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Items: 1 to 20 of 277

1.

Identification of a new dengue virus inhibitor that targets the viral NS4B protein and restricts genomic RNA replication.

van Cleef KW, Overheul GJ, Thomassen MC, Kaptein SJ, Davidson AD, Jacobs M, Neyts J, van Kuppeveld FJ, van Rij RP.

Antiviral Res. 2013 Aug;99(2):165-71. doi: 10.1016/j.antiviral.2013.05.011. Epub 2013 Jun 2.

PMID:
23735301
2.

Inhibition of dengue virus by targeting viral NS4B protein.

Xie X, Wang QY, Xu HY, Qing M, Kramer L, Yuan Z, Shi PY.

J Virol. 2011 Nov;85(21):11183-95. doi: 10.1128/JVI.05468-11. Epub 2011 Aug 24.

3.

Escape Mutations in NS4B Render Dengue Virus Insensitive to the Antiviral Activity of the Paracetamol Metabolite AM404.

van Cleef KW, Overheul GJ, Thomassen MC, Marjakangas JM, van Rij RP.

Antimicrob Agents Chemother. 2016 Mar 25;60(4):2554-7. doi: 10.1128/AAC.02462-15. Print 2016 Apr.

4.

A Combined Genetic-Proteomic Approach Identifies Residues within Dengue Virus NS4B Critical for Interaction with NS3 and Viral Replication.

Chatel-Chaix L, Fischl W, Scaturro P, Cortese M, Kallis S, Bartenschlager M, Fischer B, Bartenschlager R.

J Virol. 2015 Jul;89(14):7170-86. doi: 10.1128/JVI.00867-15. Epub 2015 Apr 29.

5.

Novel antiviral activity of bromocriptine against dengue virus replication.

Kato F, Ishida Y, Oishi S, Fujii N, Watanabe S, Vasudevan SG, Tajima S, Takasaki T, Suzuki Y, Ichiyama K, Yamamoto N, Yoshii K, Takashima I, Kobayashi T, Miura T, Igarashi T, Hishiki T.

Antiviral Res. 2016 Jul;131:141-7. doi: 10.1016/j.antiviral.2016.04.014. Epub 2016 May 12.

6.

Identification of a Pyridoxine-Derived Small-Molecule Inhibitor Targeting Dengue Virus RNA-Dependent RNA Polymerase.

Xu HT, Colby-Germinario SP, Hassounah S, Quashie PK, Han Y, Oliveira M, Stranix BR, Wainberg MA.

Antimicrob Agents Chemother. 2015 Nov 16;60(1):600-8. doi: 10.1128/AAC.02203-15. Print 2016 Jan.

7.

A novel dengue virus inhibitor, BP13944, discovered by high-throughput screening with dengue virus replicon cells selects for resistance in the viral NS2B/NS3 protease.

Yang CC, Hu HS, Wu RH, Wu SH, Lee SJ, Jiaang WT, Chern JH, Huang ZS, Wu HN, Chang CM, Yueh A.

Antimicrob Agents Chemother. 2014;58(1):110-9. doi: 10.1128/AAC.01281-13. Epub 2013 Oct 21.

8.

Mutation of Putative N-Glycosylation Sites on Dengue Virus NS4B Decreases RNA Replication.

Naik NG, Wu HN.

J Virol. 2015 Jul;89(13):6746-60. doi: 10.1128/JVI.00423-15. Epub 2015 Apr 15.

9.

Discovery of Dengue Virus NS4B Inhibitors.

Wang QY, Dong H, Zou B, Karuna R, Wan KF, Zou J, Susila A, Yip A, Shan C, Yeo KL, Xu H, Ding M, Chan WL, Gu F, Seah PG, Liu W, Lakshminarayana SB, Kang C, Lescar J, Blasco F, Smith PW, Shi PY.

J Virol. 2015 Aug;89(16):8233-44.

10.

Policresulen, a novel NS2B/NS3 protease inhibitor, effectively inhibits the replication of DENV2 virus in BHK-21 cells.

Wu DW, Mao F, Ye Y, Li J, Xu CL, Luo XM, Chen J, Shen X.

Acta Pharmacol Sin. 2015 Sep;36(9):1126-36. doi: 10.1038/aps.2015.56. Epub 2015 Aug 17.

11.

Mutagenesis of Dengue Virus Protein NS2A Revealed a Novel Domain Responsible for Virus-Induced Cytopathic Effect and Interactions between NS2A and NS2B Transmembrane Segments.

Wu RH, Tsai MH, Tsai KN, Tian JN, Wu JS, Wu SY, Chern JH, Chen CH, Yueh A.

J Virol. 2017 May 26;91(12). pii: e01836-16. doi: 10.1128/JVI.01836-16. Print 2017 Jun 15.

12.

Narasin, a novel antiviral compound that blocks dengue virus protein expression.

Low JS, Wu KX, Chen KC, Ng MM, Chu JJ.

Antivir Ther. 2011;16(8):1203-18. doi: 10.3851/IMP1884.

PMID:
22155902
13.

Characterization of the activity of 2'-C-methylcytidine against dengue virus replication.

Lee JC, Tseng CK, Wu YH, Kaushik-Basu N, Lin CK, Chen WC, Wu HN.

Antiviral Res. 2015 Apr;116:1-9. doi: 10.1016/j.antiviral.2015.01.002. Epub 2015 Jan 19.

PMID:
25614455
14.

Novel benzoxazole inhibitor of dengue virus replication that targets the NS3 helicase.

Byrd CM, Grosenbach DW, Berhanu A, Dai D, Jones KF, Cardwell KB, Schneider C, Yang G, Tyavanagimatt S, Harver C, Wineinger KA, Page J, Stavale E, Stone MA, Fuller KP, Lovejoy C, Leeds JM, Hruby DE, Jordan R.

Antimicrob Agents Chemother. 2013 Apr;57(4):1902-12. doi: 10.1128/AAC.02251-12. Epub 2013 Feb 12.

15.

Serotype-specific interactions among functional domains of dengue virus 2 nonstructural proteins (NS) 5 and NS3 are crucial for viral RNA replication.

Teramoto T, Balasubramanian A, Choi KH, Padmanabhan R.

J Biol Chem. 2017 Jun 9;292(23):9465-9479. doi: 10.1074/jbc.M117.775643. Epub 2017 Apr 10.

PMID:
28396347
16.

Development and characterization of a stable luciferase dengue virus for high-throughput screening.

Zou G, Xu HY, Qing M, Wang QY, Shi PY.

Antiviral Res. 2011 Jul;91(1):11-9. doi: 10.1016/j.antiviral.2011.05.001. Epub 2011 May 7.

PMID:
21575658
17.

Construction and characterization of a stable subgenomic dengue virus type 2 replicon system for antiviral compound and siRNA testing.

Ng CY, Gu F, Phong WY, Chen YL, Lim SP, Davidson A, Vasudevan SG.

Antiviral Res. 2007 Dec;76(3):222-31. Epub 2007 Jul 26.

PMID:
17662475
18.

Characterization of an efficient dengue virus replicon for development of assays of discovery of small molecules against dengue virus.

Yang CC, Tsai MH, Hu HS, Pu SY, Wu RH, Wu SH, Lin HM, Song JS, Chao YS, Yueh A.

Antiviral Res. 2013 May;98(2):228-41. doi: 10.1016/j.antiviral.2013.03.001. Epub 2013 Mar 13.

PMID:
23499649
19.

Nordihydroguaiaretic acid (NDGA) inhibits replication and viral morphogenesis of dengue virus.

Soto-Acosta R, Bautista-Carbajal P, Syed GH, Siddiqui A, Del Angel RM.

Antiviral Res. 2014 Sep;109:132-40. doi: 10.1016/j.antiviral.2014.07.002. Epub 2014 Jul 11.

PMID:
25017471
20.

Identification of a small-molecule inhibitor of dengue virus using a replicon system.

Hsu YC, Chen NC, Chen PC, Wang CC, Cheng WC, Wu HN.

Arch Virol. 2012 Apr;157(4):681-8. doi: 10.1007/s00705-012-1224-z. Epub 2012 Jan 15.

PMID:
22249364

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