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Items: 1 to 20 of 101

1.

Dual-functional abeo-taxane derivatives destabilizing microtubule equilibrium and inhibiting NF-κB activation.

Zhao Y, Su J, Goto M, Morris-Natschke SL, Li Y, Zhao QS, Yao ZJ, Lee KH.

J Med Chem. 2013 Jun 13;56(11):4749-57. doi: 10.1021/jm400479p. Epub 2013 May 31.

2.

Synthesis, cytotoxic activity, and SAR analysis of the derivatives of taxchinin A and brevifoliol.

Zhao Y, Guo N, Lou LG, Cong YW, Peng LY, Zhao QS.

Bioorg Med Chem. 2008 May 1;16(9):4860-71. doi: 10.1016/j.bmc.2008.03.041. Epub 2008 Mar 20.

PMID:
18381240
3.

(Z)-1-aryl-3-arylamino-2-propen-1-ones, highly active stimulators of tubulin polymerization: synthesis, structure-activity relationship (SAR), tubulin polymerization, and cell growth inhibition studies.

Reddy MV, Akula B, Cosenza SC, Lee CM, Mallireddigari MR, Pallela VR, Subbaiah DR, Udofa A, Reddy EP.

J Med Chem. 2012 Jun 14;55(11):5174-87. doi: 10.1021/jm300176j. Epub 2012 May 25.

4.

Synthesis, cytotoxic properties and tubulin polymerization inhibitory activity of novel 2-pyrazoline derivatives.

Abdel-Aziz M, Aly OM, Khan SS, Mukherjee K, Bane S.

Arch Pharm (Weinheim). 2012 Jul;345(7):535-48. doi: 10.1002/ardp.201100471. Epub 2012 May 16.

PMID:
22592968
5.

Design, synthesis and antiproliferative activity of the new conjugates of E7010 and resveratrol as tubulin polymerization inhibitors.

Kamal A, Ashraf M, Basha ST, Ali Hussaini SM, Singh S, Vishnuvardhan MV, Kiran B, Sridhar B.

Org Biomol Chem. 2016 Jan 28;14(4):1382-94. doi: 10.1039/c5ob02022k. Epub 2015 Dec 16.

PMID:
26676480
6.

A semisynthetic taxane Yg-3-46a effectively evades P-glycoprotein and β-III tubulin mediated tumor drug resistance in vitro.

Cai P, Lu P, Sharom FJ, Fang WS.

Cancer Lett. 2013 Dec 1;341(2):214-23. doi: 10.1016/j.canlet.2013.08.010. Epub 2013 Aug 11.

PMID:
23941826
7.

Design, synthesis and biological evaluation of novel pyrazoline-containing derivatives as potential tubulin assembling inhibitors.

Qin YJ, Li YJ, Jiang AQ, Yang MR, Zhu QZ, Dong H, Zhu HL.

Eur J Med Chem. 2015 Apr 13;94:447-57. doi: 10.1016/j.ejmech.2015.02.058. Epub 2015 Mar 3.

PMID:
25828827
8.

2-amino and 2'-aminocombretastatin derivatives as potent antimitotic agents.

Chang JY, Yang MF, Chang CY, Chen CM, Kuo CC, Liou JP.

J Med Chem. 2006 Oct 19;49(21):6412-5.

PMID:
17034147
9.

Syntheses and biological evaluation of C-3'-N-acyl modified taxane analogues from 1-deoxybaccatin-VI.

Li QF, Lin HX, Cui YM, Xu PP.

Eur J Med Chem. 2015 Nov 2;104:97-105. doi: 10.1016/j.ejmech.2015.09.019. Epub 2015 Sep 28.

PMID:
26448037
10.

Synthesis, biological activity and tubulin binding poses of 1-deoxy-9-(R)-dihydrotaxane analogs.

Yuan TH, Jiang Y, Wang XH, Wang DL, Bannerjee A, Bane S, Snyder JP, Lin HX.

Bioorg Med Chem Lett. 2009 Feb 15;19(4):1148-51. doi: 10.1016/j.bmcl.2008.12.091. Epub 2008 Dec 27.

PMID:
19136258
11.

Synthesis of aryl dihydrothiazol acyl shikonin ester derivatives as anticancer agents through microtubule stabilization.

Lin HY, Li ZK, Bai LF, Baloch SK, Wang F, Qiu HY, Wang X, Qi JL, Yang RW, Wang XM, Yang YH.

Biochem Pharmacol. 2015 Jul 15;96(2):93-106. doi: 10.1016/j.bcp.2015.04.021. Epub 2015 May 6.

PMID:
25957661
12.

Synthesis of a terphenyl substituted 4-aza-2,3-didehydropodophyllotoxin analogues as inhibitors of tubulin polymerization and apoptosis inducers.

Kamal A, Tamboli JR, Nayak VL, Adil SF, Vishnuvardhan MV, Ramakrishna S.

Bioorg Med Chem. 2014 May 1;22(9):2714-23. doi: 10.1016/j.bmc.2014.03.021. Epub 2014 Mar 22.

PMID:
24721832
13.

Synthesis, biological evaluation, and molecular modeling of cinnamic acyl sulfonamide derivatives as novel antitubulin agents.

Luo Y, Qiu KM, Lu X, Liu K, Fu J, Zhu HL.

Bioorg Med Chem. 2011 Aug 15;19(16):4730-8. doi: 10.1016/j.bmc.2011.06.088. Epub 2011 Jul 7.

PMID:
21783370
14.

Discovery of potent cytotoxic ortho-aryl chalcones as new scaffold targeting tubulin and mitosis with affinity-based fluorescence.

Zhu C, Zuo Y, Wang R, Liang B, Yue X, Wen G, Shang N, Huang L, Chen Y, Du J, Bu X.

J Med Chem. 2014 Aug 14;57(15):6364-82. doi: 10.1021/jm500024v. Epub 2014 Jul 25.

PMID:
25061803
15.

Preclinical pharmacologic evaluation of MST-997, an orally active taxane with superior in vitro and in vivo efficacy in paclitaxel- and docetaxel-resistant tumor models.

Sampath D, Greenberger LM, Beyer C, Hari M, Liu H, Baxter M, Yang S, Rios C, Discafani C.

Clin Cancer Res. 2006 Jun 1;12(11 Pt 1):3459-69.

16.

Synthesis and biological evaluation of 1-phenyl-1,2,3,4-dihydroisoquinoline compounds as tubulin polymerization inhibitors.

Zheng CH, Chen J, Liu J, Zhou XT, Liu N, Shi D, Huang JJ, Lv JG, Zhu J, Zhou YJ.

Arch Pharm (Weinheim). 2012 Jun;345(6):454-62. doi: 10.1002/ardp.201100169. Epub 2012 Mar 13.

PMID:
22415658
17.

Synthesis and antiproliferative activity of novel 2-aryl-4-benzoyl-imidazole derivatives targeting tubulin polymerization.

Chen J, Li CM, Wang J, Ahn S, Wang Z, Lu Y, Dalton JT, Miller DD, Li W.

Bioorg Med Chem. 2011 Aug 15;19(16):4782-95. doi: 10.1016/j.bmc.2011.06.084. Epub 2011 Jul 1.

18.

Relationship between the structures of taxane derivatives and their microtubule polymerization activity.

Hidaka M, Koga T, Kiyota H, Horiguchi T, Shi QW, Hirose K, Uchida T.

Biosci Biotechnol Biochem. 2012;76(2):349-52. Epub 2012 Feb 7.

19.

Synthesis of macrocyclic bisbibenzyl derivatives and their anticancer effects as anti-tubulin agents.

Jiang J, Sun B, Wang YY, Cui M, Zhang L, Cui CZ, Wang YF, Liu XG, Lou HX.

Bioorg Med Chem. 2012 Apr 1;20(7):2382-91. doi: 10.1016/j.bmc.2012.02.004. Epub 2012 Feb 9.

PMID:
22365913
20.

New pyrrole derivatives with potent tubulin polymerization inhibiting activity as anticancer agents including hedgehog-dependent cancer.

La Regina G, Bai R, Coluccia A, Famiglini V, Pelliccia S, Passacantilli S, Mazzoccoli C, Ruggieri V, Sisinni L, Bolognesi A, Rensen WM, Miele A, Nalli M, Alfonsi R, Di Marcotullio L, Gulino A, Brancale A, Novellino E, Dondio G, Vultaggio S, Varasi M, Mercurio C, Hamel E, Lavia P, Silvestri R.

J Med Chem. 2014 Aug 14;57(15):6531-52. doi: 10.1021/jm500561a. Epub 2014 Jul 29.

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