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Pinocembrin protects rats against cerebral ischemic damage through soluble epoxide hydrolase and epoxyeicosatrienoic acids.

Wang SB, Pang XB, Gao M, Fang LH, Du GH.

Chin J Nat Med. 2013 May;11(3):207-13. doi: 10.1016/S1875-5364(13)60018-7.


Protection of salvianolic acid A on rat brain from ischemic damage via soluble epoxide hydrolase inhibition.

Wang SB, Pang XB, Zhao Y, Wang YH, Zhang L, Yang XY, Fang LH, Du GH.

J Asian Nat Prod Res. 2012;14(11):1084-92. doi: 10.1080/10286020.2012.723200. Epub 2012 Oct 29.


Soluble epoxide hydrolase gene deletion is protective against experimental cerebral ischemia.

Zhang W, Otsuka T, Sugo N, Ardeshiri A, Alhadid YK, Iliff JJ, DeBarber AE, Koop DR, Alkayed NJ.

Stroke. 2008 Jul;39(7):2073-8. doi: 10.1161/STROKEAHA.107.508325. Epub 2008 Mar 27.


Pinocembrin protects brain against ischemia/reperfusion injury by attenuating endoplasmic reticulum stress induced apoptosis.

Wu CX, Liu R, Gao M, Zhao G, Wu S, Wu CF, Du GH.

Neurosci Lett. 2013 Jun 24;546:57-62. doi: 10.1016/j.neulet.2013.04.060. Epub 2013 May 10.


Polymorphisms in the human soluble epoxide hydrolase gene EPHX2 linked to neuronal survival after ischemic injury.

Koerner IP, Jacks R, DeBarber AE, Koop D, Mao P, Grant DF, Alkayed NJ.

J Neurosci. 2007 Apr 25;27(17):4642-9.


Distribution of soluble and microsomal epoxide hydrolase in the mouse brain and its contribution to cerebral epoxyeicosatrienoic acid metabolism.

Marowsky A, Burgener J, Falck JR, Fritschy JM, Arand M.

Neuroscience. 2009 Oct 6;163(2):646-61. doi: 10.1016/j.neuroscience.2009.06.033. Epub 2009 Jun 18.


Role of soluble epoxide hydrolase in the sex-specific vascular response to cerebral ischemia.

Zhang W, Iliff JJ, Campbell CJ, Wang RK, Hurn PD, Alkayed NJ.

J Cereb Blood Flow Metab. 2009 Aug;29(8):1475-81. doi: 10.1038/jcbfm.2009.65. Epub 2009 May 27.


Soluble epoxide hydrolase inhibition and gene deletion are protective against myocardial ischemia-reperfusion injury in vivo.

Motoki A, Merkel MJ, Packwood WH, Cao Z, Liu L, Iliff J, Alkayed NJ, Van Winkle DM.

Am J Physiol Heart Circ Physiol. 2008 Nov;295(5):H2128-34. doi: 10.1152/ajpheart.00428.2008. Epub 2008 Oct 3.


Pinocembrin protects the brain against ischemia-reperfusion injury and reverses the autophagy dysfunction in the penumbra area.

Zhao G, Zhang W, Li L, Wu S, Du G.

Molecules. 2014 Sep 30;19(10):15786-98. doi: 10.3390/molecules191015786.


Soluble epoxide hydrolase inhibitor trans-4-[4-(3-adamantan-1-yl-ureido)-cyclohexyloxy]-benzoic acid is neuroprotective in rat model of ischemic stroke.

Shaik JS, Ahmad M, Li W, Rose ME, Foley LM, Hitchens TK, Graham SH, Hwang SH, Hammock BD, Poloyac SM.

Am J Physiol Heart Circ Physiol. 2013 Dec 1;305(11):H1605-13. doi: 10.1152/ajpheart.00471.2013. Epub 2013 Sep 16.


Soluble epoxide hydrolase: a novel therapeutic target in stroke.

Zhang W, Koerner IP, Noppens R, Grafe M, Tsai HJ, Morisseau C, Luria A, Hammock BD, Falck JR, Alkayed NJ.

J Cereb Blood Flow Metab. 2007 Dec;27(12):1931-40. Epub 2007 Apr 18.


Soluble epoxide hydrolase: regulation by estrogen and role in the inflammatory response to cerebral ischemia.

Koerner IP, Zhang W, Cheng J, Parker S, Hurn PD, Alkayed NJ.

Front Biosci. 2008 Jan 1;13:2833-41.


Soluble epoxide inhibition is protective against cerebral ischemia via vascular and neural protection.

Simpkins AN, Rudic RD, Schreihofer DA, Roy S, Manhiani M, Tsai HJ, Hammock BD, Imig JD.

Am J Pathol. 2009 Jun;174(6):2086-95. doi: 10.2353/ajpath.2009.080544. Epub 2009 May 12.


Inhibition of soluble epoxide hydrolase preserves cardiomyocytes: role of STAT3 signaling.

Merkel MJ, Liu L, Cao Z, Packwood W, Young J, Alkayed NJ, Van Winkle DM.

Am J Physiol Heart Circ Physiol. 2010 Feb;298(2):H679-87. doi: 10.1152/ajpheart.00533.2009. Epub 2009 Dec 11.


Acute neurovascular unit protective action of pinocembrin against permanent cerebral ischemia in rats.

Gao M, Liu R, Zhu SY, Du GH.

J Asian Nat Prod Res. 2008 May-Jun;10(5-6):551-8. doi: 10.1080/10286020801966955.


Role of endothelial soluble epoxide hydrolase in cerebrovascular function and ischemic injury.

Zhang W, Davis CM, Edin ML, Lee CR, Zeldin DC, Alkayed NJ.

PLoS One. 2013 Apr 9;8(4):e61244. doi: 10.1371/journal.pone.0061244. Print 2013.


Novel mechanism of brain soluble epoxide hydrolase-mediated blood pressure regulation in the spontaneously hypertensive rat.

Sellers KW, Sun C, Diez-Freire C, Waki H, Morisseau C, Falck JR, Hammock BD, Paton JF, Raizada MK.

FASEB J. 2005 Apr;19(6):626-8. Epub 2005 Jan 19.


Epoxyeicosatrienoic acids limit damage to mitochondrial function following stress in cardiac cells.

Katragadda D, Batchu SN, Cho WJ, Chaudhary KR, Falck JR, Seubert JM.

J Mol Cell Cardiol. 2009 Jun;46(6):867-75. doi: 10.1016/j.yjmcc.2009.02.028. Epub 2009 Mar 12.


Distribution and expression of soluble epoxide hydrolase in human brain.

Sura P, Sura R, Enayetallah AE, Grant DF.

J Histochem Cytochem. 2008 Jun;56(6):551-9. doi: 10.1369/jhc.2008.950659. Epub 2008 Mar 3.


Mechanism of protection by soluble epoxide hydrolase inhibition in type 2 diabetic stroke.

Zuloaga KL, Krasnow SM, Zhu X, Zhang W, Jouihan SA, Shangraw RE, Alkayed NJ, Marks DL.

PLoS One. 2014 May 13;9(5):e97529. doi: 10.1371/journal.pone.0097529. eCollection 2014.

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