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Items: 1 to 20 of 87

1.
2.

Mitochondrial mutations and ageing: can mitochondrial deletion mutants accumulate via a size based replication advantage?

Kowald A, Dawson M, Kirkwood TB.

J Theor Biol. 2014 Jan 7;340:111-8. doi: 10.1016/j.jtbi.2013.09.009. Epub 2013 Sep 17.

PMID:
24055401
3.

Transcription could be the key to the selection advantage of mitochondrial deletion mutants in aging.

Kowald A, Kirkwood TB.

Proc Natl Acad Sci U S A. 2014 Feb 25;111(8):2972-7. doi: 10.1073/pnas.1314970111. Epub 2014 Feb 3.

4.

On the relevance of mitochondrial fusions for the accumulation of mitochondrial deletion mutants: a modelling study.

Kowald A, Jendrach M, Pohl S, Bereiter-Hahn J, Hammerstein P.

Aging Cell. 2005 Oct;4(5):273-83.

5.

Mathematical modeling of the role of mitochondrial fusion and fission in mitochondrial DNA maintenance.

Tam ZY, Gruber J, Halliwell B, Gunawan R.

PLoS One. 2013 Oct 11;8(10):e76230. doi: 10.1371/journal.pone.0076230. eCollection 2013.

6.
7.

Random intracellular drift explains the clonal expansion of mitochondrial DNA mutations with age.

Elson JL, Samuels DC, Turnbull DM, Chinnery PF.

Am J Hum Genet. 2001 Mar;68(3):802-6. Epub 2001 Feb 6.

8.

Frequent intracellular clonal expansions of somatic mtDNA mutations: significance and mechanisms.

Coller HA, Bodyak ND, Khrapko K.

Ann N Y Acad Sci. 2002 Apr;959:434-47.

PMID:
11976216
9.

Is selection required for the accumulation of somatic mitochondrial DNA mutations in post-mitotic cells?

Durham SE, Samuels DC, Chinnery PF.

Neuromuscul Disord. 2006 Jun;16(6):381-6. Epub 2006 May 8.

PMID:
16684599
10.

Mitochondrial DNA mutation and the ageing process: bioenergy and pharmacological intervention.

Linnane AW, Zhang C, Baumer A, Nagley P.

Mutat Res. 1992 Sep;275(3-6):195-208. Review.

PMID:
1383761
11.

The distribution of mitochondrial DNA heteroplasmy due to random genetic drift.

Wonnapinij P, Chinnery PF, Samuels DC.

Am J Hum Genet. 2008 Nov;83(5):582-93. doi: 10.1016/j.ajhg.2008.10.007. Epub 2008 Oct 30.

12.

Context-Dependent Role of Mitochondrial Fusion-Fission in Clonal Expansion of mtDNA Mutations.

Tam ZY, Gruber J, Halliwell B, Gunawan R.

PLoS Comput Biol. 2015 May 21;11(5):e1004183. doi: 10.1371/journal.pcbi.1004183. eCollection 2015 May.

13.

Estimation of the mtDNA mutation rate in aging mice by proteome analysis and mathematical modeling.

Mao L, Zabel C, Wacker MA, Nebrich G, Sagi D, Schrade P, Bachmann S, Kowald A, Klose J.

Exp Gerontol. 2006 Jan;41(1):11-24. Epub 2005 Nov 22.

PMID:
16307857
14.

Mitochondrial DNA mutations as a fundamental mechanism in physiological declines associated with aging.

Pak JW, Herbst A, Bua E, Gokey N, McKenzie D, Aiken JM.

Aging Cell. 2003 Feb;2(1):1-7.

PMID:
12882328
15.

Oxidative stress response elicited by mitochondrial dysfunction: implication in the pathophysiology of aging.

Wang CH, Wu SB, Wu YT, Wei YH.

Exp Biol Med (Maywood). 2013 May;238(5):450-60. doi: 10.1177/1535370213493069. Review.

PMID:
23856898
16.

Mitochondria: Biogenesis and mitophagy balance in segregation and clonal expansion of mitochondrial DNA mutations.

Carelli V, Maresca A, Caporali L, Trifunov S, Zanna C, Rugolo M.

Int J Biochem Cell Biol. 2015 Jun;63:21-4. doi: 10.1016/j.biocel.2015.01.023. Epub 2015 Feb 7. Review.

PMID:
25666555
17.

Human aging is associated with stochastic somatic mutations of mitochondrial DNA.

Kadenbach B, Münscher C, Frank V, Müller-Höcker J, Napiwotzki J.

Mutat Res. 1995 Oct;338(1-6):161-72. Review.

PMID:
7565871
18.

mtLOH (mitochondrial loss of heteroplasmy), aging, and 'surrogate self'.

Nekhaeva E, Kraytsberg Y, Khrapko K.

Mech Ageing Dev. 2002 Apr 30;123(8):891-8. Review.

PMID:
12044937
19.

Direct repeats in mitochondrial DNA and mammalian lifespan.

Khaidakov M, Siegel ER, Shmookler Reis RJ.

Mech Ageing Dev. 2006 Oct;127(10):808-12. Epub 2006 Sep 7.

PMID:
16956646
20.

Mitochondria and aging: innocent bystanders or guilty parties?

Tońska K, Sołyga A, Bartnik E.

J Appl Genet. 2009;50(1):55-62. doi: 10.1007/BF03195653.

PMID:
19193984

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