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Zscan4 restores the developmental potency of embryonic stem cells.

Amano T, Hirata T, Falco G, Monti M, Sharova LV, Amano M, Sheer S, Hoang HG, Piao Y, Stagg CA, Yamamizu K, Akiyama T, Ko MS.

Nat Commun. 2013;4:1966. doi: 10.1038/ncomms2966.


Zscan4 regulates telomere elongation and genomic stability in ES cells.

Zalzman M, Falco G, Sharova LV, Nishiyama A, Thomas M, Lee SL, Stagg CA, Hoang HG, Yang HT, Indig FE, Wersto RP, Ko MS.

Nature. 2010 Apr 8;464(7290):858-63. doi: 10.1038/nature08882. Epub 2010 Mar 24.


Repression of global protein synthesis by Eif1a-like genes that are expressed specifically in the two-cell embryos and the transient Zscan4-positive state of embryonic stem cells.

Hung SS, Wong RC, Sharov AA, Nakatake Y, Yu H, Ko MS.

DNA Res. 2013 Aug;20(4):391-402. doi: 10.1093/dnares/dst018. Epub 2013 May 5.


Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells.

Dan J, Li M, Yang J, Li J, Okuka M, Ye X, Liu L.

Sci Rep. 2013 Dec 13;3:3492. doi: 10.1038/srep03492.


Different telomere-length dynamics at the inner cell mass versus established embryonic stem (ES) cells.

Varela E, Schneider RP, Ortega S, Blasco MA.

Proc Natl Acad Sci U S A. 2011 Sep 13;108(37):15207-12. doi: 10.1073/pnas.1105414108. Epub 2011 Aug 24.


Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation.

Jiang J, Lv W, Ye X, Wang L, Zhang M, Yang H, Okuka M, Zhou C, Zhang X, Liu L, Li J.

Cell Res. 2013 Jan;23(1):92-106. doi: 10.1038/cr.2012.157. Epub 2012 Nov 13.


Role of Zscan4 in secondary murine iPSC derivation mediated by protein extracts of ESC or iPSC.

Kwon YW, Paek JS, Cho HJ, Lee CS, Lee HJ, Park IH, Roh TY, Kang CM, Yang HM, Park YB, Kim HS.

Biomaterials. 2015 Aug;59:102-15. doi: 10.1016/j.biomaterials.2015.03.031. Epub 2015 May 15.


Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells.

Storm MP, Kumpfmueller B, Bone HK, Buchholz M, Sanchez Ripoll Y, Chaudhuri JB, Niwa H, Tosh D, Welham MJ.

PLoS One. 2014 Mar 3;9(3):e89821. doi: 10.1371/journal.pone.0089821. eCollection 2014.


Zscan4: a novel gene expressed exclusively in late 2-cell embryos and embryonic stem cells.

Falco G, Lee SL, Stanghellini I, Bassey UC, Hamatani T, Ko MS.

Dev Biol. 2007 Jul 15;307(2):539-50. Epub 2007 May 8.


Inflammation increases cells expressing ZSCAN4 and progenitor cell markers in the adult pancreas.

Ko SB, Azuma S, Yokoyama Y, Yamamoto A, Kyokane K, Niida S, Ishiguro H, Ko MS.

Am J Physiol Gastrointest Liver Physiol. 2013 Jun 15;304(12):G1103-16. doi: 10.1152/ajpgi.00299.2012. Epub 2013 Apr 18.


Nuclear transfer reprogramming does not improve the low developmental potency of embryonic stem cells induced by long-term culture.

Amano T, Gertsenstein M, Nagy A, Kurihara H, Suzuki H.

Reproduction. 2006 Aug;132(2):257-63.


Acceptance of embryonic stem cells by a wide developmental range of mouse tetraploid embryos.

Lin CJ, Amano T, Zhang J, Chen YE, Tian XC.

Biol Reprod. 2010 Aug 1;83(2):177-84. doi: 10.1095/biolreprod.110.084707. Epub 2010 Apr 21.


Efficient production of mice from embryonic stem cells injected into four- or eight-cell embryos by piezo micromanipulation.

Huang J, Deng K, Wu H, Liu Z, Chen Z, Cao S, Zhou L, Ye X, Keefe DL, Liu L.

Stem Cells. 2008 Jul;26(7):1883-90. doi: 10.1634/stemcells.2008-0164. Epub 2008 May 8.


Generation of completely embryonic stem cell-derived mutant mice using tetraploid blastocyst injection.

Wang ZQ, Kiefer F, Urbánek P, Wagner EF.

Mech Dev. 1997 Mar;62(2):137-45.


Transcriptional heterogeneity in mouse embryonic stem cells.

Tanaka TS.

Reprod Fertil Dev. 2009;21(1):67-75. Review.


Retinoic Acid Specifically Enhances Embryonic Stem Cell Metastate Marked by Zscan4.

Tagliaferri D, De Angelis MT, Russo NA, Marotta M, Ceccarelli M, Del Vecchio L, De Felice M, Falco G.

PLoS One. 2016 Feb 3;11(2):e0147683. doi: 10.1371/journal.pone.0147683. eCollection 2016.


Increasing the cell number of host tetraploid embryos can improve the production of mice derived from embryonic stem cells.

Ohta H, Sakaide Y, Yamagata K, Wakayama T.

Biol Reprod. 2008 Sep;79(3):486-92. doi: 10.1095/biolreprod.107.067116. Epub 2008 May 7.


Expression profiling in transgenic FVB/N embryonic stem cells overexpressing STAT3.

Cinelli P, Casanova EA, Uhlig S, Lochmatter P, Matsuda T, Yokota T, Rülicke T, Ledermann B, Bürki K.

BMC Dev Biol. 2008 May 23;8:57. doi: 10.1186/1471-213X-8-57.


Tcstv1 and Tcstv3 elongate telomeres of mouse ES cells.

Zhang Q, Dan J, Wang H, Guo R, Mao J, Fu H, Wei X, Liu L.

Sci Rep. 2016 Jan 27;6:19852. doi: 10.1038/srep19852.


iPS cells produce viable mice through tetraploid complementation.

Zhao XY, Li W, Lv Z, Liu L, Tong M, Hai T, Hao J, Guo CL, Ma QW, Wang L, Zeng F, Zhou Q.

Nature. 2009 Sep 3;461(7260):86-90. doi: 10.1038/nature08267.

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