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Loss of SS18-SSX1 inhibits viability and induces apoptosis in synovial sarcoma.

Carmody Soni EE, Schlottman S, Erkizan HV, Uren A, Toretsky JA.

Clin Orthop Relat Res. 2014 Mar;472(3):874-82. doi: 10.1007/s11999-013-3065-9.


Detection of SS18-SSX fusion transcripts in formalin-fixed paraffin-embedded neoplasms: analysis of conventional RT-PCR, qRT-PCR and dual color FISH as diagnostic tools for synovial sarcoma.

Amary MF, Berisha F, Bernardi Fdel C, Herbert A, James M, Reis-Filho JS, Fisher C, Nicholson AG, Tirabosco R, Diss TC, Flanagan AM.

Mod Pathol. 2007 Apr;20(4):482-96. Epub 2007 Mar 2.


The clinical implication of SS18-SSX fusion gene in synovial sarcoma.

Ren T, Lu Q, Guo W, Lou Z, Peng X, Jiao G, Sun Y.

Br J Cancer. 2013 Oct 15;109(8):2279-85. doi: 10.1038/bjc.2013.547. Epub 2013 Sep 10.


A novel fusion gene, SS18L1/SSX1, in synovial sarcoma.

Storlazzi CT, Mertens F, Mandahl N, Gisselsson D, Isaksson M, Gustafson P, Domanski HA, Panagopoulos I.

Genes Chromosomes Cancer. 2003 Jun;37(2):195-200.


Downregulation of SS18-SSX1 expression by small interfering RNA inhibits growth and induces apoptosis in human synovial sarcoma cell line HS-SY-II in vitro.

Peng C, Guo W, Yang Y, Zhao H.

Eur J Cancer Prev. 2008 Oct;17(5):392-8. doi: 10.1097/CEJ.0b013e328305a11b.


A novel FISH assay for SS18-SSX fusion type in synovial sarcoma.

Surace C, Panagopoulos I, Pålsson E, Rocchi M, Mandahl N, Mertens F.

Lab Invest. 2004 Sep;84(9):1185-92.


The impact of chromosomal translocation locus and fusion oncogene coding sequence in synovial sarcomagenesis.

Jones KB, Barrott JJ, Xie M, Haldar M, Jin H, Zhu JF, Monument MJ, Mosbruger TL, Langer EM, Randall RL, Wilson RK, Cairns BR, Ding L, Capecchi MR.

Oncogene. 2016 Sep 22;35(38):5021-32. doi: 10.1038/onc.2016.38. Epub 2016 Mar 7.


BCOR upregulation in a poorly differentiated synovial sarcoma with SS18L1-SSX1 fusion-A pathologic and molecular pitfall.

Kao YC, Sung YS, Zhang L, Kenan S, Singer S, Tap WD, Swanson D, Dickson BC, Antonescu CR.

Genes Chromosomes Cancer. 2017 Apr;56(4):296-302. doi: 10.1002/gcc.22435. Epub 2017 Jan 4.


SS18-SSX fusion protein-induced Wnt/β-catenin signaling is a therapeutic target in synovial sarcoma.

Trautmann M, Sievers E, Aretz S, Kindler D, Michels S, Friedrichs N, Renner M, Kirfel J, Steiner S, Huss S, Koch A, Penzel R, Larsson O, Kawai A, Tanaka S, Sonobe H, Waha A, Schirmacher P, Mechtersheimer G, Wardelmann E, Büttner R, Hartmann W.

Oncogene. 2014 Oct 16;33(42):5006-16. doi: 10.1038/onc.2013.443. Epub 2013 Oct 28.


Identification of SHCBP1 as a novel downstream target gene of SS18-SSX1 and its functional analysis in progression of synovial sarcoma.

Peng C, Zhao H, Chen W, Song Y, Wang X, Li J, Qiao Y, Wu D, Ma S, Wang X, Gao C.

Oncotarget. 2016 Oct 11;7(41):66822-66834. doi: 10.18632/oncotarget.11651.


Truncated SSX protein suppresses synovial sarcoma cell proliferation by inhibiting the localization of SS18-SSX fusion protein.

Yoneda Y, Ito S, Kunisada T, Morimoto Y, Kanzaki H, Yoshida A, Shimizu K, Ozaki T, Ouchida M.

PLoS One. 2013 Oct 9;8(10):e77564. doi: 10.1371/journal.pone.0077564. eCollection 2013.


SYT-SSX gene fusion as a determinant of morphology and prognosis in synovial sarcoma.

Kawai A, Woodruff J, Healey JH, Brennan MF, Antonescu CR, Ladanyi M.

N Engl J Med. 1998 Jan 15;338(3):153-60.


The SYT-SSX fusion protein down-regulates the cell proliferation regulator COM1 in t(x;18) synovial sarcoma.

Ishida M, Miyamoto M, Naitoh S, Tatsuda D, Hasegawa T, Nemoto T, Yokozeki H, Nishioka K, Matsukage A, Ohki M, Ohta T.

Mol Cell Biol. 2007 Feb;27(4):1348-55. Epub 2006 Nov 13.


Recurrent and novel SS18-SSX fusion transcripts in synovial sarcoma: description of three new cases.

Przybyl J, Sciot R, Rutkowski P, Siedlecki JA, Vanspauwen V, Samson I, Debiec-Rychter M.

Tumour Biol. 2012 Dec;33(6):2245-53. doi: 10.1007/s13277-012-0486-0. Epub 2012 Sep 14.


Reversible disruption of mSWI/SNF (BAF) complexes by the SS18-SSX oncogenic fusion in synovial sarcoma.

Kadoch C, Crabtree GR.

Cell. 2013 Mar 28;153(1):71-85. doi: 10.1016/j.cell.2013.02.036.


Differential roles of SS18-SSX fusion gene and insulin-like growth factor-1 receptor in synovial sarcoma cell growth.

Törnkvist M, Natalishvili N, Xie Y, Girnita A, D'Arcy P, Brodin B, Axelson M, Girnita L.

Biochem Biophys Res Commun. 2008 Apr 11;368(3):793-800. doi: 10.1016/j.bbrc.2008.01.162. Epub 2008 Feb 11.


Deconstruction of the SS18-SSX fusion oncoprotein complex: insights into disease etiology and therapeutics.

Su L, Sampaio AV, Jones KB, Pacheco M, Goytain A, Lin S, Poulin N, Yi L, Rossi FM, Kast J, Capecchi MR, Underhill TM, Nielsen TO.

Cancer Cell. 2012 Mar 20;21(3):333-47. doi: 10.1016/j.ccr.2012.01.010.


The oncoprotein SS18-SSX1 promotes p53 ubiquitination and degradation by enhancing HDM2 stability.

D'Arcy P, Maruwge W, Ryan BA, Brodin B.

Mol Cancer Res. 2008 Jan;6(1):127-38. doi: 10.1158/1541-7786.MCR-07-0176.

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