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Items: 1 to 20 of 93

1.
2.

Pyruvate Dehydrogenase Kinases: Therapeutic Targets for Diabetes and Cancers.

Jeoung NH.

Diabetes Metab J. 2015 Jun;39(3):188-97. doi: 10.4093/dmj.2015.39.3.188. Review.

3.

Metabolic reprogramming by the pyruvate dehydrogenase kinase-lactic acid axis: Linking metabolism and diverse neuropathophysiologies.

Jha MK, Lee IK, Suk K.

Neurosci Biobehav Rev. 2016 Sep;68:1-19. doi: 10.1016/j.neubiorev.2016.05.006. Epub 2016 May 11. Review.

PMID:
27179453
4.

Targeting Tumor Metabolism for Cancer Treatment: Is Pyruvate Dehydrogenase Kinases (PDKs) a Viable Anticancer Target?

Zhang W, Zhang SL, Hu X, Tam KY.

Int J Biol Sci. 2015 Nov 1;11(12):1390-400. doi: 10.7150/ijbs.13325. eCollection 2015. Review.

5.

Recent advances in mechanisms regulating glucose oxidation at the level of the pyruvate dehydrogenase complex by PDKs.

Sugden MC, Holness MJ.

Am J Physiol Endocrinol Metab. 2003 May;284(5):E855-62. Review.

6.

The pyruvate dehydrogenase complex in cancer: An old metabolic gatekeeper regulated by new pathways and pharmacological agents.

Saunier E, Benelli C, Bortoli S.

Int J Cancer. 2016 Feb 15;138(4):809-17. doi: 10.1002/ijc.29564. Epub 2015 Apr 28. Review.

7.

Metabolic Connection of Inflammatory Pain: Pivotal Role of a Pyruvate Dehydrogenase Kinase-Pyruvate Dehydrogenase-Lactic Acid Axis.

Jha MK, Song GJ, Lee MG, Jeoung NH, Go Y, Harris RA, Park DH, Kook H, Lee IK, Suk K.

J Neurosci. 2015 Oct 21;35(42):14353-69. doi: 10.1523/JNEUROSCI.1910-15.2015.

9.

Regulation of pyruvate dehydrogenase complex activity by reversible phosphorylation.

Holness MJ, Sugden MC.

Biochem Soc Trans. 2003 Dec;31(Pt 6):1143-51. Review.

PMID:
14641014
10.

Distinct regulatory properties of pyruvate dehydrogenase kinase and phosphatase isoforms.

Roche TE, Baker JC, Yan X, Hiromasa Y, Gong X, Peng T, Dong J, Turkan A, Kasten SA.

Prog Nucleic Acid Res Mol Biol. 2001;70:33-75. Review.

PMID:
11642366
11.

R-lipoic acid inhibits mammalian pyruvate dehydrogenase kinase.

Korotchkina LG, Sidhu S, Patel MS.

Free Radic Res. 2004 Oct;38(10):1083-92.

PMID:
15512796
12.

The pivotal role of pyruvate dehydrogenase kinases in metabolic flexibility.

Zhang S, Hulver MW, McMillan RP, Cline MA, Gilbert ER.

Nutr Metab (Lond). 2014 Feb 12;11(1):10. doi: 10.1186/1743-7075-11-10.

13.

Computational Study on New Natural Compound Inhibitors of Pyruvate Dehydrogenase Kinases.

Zhou X, Yu S, Su J, Sun L.

Int J Mol Sci. 2016 Mar 4;17(3):340. doi: 10.3390/ijms17030340.

14.

Therapeutic potential of the mammalian pyruvate dehydrogenase kinases in the prevention of hyperglycaemia.

Sugden MC, Holness MJ.

Curr Drug Targets Immune Endocr Metabol Disord. 2002 Jul;2(2):151-65. Review.

PMID:
12476789
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17.

Reciprocal control of pyruvate dehydrogenase kinase and phosphatase by inositol phosphoglycans. Dynamic state set by "push-pull" system.

McLean P, Kunjara S, Greenbaum AL, Gumaa K, López-Prados J, Martin-Lomas M, Rademacher TW.

J Biol Chem. 2008 Nov 28;283(48):33428-36. doi: 10.1074/jbc.M801781200. Epub 2008 Sep 3.

18.

Phosphorylation status of pyruvate dehydrogenase distinguishes metabolic phenotypes of cultured rat brain astrocytes and neurons.

Halim ND, Mcfate T, Mohyeldin A, Okagaki P, Korotchkina LG, Patel MS, Jeoung NH, Harris RA, Schell MJ, Verma A.

Glia. 2010 Aug;58(10):1168-76. doi: 10.1002/glia.20996.

19.

Pyruvate dehydrogenase kinase 2 and 4 gene deficiency attenuates nociceptive behaviors in a mouse model of acute inflammatory pain.

Jha MK, Rahman MH, Park DH, Kook H, Lee IK, Lee WH, Suk K.

J Neurosci Res. 2016 Sep;94(9):837-49. doi: 10.1002/jnr.23727. Epub 2016 Mar 1.

PMID:
26931482
20.

Pyruvate dehydrogenase complex activity controls metabolic and malignant phenotype in cancer cells.

McFate T, Mohyeldin A, Lu H, Thakar J, Henriques J, Halim ND, Wu H, Schell MJ, Tsang TM, Teahan O, Zhou S, Califano JA, Jeoung NH, Harris RA, Verma A.

J Biol Chem. 2008 Aug 15;283(33):22700-8. doi: 10.1074/jbc.M801765200. Epub 2008 Jun 9.

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