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Items: 1 to 20 of 125

1.

Epithelial-specific deletion of 11β-HSD2 hinders Apcmin/+ mouse tumorigenesis.

Jiang L, Yang S, Yin H, Fan X, Wang S, Yao B, Pozzi A, Chen X, Harris RC, Zhang MZ.

Mol Cancer Res. 2013 Sep;11(9):1040-50. doi: 10.1158/1541-7786.MCR-13-0084-T. Epub 2013 Jun 5.

2.

Inhibition of 11beta-hydroxysteroid dehydrogenase type II selectively blocks the tumor COX-2 pathway and suppresses colon carcinogenesis in mice and humans.

Zhang MZ, Xu J, Yao B, Yin H, Cai Q, Shrubsole MJ, Chen X, Kon V, Zheng W, Pozzi A, Harris RC.

J Clin Invest. 2009 Apr;119(4):876-85. doi: 10.1172/JCI37398. Epub 2009 Mar 23.

3.

Inhibition of 11β-Hydroxysteroid Dehydrogenase Type II Suppresses Lung Carcinogenesis by Blocking Tumor COX-2 Expression as Well as the ERK and mTOR Signaling Pathways.

Chang J, Xue M, Yang S, Yao B, Zhang B, Chen X, Pozzi A, Zhang MZ.

PLoS One. 2015 May 26;10(5):e0127030. doi: 10.1371/journal.pone.0127030. eCollection 2015.

4.

Regulation of stromal cell cyclooxygenase-2 in the ApcMin/+ mouse model of intestinal tumorigenesis.

Hull MA, Faluyi OO, Ko CW, Holwell S, Scott DJ, Cuthbert RJ, Poulsom R, Goodlad R, Bonifer C, Markham AF, Coletta PL.

Carcinogenesis. 2006 Mar;27(3):382-91. Epub 2005 Oct 11.

PMID:
16219637
5.

11{beta}-Hydroxysteroid dehydrogenase 2 in rat leydig cells: its role in blunting glucocorticoid action at physiological levels of substrate.

Ge RS, Dong Q, Niu EM, Sottas CM, Hardy DO, Catterall JF, Latif SA, Morris DJ, Hardy MP.

Endocrinology. 2005 Jun;146(6):2657-64. Epub 2005 Mar 10.

PMID:
15761036
6.

The ERK1/2 signaling pathway regulates 11beta-hydroxysteroid dehydrogenase type 2 expression in human trophoblast cells through a transcriptional mechanism.

Guan H, Sun K, Yang K.

Biol Reprod. 2013 Oct 17;89(4):92. doi: 10.1095/biolreprod.113.110924. Print 2013 Oct.

PMID:
23966319
7.

Stromal Indian hedgehog signaling is required for intestinal adenoma formation in mice.

Büller NV, Rosekrans SL, Metcalfe C, Heijmans J, van Dop WA, Fessler E, Jansen M, Ahn C, Vermeulen JL, Westendorp BF, Robanus-Maandag EC, Offerhaus GJ, Medema JP, D'Haens GR, Wildenberg ME, de Sauvage FJ, Muncan V, van den Brink GR.

Gastroenterology. 2015 Jan;148(1):170-180.e6. doi: 10.1053/j.gastro.2014.10.006. Epub 2014 Oct 13.

PMID:
25307863
8.
9.

Characterization of activity and binding mode of glycyrrhetinic acid derivatives inhibiting 11β-hydroxysteroid dehydrogenase type 2.

Kratschmar DV, Vuorinen A, Da Cunha T, Wolber G, Classen-Houben D, Doblhoff O, Schuster D, Odermatt A.

J Steroid Biochem Mol Biol. 2011 May;125(1-2):129-42. doi: 10.1016/j.jsbmb.2010.12.019. Epub 2011 Jan 12.

PMID:
21236343
10.

KLF4 Suppresses Tumor Formation in Genetic and Pharmacological Mouse Models of Colonic Tumorigenesis.

Ghaleb AM, Elkarim EA, Bialkowska AB, Yang VW.

Mol Cancer Res. 2016 Apr;14(4):385-96. doi: 10.1158/1541-7786.MCR-15-0410. Epub 2016 Feb 2.

11.

Apc deficiency is associated with increased Egfr activity in the intestinal enterocytes and adenomas of C57BL/6J-Min/+ mice.

Moran AE, Hunt DH, Javid SH, Redston M, Carothers AM, Bertagnolli MM.

J Biol Chem. 2004 Oct 8;279(41):43261-72. Epub 2004 Aug 4.

12.

Macrophage migration inhibitory factor promotes intestinal tumorigenesis.

Wilson JM, Coletta PL, Cuthbert RJ, Scott N, MacLennan K, Hawcroft G, Leng L, Lubetsky JB, Jin KK, Lolis E, Medina F, Brieva JA, Poulsom R, Markham AF, Bucala R, Hull MA.

Gastroenterology. 2005 Nov;129(5):1485-503.

PMID:
16285950
13.

Aldosterone enhances 11beta-hydroxysteroid dehydrogenase type 2 expression in colonic epithelial cells in vivo.

Fukushima K, Funayama Y, Yonezawa H, Takahashi K, Haneda S, Suzuki T, Sasano H, Naito H, Shibata C, Krozowski ZS, Sasaki I.

Scand J Gastroenterol. 2005 Jul;40(7):850-7.

PMID:
16109662
14.

Deletion of the AU-rich RNA binding protein Apobec-1 reduces intestinal tumor burden in Apc(min) mice.

Blanc V, Henderson JO, Newberry RD, Xie Y, Cho SJ, Newberry EP, Kennedy S, Rubin DC, Wang HL, Luo J, Davidson NO.

Cancer Res. 2007 Sep 15;67(18):8565-73.

15.

Loss of free fatty acid receptor 2 enhances colonic adenoma development and reduces the chemopreventive effects of black raspberries in ApcMin/+ mice.

Pan P, W Skaer C, Wang HT, Oshima K, Huang YW, Yu J, Zhang J, M Yearsley M, A Agle K, R Drobyski W, Chen X, Wang LS.

Carcinogenesis. 2017 Jan;38(1):86-93. doi: 10.1093/carcin/bgw122. Epub 2016 Nov 19.

PMID:
27866157
16.

Down-regulation of 11β-hydroxysteroid dehydrogenase type 2 by bortezomib sensitizes Jurkat leukemia T cells against glucocorticoid-induced apoptosis.

Tao Y, Gao L, Wu X, Wang H, Yang G, Zhan F, Shi J.

PLoS One. 2013 Jun 24;8(6):e67067. doi: 10.1371/journal.pone.0067067. Print 2013.

17.

CKIα ablation highlights a critical role for p53 in invasiveness control.

Elyada E, Pribluda A, Goldstein RE, Morgenstern Y, Brachya G, Cojocaru G, Snir-Alkalay I, Burstain I, Haffner-Krausz R, Jung S, Wiener Z, Alitalo K, Oren M, Pikarsky E, Ben-Neriah Y.

Nature. 2011 Feb 17;470(7334):409-13. doi: 10.1038/nature09673.

PMID:
21331045
18.

Mouse model of colonic adenoma-carcinoma progression based on somatic Apc inactivation.

Hinoi T, Akyol A, Theisen BK, Ferguson DO, Greenson JK, Williams BO, Cho KR, Fearon ER.

Cancer Res. 2007 Oct 15;67(20):9721-30.

19.

Expression of 11β-hydroxysteroid dehydrogenase 1 and 2 in patients with chronic rhinosinusitis and their possible contribution to local glucocorticoid activation in sinus mucosa.

Jun YJ, Park SJ, Kim TH, Lee SH, Lee KJ, Hwang SM, Lee SH.

J Allergy Clin Immunol. 2014 Oct;134(4):926-934.e6. doi: 10.1016/j.jaci.2014.03.033. Epub 2014 May 5.

PMID:
24810847

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