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Chloroquine inhibits HMGB1 inflammatory signaling and protects mice from lethal sepsis.

Yang M, Cao L, Xie M, Yu Y, Kang R, Yang L, Zhao M, Tang D.

Biochem Pharmacol. 2013 Aug 1;86(3):410-8. doi: 10.1016/j.bcp.2013.05.013. Epub 2013 May 22.


Quercetin prevents LPS-induced high-mobility group box 1 release and proinflammatory function.

Tang D, Kang R, Xiao W, Zhang H, Lotze MT, Wang H, Xiao X.

Am J Respir Cell Mol Biol. 2009 Dec;41(6):651-60. doi: 10.1165/rcmb.2008-0119OC. Epub 2009 Mar 5.


Ethyl pyruvate prevents lethality in mice with established lethal sepsis and systemic inflammation.

Ulloa L, Ochani M, Yang H, Tanovic M, Halperin D, Yang R, Czura CJ, Fink MP, Tracey KJ.

Proc Natl Acad Sci U S A. 2002 Sep 17;99(19):12351-6. Epub 2002 Sep 3.


The aqueous extract of a popular herbal nutrient supplement, Angelica sinensis, protects mice against lethal endotoxemia and sepsis.

Wang H, Li W, Li J, Rendon-Mitchell B, Ochani M, Ashok M, Yang L, Yang H, Tracey KJ, Wang P, Sama AE.

J Nutr. 2006 Feb;136(2):360-5.


A dual-role of Gu-4 in suppressing HMGB1 secretion and blocking HMGB1 pro-inflammatory activity during inflammation.

Zhou H, Ji X, Wu Y, Xuan J, Qi Z, Shen L, Lan L, Li Q, Yin Z, Li Z, Zhao Z.

PLoS One. 2014 Mar 6;9(3):e89634. doi: 10.1371/journal.pone.0089634. eCollection 2014.


A major ingredient of green tea rescues mice from lethal sepsis partly by inhibiting HMGB1.

Li W, Ashok M, Li J, Yang H, Sama AE, Wang H.

PLoS One. 2007 Nov 7;2(11):e1153.


Penehyclidine hydrochloride inhibits the release of high-mobility group box 1 in lipopolysaccharide-activated RAW264.7 cells and cecal ligation and puncture-induced septic mice.

Yang Q, Liu X, Yao Z, Mao S, Wei Q, Chang Y.

J Surg Res. 2014 Jan;186(1):310-7. doi: 10.1016/j.jss.2013.08.015. Epub 2013 Sep 8.


Role of high mobility group box 1 in inflammatory disease: focus on sepsis.

Bae JS.

Arch Pharm Res. 2012 Sep;35(9):1511-23. doi: 10.1007/s12272-012-0901-5. Epub 2012 Oct 9. Review.


The inhibitory effect of lidocaine on the release of high mobility group box 1 in lipopolysaccharide-stimulated macrophages.

Wang HL, Zhang WH, Lei WF, Zhou CQ, Ye T.

Anesth Analg. 2011 Apr;112(4):839-44. doi: 10.1213/ANE.0b013e31820dca9f. Epub 2011 Feb 2.


A cardiovascular drug rescues mice from lethal sepsis by selectively attenuating a late-acting proinflammatory mediator, high mobility group box 1.

Li W, Li J, Ashok M, Wu R, Chen D, Yang L, Yang H, Tracey KJ, Wang P, Sama AE, Wang H.

J Immunol. 2007 Mar 15;178(6):3856-64.


Selective alpha7-nicotinic acetylcholine receptor agonist GTS-21 improves survival in murine endotoxemia and severe sepsis.

Pavlov VA, Ochani M, Yang LH, Gallowitsch-Puerta M, Ochani K, Lin X, Levi J, Parrish WR, Rosas-Ballina M, Czura CJ, Larosa GJ, Miller EJ, Tracey KJ, Al-Abed Y.

Crit Care Med. 2007 Apr;35(4):1139-44.


PACAP inhibit the release and cytokine activity of HMGB1 and improve the survival during lethal endotoxemia.

Tang Y, Lv B, Wang H, Xiao X, Zuo X.

Int Immunopharmacol. 2008 Dec 10;8(12):1646-51. doi: 10.1016/j.intimp.2008.07.014. Epub 2008 Aug 17.


Ghrelin protects against experimental sepsis by inhibiting high-mobility group box 1 release and by killing bacteria.

Chorny A, Anderson P, Gonzalez-Rey E, Delgado M.

J Immunol. 2008 Jun 15;180(12):8369-77.


Neuropeptides rescue mice from lethal sepsis by down-regulating secretion of the late-acting inflammatory mediator high mobility group box 1.

Chorny A, Delgado M.

Am J Pathol. 2008 May;172(5):1297-307. doi: 10.2353/ajpath.2008.070969. Epub 2008 Apr 1.


HMGB1 as a potential therapeutic target.

Wang H, Li W, Goldstein R, Tracey KJ, Sama AE.

Novartis Found Symp. 2007;280:73-85; discussion 85-91, 160-4. Review.


Endogenous HMGB1 is required in endotoxin tolerance.

Li S, Luo C, Yin C, Peng C, Han R, Zhou J, He Q, Zhou J.

J Surg Res. 2013 Nov;185(1):319-28. doi: 10.1016/j.jss.2013.05.062. Epub 2013 Jun 10.


Antiseptic effect of vicenin-2 and scolymoside from Cyclopia subternata (honeybush) in response to HMGB1 as a late sepsis mediator in vitro and in vivo.

Lee W, Yoon EK, Kim KM, Park DH, Bae JS.

Can J Physiol Pharmacol. 2015 Aug;93(8):709-20. doi: 10.1139/cjpp-2015-0021. Epub 2015 Apr 22.


Spermine protects mice against lethal sepsis partly by attenuating surrogate inflammatory markers.

Zhu S, Ashok M, Li J, Li W, Yang H, Wang P, Tracey KJ, Sama AE, Wang H.

Mol Med. 2009 Jul-Aug;15(7-8):275-82. doi: 10.2119/molmed.2009.00062. Epub 2009 May 1.


Dexmedetomidine inhibits the secretion of high mobility group box 1 from lipopolysaccharide-activated macrophages in vitro.

Chang Y, Huang X, Liu Z, Han G, Huang L, Xiong YC, Wang Z.

J Surg Res. 2013 May;181(2):308-14. doi: 10.1016/j.jss.2012.07.017. Epub 2012 Jul 26.


Modulation of TNF release by choline requires alpha7 subunit nicotinic acetylcholine receptor-mediated signaling.

Parrish WR, Rosas-Ballina M, Gallowitsch-Puerta M, Ochani M, Ochani K, Yang LH, Hudson L, Lin X, Patel N, Johnson SM, Chavan S, Goldstein RS, Czura CJ, Miller EJ, Al-Abed Y, Tracey KJ, Pavlov VA.

Mol Med. 2008 Sep-Oct;14(9-10):567-74. doi: 10.2119/2008-00079.Parrish.

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