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Hypoxia-induced invadopodia formation: a role for β-PIX.

Md Hashim NF, Nicholas NS, Dart AE, Kiriakidis S, Paleolog E, Wells CM.

Open Biol. 2013 Jun 5;3(6):120159. doi: 10.1098/rsob.120159.


Intermediary metabolite precursor dimethyl-2-ketoglutarate stabilizes hypoxia-inducible factor-1α by inhibiting prolyl-4-hydroxylase PHD2.

Hou P, Kuo CY, Cheng CT, Liou JP, Ann DK, Chen Q.

PLoS One. 2014 Nov 24;9(11):e113865. doi: 10.1371/journal.pone.0113865.


Increased activation of the hypoxia-inducible factor pathway in varicose veins.

Lim CS, Kiriakidis S, Paleolog EM, Davies AH.

J Vasc Surg. 2012 May;55(5):1427-39. doi: 10.1016/j.jvs.2011.10.111.


Signal transducer and activator of transcription 3 is required for hypoxia-inducible factor-1alpha RNA expression in both tumor cells and tumor-associated myeloid cells.

Niu G, Briggs J, Deng J, Ma Y, Lee H, Kortylewski M, Kujawski M, Kay H, Cress WD, Jove R, Yu H.

Mol Cancer Res. 2008 Jul;6(7):1099-105. doi: 10.1158/1541-7786.MCR-07-2177.


Rhapontigenin inhibited hypoxia inducible factor 1 alpha accumulation and angiogenesis in hypoxic PC-3 prostate cancer cells.

Jung DB, Lee HJ, Jeong SJ, Lee HJ, Lee EO, Kim YC, Ahn KS, Chen CY, Kim SH.

Biol Pharm Bull. 2011;34(6):850-5.


Concordant regulation of gene expression by hypoxia and 2-oxoglutarate-dependent dioxygenase inhibition: the role of HIF-1alpha, HIF-2alpha, and other pathways.

Elvidge GP, Glenny L, Appelhoff RJ, Ratcliffe PJ, Ragoussis J, Gleadle JM.

J Biol Chem. 2006 Jun 2;281(22):15215-26.


Notch1 is required for hypoxia-induced proliferation, invasion and chemoresistance of T-cell acute lymphoblastic leukemia cells.

Zou J, Li P, Lu F, Liu N, Dai J, Ye J, Qu X, Sun X, Ma D, Park J, Ji C.

J Hematol Oncol. 2013 Jan 5;6:3. doi: 10.1186/1756-8722-6-3.


A hypoxia-induced decrease of either MICA/B or Hsp70 on the membrane of tumor cells mediates immune escape from NK cells.

Schilling D, Tetzlaff F, Konrad S, Li W, Multhoff G.

Cell Stress Chaperones. 2015 Jan;20(1):139-47. doi: 10.1007/s12192-014-0532-5.


ERRα augments HIF-1 signalling by directly interacting with HIF-1α in normoxic and hypoxic prostate cancer cells.

Zou C, Yu S, Xu Z, Wu D, Ng CF, Yao X, Yew DT, Vanacker JM, Chan FL.

J Pathol. 2014 May;233(1):61-73. doi: 10.1002/path.4329.


Hydrogen sulfide inhibits the translational expression of hypoxia-inducible factor-1α.

Wu B, Teng H, Yang G, Wu L, Wang R.

Br J Pharmacol. 2012 Dec;167(7):1492-505. doi: 10.1111/j.1476-5381.2012.02113.x.


HIF-1α/GPER signaling mediates the expression of VEGF induced by hypoxia in breast cancer associated fibroblasts (CAFs).

De Francesco EM, Lappano R, Santolla MF, Marsico S, Caruso A, Maggiolini M.

Breast Cancer Res. 2013;15(4):R64.


Identification of thioredoxin-interacting protein 1 as a hypoxia-inducible factor 1alpha-induced gene in pancreatic cancer.

Baker AF, Koh MY, Williams RR, James B, Wang H, Tate WR, Gallegos A, Von Hoff DD, Han H, Powis G.

Pancreas. 2008 Mar;36(2):178-86. doi: 10.1097/MPA.0b013e31815929fe.


Hypoxia-induced increases in A549/CDDP cell drug resistance are reversed by RNA interference of HIF-1α expression.

Min L, Chen Q, He S, Liu S, Ma Y.

Mol Med Rep. 2012 Jan;5(1):228-32. doi: 10.3892/mmr.2011.604.


Suppression of hypoxia-inducible factor 1α (HIF-1α) by tirapazamine is dependent on eIF2α phosphorylation rather than the mTORC1/4E-BP1 pathway.

Zhang J, Cao J, Weng Q, Wu R, Yan Y, Jing H, Zhu H, He Q, Yang B.

PLoS One. 2010 Nov 9;5(11):e13910. doi: 10.1371/journal.pone.0013910.


Autophagy in cancer associated fibroblasts promotes tumor cell survival: Role of hypoxia, HIF1 induction and NFκB activation in the tumor stromal microenvironment.

Martinez-Outschoorn UE, Trimmer C, Lin Z, Whitaker-Menezes D, Chiavarina B, Zhou J, Wang C, Pavlides S, Martinez-Cantarin MP, Capozza F, Witkiewicz AK, Flomenberg N, Howell A, Pestell RG, Caro J, Lisanti MP, Sotgia F.

Cell Cycle. 2010 Sep 1;9(17):3515-33.


Cobalt stimulates HIF-1-dependent but inhibits HIF-2-dependent gene expression in liver cancer cells.

Befani C, Mylonis I, Gkotinakou IM, Georgoulias P, Hu CJ, Simos G, Liakos P.

Int J Biochem Cell Biol. 2013 Nov;45(11):2359-68. doi: 10.1016/j.biocel.2013.07.025.


PITX1, a specificity determinant in the HIF-1α-mediated transcriptional response to hypoxia.

Mudie S, Bandarra D, Batie M, Biddlestone J, Moniz S, Ortmann B, Shmakova A, Rocha S.

Cell Cycle. 2014;13(24):3878-91. doi: 10.4161/15384101.2014.972889.

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