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Role of EZH2 in the growth of prostate cancer stem cells isolated from LNCaP cells.

Li K, Liu C, Zhou B, Bi L, Huang H, Lin T, Xu K.

Int J Mol Sci. 2013 Jun 5;14(6):11981-93. doi: 10.3390/ijms140611981.


MicroRNA-7 inhibits the stemness of prostate cancer stem-like cells and tumorigenesis by repressing KLF4/PI3K/Akt/p21 pathway.

Chang YL, Zhou PJ, Wei L, Li W, Ji Z, Fang YX, Gao WQ.

Oncotarget. 2015 Sep 15;6(27):24017-31.


Polycomb protein EZH2 suppresses apoptosis by silencing the proapoptotic miR-31.

Zhang Q, Padi SK, Tindall DJ, Guo B.

Cell Death Dis. 2014 Oct 23;5:e1486. doi: 10.1038/cddis.2014.454.


TR4 Nuclear Receptor Alters the Prostate Cancer CD133+ Stem/Progenitor Cell Invasion via Modulating the EZH2-Related Metastasis Gene Expression.

Zhu J, Yang DR, Sun Y, Qiu X, Chang HC, Li G, Shan Y, Chang C.

Mol Cancer Ther. 2015 Jun;14(6):1445-53. doi: 10.1158/1535-7163.MCT-14-0971. Epub 2015 Apr 1.


Expression analysis of putative stem cell markers in human benign and malignant prostate.

Ugolkov AV, Eisengart LJ, Luan C, Yang XJ.

Prostate. 2011 Jan 1;71(1):18-25. doi: 10.1002/pros.21217.


MiR-214 targets β-catenin pathway to suppress invasion, stem-like traits and recurrence of human hepatocellular carcinoma.

Xia H, Ooi LL, Hui KM.

PLoS One. 2012;7(9):e44206. doi: 10.1371/journal.pone.0044206. Epub 2012 Sep 4. Erratum in: PLoS One. 2012;7(9). doi:10.1371/annotation/1be2a62e-45a1-4c13-9a8d-f265005a21e0.


Inhibition of enhancer of zeste homolog 2 (EZH2) expression is associated with decreased tumor cell proliferation, migration, and invasion in endometrial cancer cell lines.

Eskander RN, Ji T, Huynh B, Wardeh R, Randall LM, Hoang B.

Int J Gynecol Cancer. 2013 Jul;23(6):997-1005. doi: 10.1097/IGC.0b013e318296a265.


MiR-138 inhibits tumor growth through repression of EZH2 in non-small cell lung cancer.

Zhang H, Zhang H, Zhao M, Lv Z, Zhang X, Qin X, Wang H, Wang S, Su J, Lv X, Liu H, Du W, Zhou W, Chen X, Fei K.

Cell Physiol Biochem. 2013;31(1):56-65. doi: 10.1159/000343349. Epub 2013 Jan 15.


Honokiol inhibits bladder tumor growth by suppressing EZH2/miR-143 axis.

Zhang Q, Zhao W, Ye C, Zhuang J, Chang C, Li Y, Huang X, Shen L, Li Y, Cui Y, Song J, Shen B, Eliaz I, Huang R, Ying H, Guo H, Yan J.

Oncotarget. 2015 Nov 10;6(35):37335-48. doi: 10.18632/oncotarget.6135.


MiR-26a and miR-138 block the G1/S transition by targeting the cell cycle regulating network in prostate cancer cells.

Erdmann K, Kaulke K, Rieger C, Salomo K, Wirth MP, Fuessel S.

J Cancer Res Clin Oncol. 2016 Nov;142(11):2249-61. doi: 10.1007/s00432-016-2222-4. Epub 2016 Aug 25.


MicroRNA-101 negatively regulates Ezh2 and its expression is modulated by androgen receptor and HIF-1alpha/HIF-1beta.

Cao P, Deng Z, Wan M, Huang W, Cramer SD, Xu J, Lei M, Sui G.

Mol Cancer. 2010 May 17;9:108. doi: 10.1186/1476-4598-9-108.


A double-negative feedback loop between EZH2 and miR-26a regulates tumor cell growth in hepatocellular carcinoma.

Zhuang C, Wang P, Huang D, Xu L, Wang X, Wang L, Hu L.

Int J Oncol. 2016 Mar;48(3):1195-204. doi: 10.3892/ijo.2016.3336. Epub 2016 Jan 13.


MicroRNA-101 exerts tumor-suppressive functions in non-small cell lung cancer through directly targeting enhancer of zeste homolog 2.

Zhang JG, Guo JF, Liu DL, Liu Q, Wang JJ.

J Thorac Oncol. 2011 Apr;6(4):671-8. doi: 10.1097/JTO.0b013e318208eb35.


 Effect of siRNA targeting EZH2 on cell viability and apoptosis of bladder cancer T24 cells.

Wang HF, Yang H, Hu LB, Lei YH, Qin Y, Li J, Bi CW, Wang JS, Huo Q.

Genet Mol Res. 2014 Nov 27;13(4):9939-50. doi: 10.4238/2014.November.27.23.


EZH2 promotes tumor progression by increasing VEGF expression in clear cell renal cell carcinoma.

Xu ZQ, Zhang L, Gao BS, Wan YG, Zhang XH, Chen B, Wang YT, Sun N, Fu YW.

Clin Transl Oncol. 2015 Jan;17(1):41-9. doi: 10.1007/s12094-014-1195-5. Epub 2014 Jul 2.


microRNA-150 inhibits human CD133-positive liver cancer stem cells through negative regulation of the transcription factor c-Myb.

Zhang J, Luo N, Luo Y, Peng Z, Zhang T, Li S.

Int J Oncol. 2012 Mar;40(3):747-56. doi: 10.3892/ijo.2011.1242. Epub 2011 Oct 24.


BMI1 sustains human glioblastoma multiforme stem cell renewal.

Abdouh M, Facchino S, Chatoo W, Balasingam V, Ferreira J, Bernier G.

J Neurosci. 2009 Jul 15;29(28):8884-96. doi: 10.1523/JNEUROSCI.0968-09.2009.


Essential role for activation of the Polycomb group (PcG) protein chromatin silencing pathway in metastatic prostate cancer.

Berezovska OP, Glinskii AB, Yang Z, Li XM, Hoffman RM, Glinsky GV.

Cell Cycle. 2006 Aug;5(16):1886-901. Epub 2006 Aug 15.


SOX2 plays a critical role in EGFR-mediated self-renewal of human prostate cancer stem-like cells.

Rybak AP, Tang D.

Cell Signal. 2013 Dec;25(12):2734-42. doi: 10.1016/j.cellsig.2013.08.041. Epub 2013 Sep 13.


MicroRNA-101 inhibits human hepatocellular carcinoma progression through EZH2 downregulation and increased cytostatic drug sensitivity.

Xu L, Beckebaum S, Iacob S, Wu G, Kaiser GM, Radtke A, Liu C, Kabar I, Schmidt HH, Zhang X, Lu M, Cicinnati VR.

J Hepatol. 2014 Mar;60(3):590-8. doi: 10.1016/j.jhep.2013.10.028. Epub 2013 Nov 6.


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