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Cancer- and endotoxin-induced cachexia require intact glucocorticoid signaling in skeletal muscle.

Braun TP, Grossberg AJ, Krasnow SM, Levasseur PR, Szumowski M, Zhu XX, Maxson JE, Knoll JG, Barnes AP, Marks DL.

FASEB J. 2013 Sep;27(9):3572-82. doi: 10.1096/fj.13-230375. Epub 2013 Jun 3.


Muscle atrophy in response to cytotoxic chemotherapy is dependent on intact glucocorticoid signaling in skeletal muscle.

Braun TP, Szumowski M, Levasseur PR, Grossberg AJ, Zhu X, Agarwal A, Marks DL.

PLoS One. 2014 Sep 25;9(9):e106489. doi: 10.1371/journal.pone.0106489. eCollection 2014.


Epigallocatechin-3-gallate effectively attenuates skeletal muscle atrophy caused by cancer cachexia.

Wang H, Lai YJ, Chan YL, Li TL, Wu CJ.

Cancer Lett. 2011 Jun 1;305(1):40-9. doi: 10.1016/j.canlet.2011.02.023.


Inhibition of FoxO transcriptional activity prevents muscle fiber atrophy during cachexia and induces hypertrophy.

Reed SA, Sandesara PB, Senf SM, Judge AR.

FASEB J. 2012 Mar;26(3):987-1000. doi: 10.1096/fj.11-189977. Epub 2011 Nov 18.


Central nervous system inflammation induces muscle atrophy via activation of the hypothalamic-pituitary-adrenal axis.

Braun TP, Zhu X, Szumowski M, Scott GD, Grossberg AJ, Levasseur PR, Graham K, Khan S, Damaraju S, Colmers WF, Baracos VE, Marks DL.

J Exp Med. 2011 Nov 21;208(12):2449-63. doi: 10.1084/jem.20111020. Epub 2011 Nov 14.


A cell-autonomous role for the glucocorticoid receptor in skeletal muscle atrophy induced by systemic glucocorticoid exposure.

Watson ML, Baehr LM, Reichardt HM, Tuckermann JP, Bodine SC, Furlow JD.

Am J Physiol Endocrinol Metab. 2012 May 1;302(10):E1210-20. doi: 10.1152/ajpendo.00512.2011. Epub 2012 Feb 21.


Increase in muscle mitochondrial biogenesis does not prevent muscle loss but increased tumor size in a mouse model of acute cancer-induced cachexia.

Wang X, Pickrell AM, Zimmers TA, Moraes CT.

PLoS One. 2012;7(3):e33426. doi: 10.1371/journal.pone.0033426. Epub 2012 Mar 12.


Skeletal muscle glycoprotein 130's role in Lewis lung carcinoma-induced cachexia.

Puppa MJ, Gao S, Narsale AA, Carson JA.

FASEB J. 2014 Feb;28(2):998-1009. doi: 10.1096/fj.13-240580. Epub 2013 Oct 21.


Endogenous glucocorticoids and impaired insulin signaling are both required to stimulate muscle wasting under pathophysiological conditions in mice.

Hu Z, Wang H, Lee IH, Du J, Mitch WE.

J Clin Invest. 2009 Oct;119(10):3059-69. doi: 10.1172/JCI38770. Epub 2009 Sep 14.


Elevated expression of activins promotes muscle wasting and cachexia.

Chen JL, Walton KL, Winbanks CE, Murphy KT, Thomson RE, Makanji Y, Qian H, Lynch GS, Harrison CA, Gregorevic P.

FASEB J. 2014 Apr;28(4):1711-23. doi: 10.1096/fj.13-245894. Epub 2013 Dec 30.


Hypothalamo-pituitary and immune-dependent adrenal regulation during systemic inflammation.

Kanczkowski W, Alexaki VI, Tran N, Großklaus S, Zacharowski K, Martinez A, Popovics P, Block NL, Chavakis T, Schally AV, Bornstein SR.

Proc Natl Acad Sci U S A. 2013 Sep 3;110(36):14801-6. doi: 10.1073/pnas.1313945110. Epub 2013 Aug 19.


Myostatin gene inactivation prevents skeletal muscle wasting in cancer.

Gallot YS, Durieux AC, Castells J, Desgeorges MM, Vernus B, Plantureux L, Rémond D, Jahnke VE, Lefai E, Dardevet D, Nemoz G, Schaeffer L, Bonnieu A, Freyssenet DG.

Cancer Res. 2014 Dec 15;74(24):7344-56. doi: 10.1158/0008-5472.CAN-14-0057. Epub 2014 Oct 21.


Antibody-directed myostatin inhibition enhances muscle mass and function in tumor-bearing mice.

Murphy KT, Chee A, Gleeson BG, Naim T, Swiderski K, Koopman R, Lynch GS.

Am J Physiol Regul Integr Comp Physiol. 2011 Sep;301(3):R716-26. doi: 10.1152/ajpregu.00121.2011. Epub 2011 Jun 15.


Glucocorticoid-induced skeletal muscle atrophy.

Schakman O, Kalista S, Barbé C, Loumaye A, Thissen JP.

Int J Biochem Cell Biol. 2013 Oct;45(10):2163-72. doi: 10.1016/j.biocel.2013.05.036. Epub 2013 Jun 24. Review.


Inflammation- and tumor-induced anorexia and weight loss require MyD88 in hematopoietic/myeloid cells but not in brain endothelial or neural cells.

Ruud J, Wilhelms DB, Nilsson A, Eskilsson A, Tang YJ, Ströhle P, Caesar R, Schwaninger M, Wunderlich T, Bäckhed F, Engblom D, Blomqvist A.

FASEB J. 2013 May;27(5):1973-80. doi: 10.1096/fj.12-225433. Epub 2013 Feb 8.


Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice.

Porporato PE, Filigheddu N, Reano S, Ferrara M, Angelino E, Gnocchi VF, Prodam F, Ronchi G, Fagoonee S, Fornaro M, Chianale F, Baldanzi G, Surico N, Sinigaglia F, Perroteau I, Smith RG, Sun Y, Geuna S, Graziani A.

J Clin Invest. 2013 Feb;123(2):611-22. doi: 10.1172/JCI39920. Epub 2013 Jan 2.


Endotoxin-induced skeletal muscle wasting is prevented by angiotensin-(1-7) through a p38 MAPK-dependent mechanism.

Morales MG, Olguín H, Di Capua G, Brandan E, Simon F, Cabello-Verrugio C.

Clin Sci (Lond). 2015 Sep;129(6):461-76. doi: 10.1042/CS20140840. Epub 2015 May 19.


Genetic deletion of myostatin from the heart prevents skeletal muscle atrophy in heart failure.

Heineke J, Auger-Messier M, Xu J, Sargent M, York A, Welle S, Molkentin JD.

Circulation. 2010 Jan 26;121(3):419-25. doi: 10.1161/CIRCULATIONAHA.109.882068. Epub 2010 Jan 11.


Dominant role of the MyD88-dependent signaling pathway in mediating early endotoxin-induced murine ileus.

Buchholz BM, Billiar TR, Bauer AJ.

Am J Physiol Gastrointest Liver Physiol. 2010 Aug;299(2):G531-8. doi: 10.1152/ajpgi.00060.2010. Epub 2010 May 27.


Pre-cachexia in patients with stages I-III non-small cell lung cancer: systemic inflammation and functional impairment without activation of skeletal muscle ubiquitin proteasome system.

Op den Kamp CM, Langen RC, Minnaard R, Kelders MC, Snepvangers FJ, Hesselink MK, Dingemans AC, Schols AM.

Lung Cancer. 2012 Apr;76(1):112-7. doi: 10.1016/j.lungcan.2011.09.012. Epub 2011 Oct 20.

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