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Identification of a small molecule 1,4-bis-[4-(3-phenoxy-propoxy)-but-2-ynyl]-piperazine as a novel inhibitor of the transcription factor p53.

Liu X, Zhang Y, Tong M, Liu XY, Luo GZ, Xie DF, Ren SF, Bai DH, Wang L, Zhou Q, Wang XJ.

Acta Pharmacol Sin. 2013 Jun;34(6):805-10. doi: 10.1038/aps.2013.61.


Activation of p53 by nutlin leads to rapid differentiation of human embryonic stem cells.

Maimets T, Neganova I, Armstrong L, Lako M.

Oncogene. 2008 Sep 11;27(40):5277-87. doi: 10.1038/onc.2008.166. Epub 2008 Jun 2.


Ionizing radiation down-regulates p53 protein in primary Egr-1-/- mouse embryonic fibroblast cells causing enhanced resistance to apoptosis.

Das A, Chendil D, Dey S, Mohiuddin M, Mohiuddin M, Milbrandt J, Rangnekar VM, Ahmed MM.

J Biol Chem. 2001 Feb 2;276(5):3279-86. Epub 2000 Oct 16.


A natural small molecule harmine inhibits angiogenesis and suppresses tumour growth through activation of p53 in endothelial cells.

Dai F, Chen Y, Song Y, Huang L, Zhai D, Dong Y, Lai L, Zhang T, Li D, Pang X, Liu M, Yi Z.

PLoS One. 2012;7(12):e52162. doi: 10.1371/journal.pone.0052162. Epub 2012 Dec 27.


Efficient activation of p53 pathway in A549 cells exposed to L2, a novel compound targeting p53-MDM2 interaction.

Zhang L, Zhang J, Hu C, Cao J, Zhou X, Hu Y, He Q, Yang B.

Anticancer Drugs. 2009 Jul;20(6):416-24.


The oncogene DEK promotes leukemic cell survival and is downregulated by both Nutlin-3 and chlorambucil in B-chronic lymphocytic leukemic cells.

Secchiero P, Voltan R, di Iasio MG, Melloni E, Tiribelli M, Zauli G.

Clin Cancer Res. 2010 Mar 15;16(6):1824-33. doi: 10.1158/1078-0432.CCR-09-3031. Epub 2010 Mar 9.


A portrait of cisplatin-induced transcriptional changes in mouse embryonic stem cells reveals a dominant p53-like response.

Kruse JJ, Svensson JP, Huigsloot M, Giphart-Gassler M, Schoonen WG, Polman JE, Jean Horbach G, van de Water B, Vrieling H.

Mutat Res. 2007 Apr 1;617(1-2):58-70. Epub 2007 Feb 2.


LYG-202 inhibits the proliferation of human colorectal carcinoma HCT-116 cells through induction of G1/S cell cycle arrest and apoptosis via p53 and p21(WAF1/Cip1) expression.

Liu W, Dai Q, Lu N, Wei L, Ha J, Rong J, Mu R, You Q, Li Z, Guo Q.

Biochem Cell Biol. 2011 Jun;89(3):287-98. doi: 10.1139/O10-162. Epub 2011 Apr 14.


G protein coupled receptors in embryonic stem cells: a role for Gs-alpha signaling.

Layden BT, Newman M, Chen F, Fisher A, Lowe WL Jr.

PLoS One. 2010 Feb 8;5(2):e9105. doi: 10.1371/journal.pone.0009105.


RITA inhibits multiple myeloma cell growth through induction of p53-mediated caspase-dependent apoptosis and synergistically enhances nutlin-induced cytotoxic responses.

Saha MN, Jiang H, Mukai A, Chang H.

Mol Cancer Ther. 2010 Nov;9(11):3041-51. doi: 10.1158/1535-7163.MCT-10-0471. Epub 2010 Nov 9.


Porphyrin homeostasis maintained by ABCG2 regulates self-renewal of embryonic stem cells.

Susanto J, Lin YH, Chen YN, Shen CR, Yan YT, Tsai ST, Chen CH, Shen CN.

PLoS One. 2008;3(12):e4023. doi: 10.1371/journal.pone.0004023. Epub 2008 Dec 24.


Pharmacological activation of the p53 pathway by nutlin-3 exerts anti-tumoral effects in medulloblastomas.

Künkele A, De Preter K, Heukamp L, Thor T, Pajtler KW, Hartmann W, Mittelbronn M, Grotzer MA, Deubzer HE, Speleman F, Schramm A, Eggert A, Schulte JH.

Neuro Oncol. 2012 Jul;14(7):859-69. doi: 10.1093/neuonc/nos115. Epub 2012 May 16.


HSP27 regulates p53 transcriptional activity in doxorubicin-treated fibroblasts and cardiac H9c2 cells: p21 upregulation and G2/M phase cell cycle arrest.

Venkatakrishnan CD, Dunsmore K, Wong H, Roy S, Sen CK, Wani A, Zweier JL, Ilangovan G.

Am J Physiol Heart Circ Physiol. 2008 Apr;294(4):H1736-44. doi: 10.1152/ajpheart.91507.2007. Epub 2008 Feb 8.


Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures.

Cohen JR, Resnick DZ, Niewiadomski P, Dong H, Liau LM, Waschek JA.

BMC Cancer. 2010 Dec 9;10:676. doi: 10.1186/1471-2407-10-676.


PKA and cAMP stimulate proliferation of mouse embryonic stem cells by elevating GLUT1 expression mediated by the NF-κB and CREB/CBP signaling pathways.

Kim MO, Lee YJ, Park JH, Ryu JM, Yun SP, Han HJ.

Biochim Biophys Acta. 2012 Oct;1820(10):1636-46. doi: 10.1016/j.bbagen.2012.05.008. Epub 2012 May 29.


Ultraviolet radiation down-regulates expression of the cell-cycle inhibitor p21WAF1/CIP1 in human cancer cells independently of p53.

Wang JA, Fan S, Yuan RQ, Ma YX, Meng Q, Goldberg ID, Rosen EM.

Int J Radiat Biol. 1999 Mar;75(3):301-16.


Activation of the p53 pathway by the MDM2 inhibitor nutlin-3a overcomes BCL2 overexpression in a preclinical model of diffuse large B-cell lymphoma associated with t(14;18)(q32;q21).

Drakos E, Singh RR, Rassidakis GZ, Schlette E, Li J, Claret FX, Ford RJ Jr, Vega F, Medeiros LJ.

Leukemia. 2011 May;25(5):856-67. doi: 10.1038/leu.2011.28. Epub 2011 Mar 11.


All-trans retinoic acid inhibits mesangial cell proliferation by up-regulating p21Waf1/Cip1 and p27Kip1 and down-regulating Skp2.

Su B, Chen X, Zhong C, Guo N, He J, Fan Y.

J Nephrol. 2012 Nov-Dec;25(6):1031-40. doi: 10.5301/jn.5000090.


Sirtuin 1 facilitates generation of induced pluripotent stem cells from mouse embryonic fibroblasts through the miR-34a and p53 pathways.

Lee YL, Peng Q, Fong SW, Chen AC, Lee KF, Ng EH, Nagy A, Yeung WS.

PLoS One. 2012;7(9):e45633. doi: 10.1371/journal.pone.0045633. Epub 2012 Sep 21.


Stimulation of ES-cell-derived cardiomyogenesis and neonatal cardiac cell proliferation by reactive oxygen species and NADPH oxidase.

Buggisch M, Ateghang B, Ruhe C, Strobel C, Lange S, Wartenberg M, Sauer H.

J Cell Sci. 2007 Mar 1;120(Pt 5):885-94. Epub 2007 Feb 13.

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