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Items: 1 to 20 of 105

1.

Development of a Medium-term Animal Model Using gpt Delta Rats to Evaluate Chemical Carcinogenicity and Genotoxicity.

Matsushita K, Kijima A, Ishii Y, Takasu S, Jin M, Kuroda K, Kawaguchi H, Miyoshi N, Nohmi T, Ogawa K, Umemura T.

J Toxicol Pathol. 2013 Mar;26(1):19-27. doi: 10.1293/tox.26.19. Epub 2013 Apr 22.

2.

Improvement and validation of a medium-term gpt delta rat model for predicting chemical carcinogenicity and underlying mode of action.

Matsushita K, Kuroda K, Ishii Y, Takasu S, Kijima A, Kawaguchi H, Miyoshi N, Nohmi T, Ogawa K, Nishikawa A, Umemura T.

Exp Toxicol Pathol. 2014 Sep;66(7):313-21. doi: 10.1016/j.etp.2014.05.002. Epub 2014 Jun 11.

PMID:
24929978
3.

A medium-term gpt delta rat model as an in vivo system for analysis of renal carcinogenesis and the underlying mode of action.

Matsushita K, Ishii Y, Takasu S, Kuroda K, Kijima A, Tsuchiya T, Kawaguchi H, Miyoshi N, Nohmi T, Ogawa K, Nishikawa A, Umemura T.

Exp Toxicol Pathol. 2015 Jan;67(1):31-9. doi: 10.1016/j.etp.2014.09.006. Epub 2014 Oct 16.

PMID:
25446801
4.

Validation study of the combined repeated-dose toxicity and genotoxicity assay using gpt delta rats.

Akagi J, Toyoda T, Cho YM, Mizuta Y, Nohmi T, Nishikawa A, Ogawa K.

Cancer Sci. 2015 May;106(5):529-41. doi: 10.1111/cas.12634. Epub 2015 Apr 10.

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Oxidative DNA damage and reporter gene mutation in the livers of gpt delta rats given non-genotoxic hepatocarcinogens with cytochrome P450-inducible potency.

Tasaki M, Umemura T, Suzuki Y, Hibi D, Inoue T, Okamura T, Ishii Y, Maruyama S, Nohmi T, Nishikawa A.

Cancer Sci. 2010 Dec;101(12):2525-30. doi: 10.1111/j.1349-7006.2010.01705.x.

9.

Comprehensive toxicity study of safrole using a medium-term animal model with gpt delta rats.

Jin M, Kijima A, Suzuki Y, Hibi D, Inoue T, Ishii Y, Nohmi T, Nishikawa A, Ogawa K, Umemura T.

Toxicology. 2011 Dec 18;290(2-3):312-21. doi: 10.1016/j.tox.2011.09.088. Epub 2011 Oct 15.

PMID:
22024337
10.
11.

Suppressive effect of liver tumor-promoting activities in rats subjected to combined administration of phenobarbital and piperonyl butoxide.

Morita R, Yafune A, Shiraki A, Itahashi M, Akane H, Nakane F, Suzuki K, Shibutani M, Mitsumori K.

J Toxicol Sci. 2013;38(5):679-88.

12.

Kojic acid -absence of tumor-initiating activity in rat liver, and of carcinogenic and photo-genotoxic potential in mouse skin.

Higa Y, Kawabe M, Nabae K, Toda Y, Kitamoto S, Hara T, Tanaka N, Kariya K, Takahashi M.

J Toxicol Sci. 2007 May;32(2):143-59.

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Integration of in vivo genotoxicity and short-term carcinogenicity assays using F344 gpt delta transgenic rats: in vivo mutagenicity of 2,4-diaminotoluene and 2,6-diaminotoluene structural isomers.

Toyoda-Hokaiwado N, Inoue T, Masumura K, Hayashi H, Kawamura Y, Kurata Y, Takamune M, Yamada M, Sanada H, Umemura T, Nishikawa A, Nohmi T.

Toxicol Sci. 2010 Mar;114(1):71-8. doi: 10.1093/toxsci/kfp306. Epub 2009 Dec 21.

17.

Dose-dependent effects of 2-acetylaminofluorene on hepatic foci development and cell proliferation in rats.

Tiwawech D, Hasegawa R, Kurata Y, Tatematsu M, Shibata MA, Thamavit W, Ito N.

Carcinogenesis. 1991 Jun;12(6):985-90.

PMID:
2044205
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Medium-term bioassays as alternative carcinogenicity test.

Ito N, Imaida K, Tamano S, Hagiwara A, Shirai T.

J Toxicol Sci. 1998 Jul;23 Suppl 2:103-6.

PMID:
9760442

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