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Optimizing combinations of flavonoids deriving from astragali radix in activating the regulatory element of erythropoietin by a feedback system control scheme.

Yu H, Zhang WL, Ding X, Zheng KY, Ho CM, Tsim KW, Lee YK.

Evid Based Complement Alternat Med. 2013;2013:541436. doi: 10.1155/2013/541436. Epub 2013 Apr 30.


Flavonoids from Radix Astragali induce the expression of erythropoietin in cultured cells: a signaling mediated via the accumulation of hypoxia-inducible factor-1α.

Zheng KY, Choi RC, Cheung AW, Guo AJ, Bi CW, Zhu KY, Fu Q, Du Y, Zhang WL, Zhan JY, Duan R, Lau DT, Dong TT, Tsim KW.

J Agric Food Chem. 2011 Mar 9;59(5):1697-704. doi: 10.1021/jf104018u. Epub 2011 Feb 10.


A novel combination of four flavonoids derived from Astragali Radix relieves the symptoms of cyclophosphamide-induced anemic rats.

Zhang L, Gong AG, Riaz K, Deng JY, Ho CM, Lin HQ, Dong TT, Lee YK, Tsim KW.

FEBS Open Bio. 2017 Jan 28;7(3):318-323. doi: 10.1002/2211-5463.12146. eCollection 2017 Mar.


Absorption and metabolism of Astragali radix decoction: in silico, in vitro, and a case study in vivo.

Xu F, Zhang Y, Xiao S, Lu X, Yang D, Yang X, Li C, Shang M, Tu P, Cai S.

Drug Metab Dispos. 2006 Jun;34(6):913-24. Epub 2006 Feb 28.


Hydrolysis of Glycosidic Flavonoids during the Preparation of Danggui Buxue Tang: An Outcome of Moderate Boiling of Chinese Herbal Mixture.

Zhang WL, Chen JP, Lam KY, Zhan JY, Yao P, Dong TT, Tsim KW.

Evid Based Complement Alternat Med. 2014;2014:608721. doi: 10.1155/2014/608721. Epub 2014 Mar 16.


The expression of erythropoietin triggered by danggui buxue tang, a Chinese herbal decoction prepared from radix Astragali and radix Angelicae Sinensis, is mediated by the hypoxia-inducible factor in cultured HEK293T cells.

Zheng KY, Choi RC, Xie HQ, Cheung AW, Guo AJ, Leung KW, Chen VP, Bi CW, Zhu KY, Chan GK, Fu Q, Lau DT, Dong TT, Zhao KJ, Tsim KW.

J Ethnopharmacol. 2010 Oct 28;132(1):259-67. doi: 10.1016/j.jep.2010.08.029. Epub 2010 Aug 17.


The membrane permeability of Astragali Radix-derived formononetin and calycosin is increased by Angelicae Sinensis Radix in Caco-2 cells: a synergistic action of an ancient herbal decoction Danggui Buxue Tang.

Zheng KY, Choi RC, Guo AJ, Bi CW, Zhu KY, Du CY, Zhang ZX, Lau DT, Dong TT, Tsim KW.

J Pharm Biomed Anal. 2012 Nov;70:671-9. doi: 10.1016/j.jpba.2012.05.018. Epub 2012 May 31.


Isolation and purification of flavonoid glucosides from Radix Astragali by high-speed counter-current chromatography.

Xiao W, Han L, Shi B.

J Chromatogr B Analyt Technol Biomed Life Sci. 2009 Mar 15;877(8-9):697-702. doi: 10.1016/j.jchromb.2009.01.034. Epub 2009 Jan 31.


Calycosin orchestrates the functions of Danggui Buxue Tang, a Chinese herbal decoction composing of Astragali Radix and Angelica Sinensis Radix: An evaluation by using calycosin-knock out herbal extract.

Gong AG, Li N, Lau KM, Lee PS, Yan L, Xu ML, Lam CT, Kong AY, Lin HQ, Dong TT, Tsim KW.

J Ethnopharmacol. 2015 Jun 20;168:150-7. doi: 10.1016/j.jep.2015.03.033. Epub 2015 Mar 19. Review.


Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment?

Zhang WL, Choi RC, Zhan JY, Chen JP, Luk WK, Yao P, Dong TT, Tsim KW.

Phytomedicine. 2013 Sep 15;20(12):1076-81. doi: 10.1016/j.phymed.2013.04.016. Epub 2013 Jun 6.


Identification of Angelica oil as a suppressor for the biological properties of Danggui Buxue Tang: a Chinese herbal decoction composes of Astragali Radix and Angelica Sinensis Radix.

Zhan JY, Zheng KY, Zhang WL, Chen JP, Yao P, Bi CW, Dong TT, Tsim KW.

J Ethnopharmacol. 2014 Jul 3;154(3):825-31. doi: 10.1016/j.jep.2014.05.007. Epub 2014 May 14.


Tissue distribution of six major bio-active components after oral administration of Zhenqi Fuzheng capsules to rats using ultra-pressure liquid chromatography-tandem mass spectrometry.

Liu XH, Zhu RJ, Hu F, Guo L, Yang YL, Feng SL.

J Chromatogr B Analyt Technol Biomed Life Sci. 2015 Apr 1;986-987:44-53. doi: 10.1016/j.jchromb.2015.01.033. Epub 2015 Feb 9.


Identification and determination of flavonoids in astragali radix by high performance liquid chromatography coupled with DAD and ESI-MS detection.

Lv YW, Hu W, Wang YL, Huang LF, He YB, Xie XZ.

Molecules. 2011 Mar 9;16(3):2293-303. doi: 10.3390/molecules16032293.


Chemical and biological assessment of a chinese herbal decoction containing Radix Astragali and Radix Angelicae Sinensis: Determination of drug ratio in having optimized properties.

Dong TT, Zhao KJ, Gao QT, Ji ZN, Zhu TT, Li J, Duan R, Cheung AW, Tsim KW.

J Agric Food Chem. 2006 Apr 5;54(7):2767-74.


[Studies on effects of calycosin-7-O-β-D-glucoside on prim-O-glucosylcimifugin and cimifugin in vivo pharmacokinetics].

Zhao XL, Liu L, Di LQ, Li JS, Kang A.

Zhongguo Zhong Yao Za Zhi. 2014 Dec;39(23):4669-74. Chinese.


Ferulic acid enhances the chemical and biological properties of astragali radix: a stimulator for danggui buxue tang, an ancient Chinese herbal decoction.

Zheng KY, Zhang ZX, Du CY, Zhang WL, Bi CW, Choi RC, Dong TT, Tsim KW.

Planta Med. 2014 Feb;80(2-3):159-64. doi: 10.1055/s-0033-1360314. Epub 2014 Jan 31.


Liquid chromatography-electrospray ionization mass spectrometry study of the flavonoids of the roots of Astragalus mongholicus and A. membranaceus.

Lin LZ, He XG, Lindenmaier M, Nolan G, Yang J, Cleary M, Qiu SX, Cordell GA.

J Chromatogr A. 2000 Apr 21;876(1-2):87-95.


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