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Items: 1 to 20 of 73

1.

Coexpression of CPR from various origins enhances biotransformation activity of human CYPs in S. pombe.

Neunzig I, Widjaja M, Peters FT, Maurer HH, Hehn A, Bourgaud F, Bureik M.

Appl Biochem Biotechnol. 2013 Aug;170(7):1751-66. doi: 10.1007/s12010-013-0303-2. Epub 2013 Jun 6.

PMID:
23737303
2.

Establishment of a yeast system that stably expresses human cytochrome P450 reductase: application for the study of drug metabolism of cytochrome P450s in vitro.

Cheng J, Wan DF, Gu JR, Gong Y, Yang SL, Hao DC, Yang L.

Protein Expr Purif. 2006 Jun;47(2):467-76. Epub 2005 Dec 20.

PMID:
16434211
3.

Convenient gram-scale metabolite synthesis by engineered fission yeast strains expressing functional human P450 systems.

Drăgan CA, Peters FT, Bour P, Schwaninger AE, Schaan SM, Neunzig I, Widjaja M, Zapp J, Kraemer T, Maurer HH, Bureik M.

Appl Biochem Biotechnol. 2011 Apr;163(8):965-80. doi: 10.1007/s12010-010-9100-3. Epub 2010 Oct 7.

PMID:
20927605
4.

Bioconversion of deoxypodophyllotoxin into epipodophyllotoxin in E. coli using human cytochrome P450 3A4.

Vasilev NP, Julsing MK, Koulman A, Clarkson C, Woerdenbag HJ, Ionkova I, Bos R, Jaroszewski JW, Kayser O, Quax WJ.

J Biotechnol. 2006 Nov 10;126(3):383-93. Epub 2006 Jun 5.

PMID:
16753237
5.

Coexpression of genetically engineered fused enzyme between yeast NADPH-P450 reductase and human cytochrome P450 3A4 and human cytochrome b5 in yeast.

Hayashi K, Sakaki T, Kominami S, Inouye K, Yabusaki Y.

Arch Biochem Biophys. 2000 Sep 1;381(1):164-70.

PMID:
11019832
7.

Role of human cytochrome P450 3A4 in metabolism of medroxyprogesterone acetate.

Kobayashi K, Mimura N, Fujii H, Minami H, Sasaki Y, Shimada N, Chiba K.

Clin Cancer Res. 2000 Aug;6(8):3297-303.

8.

In vitro metabolism of nobiletin, a polymethoxy-flavonoid, by human liver microsomes and cytochrome P450.

Koga N, Ohta C, Kato Y, Haraguchi K, Endo T, Ogawa K, Ohta H, Yano M.

Xenobiotica. 2011 Nov;41(11):927-33. doi: 10.3109/00498254.2011.593208. Epub 2011 Jul 5.

PMID:
21726170
9.

Multiple cytochrome P-450s involved in the metabolism of terbinafine suggest a limited potential for drug-drug interactions.

Vickers AE, Sinclair JR, Zollinger M, Heitz F, Glänzel U, Johanson L, Fischer V.

Drug Metab Dispos. 1999 Sep;27(9):1029-38.

10.

Metabolism of the active metabolite of quetiapine, N-desalkylquetiapine in vitro.

Bakken GV, Molden E, Knutsen K, Lunder N, Hermann M.

Drug Metab Dispos. 2012 Sep;40(9):1778-84. doi: 10.1124/dmd.112.045237. Epub 2012 Jun 11.

11.

Metabolism of risperidone to 9-hydroxyrisperidone by human cytochromes P450 2D6 and 3A4.

Fang J, Bourin M, Baker GB.

Naunyn Schmiedebergs Arch Pharmacol. 1999 Feb;359(2):147-51.

PMID:
10048600
12.

Rapid characterization of the major drug-metabolizing human hepatic cytochrome P-450 enzymes expressed in Escherichia coli.

McGinnity DF, Griffin SJ, Moody GC, Voice M, Hanlon S, Friedberg T, Riley RJ.

Drug Metab Dispos. 1999 Sep;27(9):1017-23.

13.

Effects of human cytochrome b5 on CYP3A4 activity and stability in vivo.

Voice MW, Zhang Y, Wolf CR, Burchell B, Friedberg T.

Arch Biochem Biophys. 1999 Jun 1;366(1):116-24.

PMID:
10334871
14.

Roles of NADPH-P450 reductase and apo- and holo-cytochrome b5 on xenobiotic oxidations catalyzed by 12 recombinant human cytochrome P450s expressed in membranes of Escherichia coli.

Yamazaki H, Nakamura M, Komatsu T, Ohyama K, Hatanaka N, Asahi S, Shimada N, Guengerich FP, Shimada T, Nakajima M, Yokoi T.

Protein Expr Purif. 2002 Apr;24(3):329-37.

PMID:
11922748
15.

Coexpression of a human P450 (CYP3A4) and P450 reductase generates a highly functional monooxygenase system in Escherichia coli.

Blake JA, Pritchard M, Ding S, Smith GC, Burchell B, Wolf CR, Friedberg T.

FEBS Lett. 1996 Nov 18;397(2-3):210-4.

16.

Engineering of human CYP3A enzymes by combination of activating polymorphic variants.

Neunzig I, Widjaja M, Drăgan CA, Peters FT, Maurer HH, Bureik M.

Appl Biochem Biotechnol. 2012 Oct;168(4):785-96. doi: 10.1007/s12010-012-9819-0. Epub 2012 Aug 17.

PMID:
22899011
17.

Metabolism of 7-benzyloxy-4-trifluoromethyl-coumarin by human hepatic cytochrome P450 isoforms.

Renwick AB, Surry D, Price RJ, Lake BG, Evans DC.

Xenobiotica. 2000 Oct;30(10):955-69.

PMID:
11315104
18.

A fission yeast-based test system for the determination of IC50 values of anti-prostate tumor drugs acting on CYP21.

Drăgan CA, Hartmann RW, Bureik M.

J Enzyme Inhib Med Chem. 2006 Oct;21(5):547-56.

PMID:
17194026
19.

Oxidation of 3-aminobenzanthrone, a human metabolite of carcinogenic environmental pollutant 3-nitrobenzanthrone, by cytochromes P450 - similarity between human and rat enzymes.

Mizerovska J, Dracinska H, Arlt VM, Schmeiser HH, Frei E, Stiborova M.

Neuro Endocrinol Lett. 2009;30 Suppl 1:52-9.

PMID:
20027145
20.

Comparative metabolic capabilities of CYP3A4, CYP3A5, and CYP3A7.

Williams JA, Ring BJ, Cantrell VE, Jones DR, Eckstein J, Ruterbories K, Hamman MA, Hall SD, Wrighton SA.

Drug Metab Dispos. 2002 Aug;30(8):883-91.

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