory dynamic pharmacophore for the ERCC1-XPA interaction using a combined molecular dynamics and virtual screening approach.

Barakat KH, Torin Huzil J, Luchko T, Jordheim L, Dumontet C, Tuszynski J.

J Mol Graph Model. 2009 Sep;28(2):113-30. doi: 10.1016/j.jmgm.2009.04.009. Epub 2009 May 4.


Mutations in XPA that prevent association with ERCC1 are defective in nucleotide excision repair.

Li L, Peterson CA, Lu X, Legerski RJ.

Mol Cell Biol. 1995 Apr;15(4):1993-8.


Sequential binding of DNA repair proteins RPA and ERCC1 to XPA in vitro.

Saijo M, Kuraoka I, Masutani C, Hanaoka F, Tanaka K.

Nucleic Acids Res. 1996 Dec 1;24(23):4719-24.


Functional and physical interactions between ERCC1 and MSH2 complexes for resistance to cis-diamminedichloroplatinum(II) in mammalian cells.

Lan L, Hayashi T, Rabeya RM, Nakajima S, Kanno Si, Takao M, Matsunaga T, Yoshino M, Ichikawa M, Riele Ht, Tsuchiya S, Tanaka K, Yasui A.

DNA Repair (Amst). 2004 Feb 3;3(2):135-43.


Virtual screening and biological evaluation of inhibitors targeting the XPA-ERCC1 interaction.

Barakat KH, Jordheim LP, Perez-Pineiro R, Wishart D, Dumontet C, Tuszynski JA.

PLoS One. 2012;7(12):e51329. doi: 10.1371/journal.pone.0051329. Epub 2012 Dec 14.


Multiple DNA binding domains mediate the function of the ERCC1-XPF protein in nucleotide excision repair.

Su Y, Orelli B, Madireddy A, Niedernhofer LJ, Schärer OD.

J Biol Chem. 2012 Jun 22;287(26):21846-55. doi: 10.1074/jbc.M111.337899. Epub 2012 Apr 30.


Inhibition of nucleotide excision repair by anti-XPA monoclonal antibodies which interfere with binding to RPA, ERCC1, and TFIIH.

Saijo M, Matsuda T, Kuraoka I, Tanaka K.

Biochem Biophys Res Commun. 2004 Sep 3;321(4):815-22.


Nucleotide excision repair is associated with the replisome and its efficiency depends on a direct interaction between XPA and PCNA.

Gilljam KM, Müller R, Liabakk NB, Otterlei M.

PLoS One. 2012;7(11):e49199. doi: 10.1371/journal.pone.0049199. Epub 2012 Nov 13.


Enhancement of damage-specific DNA binding of XPA by interaction with the ERCC1 DNA repair protein.

Nagai A, Saijo M, Kuraoka I, Matsuda T, Kodo N, Nakatsu Y, Mimaki T, Mino M, Biggerstaff M, Wood RD, et al.

Biochem Biophys Res Commun. 1995 Jun 26;211(3):960-6.


A new structural insight into XPA-DNA interactions.

Hilton B, Shkriabai N, Musich PR, Kvaratskhelia M, Shell S, Zou Y.

Biosci Rep. 2014 Dec 12;34(6):e00162. doi: 10.1042/BSR20140158.


Three-dimensional structural views of damaged-DNA recognition: T4 endonuclease V, E. coli Vsr protein, and human nucleotide excision repair factor XPA.

Morikawa K, Shirakawa M.

Mutat Res. 2000 Aug 30;460(3-4):257-75. Review. Erratum in: Mutat Res 2001 Apr 4;485(3):267-8.


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