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Items: 1 to 20 of 780

1.

Spinal sigma-1 receptors activate NADPH oxidase 2 leading to the induction of pain hypersensitivity in mice and mechanical allodynia in neuropathic rats.

Choi SR, Roh DH, Yoon SY, Kang SY, Moon JY, Kwon SG, Choi HS, Han HJ, Beitz AJ, Oh SB, Lee JH.

Pharmacol Res. 2013 Aug;74:56-67. doi: 10.1016/j.phrs.2013.05.004. Epub 2013 Jun 1.

PMID:
23732704
2.

Intrathecal injection of the sigma(1) receptor antagonist BD1047 blocks both mechanical allodynia and increases in spinal NR1 expression during the induction phase of rodent neuropathic pain.

Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Kim KW, Han HJ, Beitz AJ, Na HS, Lee JH.

Anesthesiology. 2008 Nov;109(5):879-89. doi: 10.1097/ALN.0b013e3181895a83.

PMID:
18946301
3.

Neuronal NOS Activates Spinal NADPH Oxidase 2 Contributing to Central Sigma-1 Receptor-Induced Pain Hypersensitivity in Mice.

Choi SR, Kwon SG, Choi HS, Han HJ, Beitz AJ, Lee JH.

Biol Pharm Bull. 2016 Dec 1;39(12):1922-1931. Epub 2016 Sep 7.

4.

Sigma-1 receptor-mediated increase in spinal p38 MAPK phosphorylation leads to the induction of mechanical allodynia in mice and neuropathic rats.

Moon JY, Roh DH, Yoon SY, Kang SY, Choi SR, Kwon SG, Choi HS, Han HJ, Beitz AJ, Lee JH.

Exp Neurol. 2013 Sep;247:383-91. doi: 10.1016/j.expneurol.2013.01.004. Epub 2013 Jan 15.

PMID:
23333567
5.

Spinal D-Serine Increases PKC-Dependent GluN1 Phosphorylation Contributing to the Sigma-1 Receptor-Induced Development of Mechanical Allodynia in a Mouse Model of Neuropathic Pain.

Choi SR, Moon JY, Roh DH, Yoon SY, Kwon SG, Choi HS, Kang SY, Han HJ, Beitz AJ, Lee JH.

J Pain. 2017 Apr;18(4):415-427. doi: 10.1016/j.jpain.2016.12.002. Epub 2016 Dec 14.

PMID:
27986591
6.

Spinal sigma-1 receptor activation increases the production of D-serine in astrocytes which contributes to the development of mechanical allodynia in a mouse model of neuropathic pain.

Moon JY, Choi SR, Roh DH, Yoon SY, Kwon SG, Choi HS, Kang SY, Han HJ, Kim HW, Beitz AJ, Oh SB, Lee JH.

Pharmacol Res. 2015 Oct;100:353-64. doi: 10.1016/j.phrs.2015.08.019. Epub 2015 Aug 24.

PMID:
26316425
7.

Astrocyte sigma-1 receptors modulate connexin 43 expression leading to the induction of below-level mechanical allodynia in spinal cord injured mice.

Choi SR, Roh DH, Yoon SY, Kwon SG, Choi HS, Han HJ, Beitz AJ, Lee JH.

Neuropharmacology. 2016 Dec;111:34-46. doi: 10.1016/j.neuropharm.2016.08.027. Epub 2016 Aug 24.

PMID:
27567941
8.

NADPH oxidase 2-derived reactive oxygen species in spinal cord microglia contribute to peripheral nerve injury-induced neuropathic pain.

Kim D, You B, Jo EK, Han SK, Simon MI, Lee SJ.

Proc Natl Acad Sci U S A. 2010 Aug 17;107(33):14851-6. doi: 10.1073/pnas.1009926107. Epub 2010 Aug 2.

9.

The spinal antinociceptive mechanism determined by systemic administration of BD1047 in zymosan-induced hyperalgesia in rats.

Jeong YC, Son JS, Kwon YB.

Brain Res Bull. 2015 Oct;119(Pt A):93-100. doi: 10.1016/j.brainresbull.2015.07.006. Epub 2015 Oct 1.

PMID:
26434709
10.

Nox2-dependent signaling between macrophages and sensory neurons contributes to neuropathic pain hypersensitivity.

Kallenborn-Gerhardt W, Hohmann SW, Syhr KM, Schröder K, Sisignano M, Weigert A, Lorenz JE, Lu R, Brüne B, Brandes RP, Geisslinger G, Schmidtko A.

Pain. 2014 Oct;155(10):2161-70. doi: 10.1016/j.pain.2014.08.013. Epub 2014 Aug 17.

PMID:
25139590
11.

Possible involvement of the Sigma-1 receptor chaperone in chemotherapeutic-induced neuropathic pain.

Tomohisa M, Junpei O, Aki M, Masato H, Mika F, Kazumi Y, Teruo H, Tsutomu S.

Synapse. 2015 Nov;69(11):526-32. doi: 10.1002/syn.21844. Epub 2015 Sep 8.

PMID:
26234785
12.

Activation of the spinal sigma-1 receptor enhances NMDA-induced pain via PKC- and PKA-dependent phosphorylation of the NR1 subunit in mice.

Kim HW, Roh DH, Yoon SY, Seo HS, Kwon YB, Han HJ, Kim KW, Beitz AJ, Lee JH.

Br J Pharmacol. 2008 Jul;154(5):1125-34. doi: 10.1038/bjp.2008.159. Epub 2008 May 19.

13.
14.

Spinal neuronal NOS activation mediates sigma-1 receptor-induced mechanical and thermal hypersensitivity in mice: involvement of PKC-dependent GluN1 phosphorylation.

Roh DH, Choi SR, Yoon SY, Kang SY, Moon JY, Kwon SG, Han HJ, Beitz AJ, Lee JH.

Br J Pharmacol. 2011 Aug;163(8):1707-20. doi: 10.1111/j.1476-5381.2011.01316.x.

15.

Intrathecal clonidine suppresses phosphorylation of the N-methyl-D-aspartate receptor NR1 subunit in spinal dorsal horn neurons of rats with neuropathic pain.

Roh DH, Kim HW, Yoon SY, Seo HS, Kwon YB, Han HJ, Beitz AJ, Lee JH.

Anesth Analg. 2008 Aug;107(2):693-700. doi: 10.1213/ane.0b013e31817e7319.

PMID:
18633054
16.

Intrathecal injection of carbenoxolone, a gap junction decoupler, attenuates the induction of below-level neuropathic pain after spinal cord injury in rats.

Roh DH, Yoon SY, Seo HS, Kang SY, Han HJ, Beitz AJ, Lee JH.

Exp Neurol. 2010 Jul;224(1):123-32. doi: 10.1016/j.expneurol.2010.03.002. Epub 2010 Mar 11.

PMID:
20226782
17.

Activation of extracellular signal-regulated protein kinases 5 in the spinal cord contributes to the neuropathic pain behaviors induced by CCI in rats.

Zhang L, Xiao C, Wang JK, Zhang LC, Zeng YM.

Neurol Res. 2009 Dec;31(10):1037-43. doi: 10.1179/174313209X405128. Epub 2009 May 8.

PMID:
19426589
19.

Spinal P2X(7) receptor mediates microglia activation-induced neuropathic pain in the sciatic nerve injury rat model.

He WJ, Cui J, Du L, Zhao YD, Burnstock G, Zhou HD, Ruan HZ.

Behav Brain Res. 2012 Jan 1;226(1):163-70. doi: 10.1016/j.bbr.2011.09.015. Epub 2011 Sep 14.

PMID:
21933684
20.

σ1 receptors activate astrocytes via p38 MAPK phosphorylation leading to the development of mechanical allodynia in a mouse model of neuropathic pain.

Moon JY, Roh DH, Yoon SY, Choi SR, Kwon SG, Choi HS, Kang SY, Han HJ, Beitz AJ, Oh SB, Lee JH.

Br J Pharmacol. 2014 Dec;171(24):5881-97. doi: 10.1111/bph.12893. Epub 2014 Nov 24.

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