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Items: 1 to 20 of 108

1.

Bulky "gatekeeper" residue changes the cosubstrate specificity of aminoglycoside 2''-phosphotransferase IIa.

Bhattacharya M, Toth M, Smith CA, Vakulenko SB.

Antimicrob Agents Chemother. 2013 Aug;57(8):3763-6. doi: 10.1128/AAC.00381-13. Epub 2013 May 28.

2.

Aminoglycoside 2''-phosphotransferase IIIa (APH(2'')-IIIa) prefers GTP over ATP: structural templates for nucleotide recognition in the bacterial aminoglycoside-2'' kinases.

Smith CA, Toth M, Frase H, Byrnes LJ, Vakulenko SB.

J Biol Chem. 2012 Apr 13;287(16):12893-903. doi: 10.1074/jbc.M112.341206. Epub 2012 Feb 24.

3.
4.
5.

Novel aminoglycoside 2''-phosphotransferase identified in a gram-negative pathogen.

Toth M, Frase H, Antunes NT, Vakulenko SB.

Antimicrob Agents Chemother. 2013 Jan;57(1):452-7. doi: 10.1128/AAC.02049-12. Epub 2012 Nov 5.

6.

Crystal structure and kinetic mechanism of aminoglycoside phosphotransferase-2''-IVa.

Toth M, Frase H, Antunes NT, Smith CA, Vakulenko SB.

Protein Sci. 2010 Aug;19(8):1565-76. doi: 10.1002/pro.437.

7.

Structure of the phosphotransferase domain of the bifunctional aminoglycoside-resistance enzyme AAC(6')-Ie-APH(2'')-Ia.

Smith CA, Toth M, Bhattacharya M, Frase H, Vakulenko SB.

Acta Crystallogr D Biol Crystallogr. 2014 Jun;70(Pt 6):1561-71. doi: 10.1107/S1399004714005331. Epub 2014 May 23.

8.

The crystal structures of substrate and nucleotide complexes of Enterococcus faecium aminoglycoside-2''-phosphotransferase-IIa [APH(2'')-IIa] provide insights into substrate selectivity in the APH(2'') subfamily.

Young PG, Walanj R, Lakshmi V, Byrnes LJ, Metcalf P, Baker EN, Vakulenko SB, Smith CA.

J Bacteriol. 2009 Jul;191(13):4133-43. doi: 10.1128/JB.00149-09. Epub 2009 May 8.

9.

Mutant APH(2'')-IIa enzymes with increased activity against amikacin and isepamicin.

Toth M, Frase H, Chow JW, Smith C, Vakulenko SB.

Antimicrob Agents Chemother. 2010 Apr;54(4):1590-5. doi: 10.1128/AAC.01444-09. Epub 2010 Feb 9.

10.

Structure and function of APH(4)-Ia, a hygromycin B resistance enzyme.

Stogios PJ, Shakya T, Evdokimova E, Savchenko A, Wright GD.

J Biol Chem. 2011 Jan 21;286(3):1966-75. doi: 10.1074/jbc.M110.194266. Epub 2010 Nov 17. Erratum in: J Biol Chem. 2011 Dec 9;286(49):42786.

11.
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Developing a snapshot of the ATP binding domain(s) of aminoglycoside phosphotransferases.

Perlin MH, Brown SA, Dholakia JN.

Front Biosci. 1999 Jan 1;4:D63-71. Review.

PMID:
9872732
13.

Purification, characterization, and investigation of the mechanism of aminoglycoside 3'-phosphotransferase type Ia.

Siregar JJ, Miroshnikov K, Mobashery S.

Biochemistry. 1995 Oct 3;34(39):12681-8.

PMID:
7548020
14.

Active-site labeling of an aminoglycoside antibiotic phosphotransferase (APH(3')-IIIa).

McKay GA, Robinson RA, Lane WS, Wright GD.

Biochemistry. 1994 Nov 29;33(47):14115-20.

PMID:
7947822
15.

Aminoglycoside binding and catalysis specificity of aminoglycoside 2″-phosphotransferase IVa: A thermodynamic, structural and kinetic study.

Kaplan E, Guichou JF, Chaloin L, Kunzelmann S, Leban N, Serpersu EH, Lionne C.

Biochim Biophys Acta. 2016 Apr;1860(4):802-13. doi: 10.1016/j.bbagen.2016.01.016. Epub 2016 Jan 21.

16.

Aminoglycoside 2''-phosphotransferase type IIIa from Enterococcus.

Badarau A, Shi Q, Chow JW, Zajicek J, Mobashery S, Vakulenko S.

J Biol Chem. 2008 Mar 21;283(12):7638-47. doi: 10.1074/jbc.M709645200. Epub 2008 Jan 16.

17.
18.

Domain-domain interactions in the aminoglycoside antibiotic resistance enzyme AAC(6')-APH(2'').

Boehr DD, Daigle DM, Wright GD.

Biochemistry. 2004 Aug 3;43(30):9846-55.

PMID:
15274639
19.

The COOH terminus of aminoglycoside phosphotransferase (3')-IIIa is critical for antibiotic recognition and resistance.

Thompson PR, Schwartzenhauer J, Hughes DW, Berghuis AM, Wright GD.

J Biol Chem. 1999 Oct 22;274(43):30697-706.

20.

Nucleotide selectivity of antibiotic kinases.

Shakya T, Wright GD.

Antimicrob Agents Chemother. 2010 May;54(5):1909-13. doi: 10.1128/AAC.01570-09. Epub 2010 Mar 15.

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