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Items: 1 to 20 of 87

1.

Control of alveolar differentiation by the lineage transcription factors GATA6 and HOPX inhibits lung adenocarcinoma metastasis.

Cheung WK, Zhao M, Liu Z, Stevens LE, Cao PD, Fang JE, Westbrook TF, Nguyen DX.

Cancer Cell. 2013 Jun 10;23(6):725-38. doi: 10.1016/j.ccr.2013.04.009. Epub 2013 May 23.

2.

Hopping between differentiation states in lung adenocarcinoma.

Watanabe H, Meyerson M.

Cancer Cell. 2013 Jun 10;23(6):707-9. doi: 10.1016/j.ccr.2013.05.013.

3.

HOPX is methylated and exerts tumour-suppressive function through Ras-induced senescence in human lung cancer.

Chen Y, Yang L, Cui T, Pacyna-Gengelbach M, Petersen I.

J Pathol. 2015 Feb;235(3):397-407. doi: 10.1002/path.4469. Epub 2014 Dec 18.

PMID:
25345926
4.

Activation of GATA binding protein 6 (GATA6) sustains oncogenic lineage-survival in esophageal adenocarcinoma.

Lin L, Bass AJ, Lockwood WW, Wang Z, Silvers AL, Thomas DG, Chang AC, Lin J, Orringer MB, Li W, Glover TW, Giordano TJ, Lam WL, Meyerson M, Beer DG.

Proc Natl Acad Sci U S A. 2012 Mar 13;109(11):4251-6. doi: 10.1073/pnas.1011989109. Epub 2012 Feb 28.

5.

GATA6 regulates differentiation of distal lung epithelium.

Yang H, Lu MM, Zhang L, Whitsett JA, Morrisey EE.

Development. 2002 May;129(9):2233-46.

6.

Foxa2 and Cdx2 cooperate with Nkx2-1 to inhibit lung adenocarcinoma metastasis.

Li CM, Gocheva V, Oudin MJ, Bhutkar A, Wang SY, Date SR, Ng SR, Whittaker CA, Bronson RT, Snyder EL, Gertler FB, Jacks T.

Genes Dev. 2015 Sep 1;29(17):1850-62. doi: 10.1101/gad.267393.115.

7.

Gata6 is an important regulator of mouse pancreas development.

Decker K, Goldman DC, Grasch CL, Sussel L.

Dev Biol. 2006 Oct 15;298(2):415-29. Epub 2006 Jul 4.

8.

YAP inhibits squamous transdifferentiation of Lkb1-deficient lung adenocarcinoma through ZEB2-dependent DNp63 repression.

Gao Y, Zhang W, Han X, Li F, Wang X, Wang R, Fang Z, Tong X, Yao S, Li F, Feng Y, Sun Y, Hou Y, Yang Z, Guan K, Chen H, Zhang L, Ji H.

Nat Commun. 2014 Aug 13;5:4629. doi: 10.1038/ncomms5629.

PMID:
25115923
9.

Sox2 regulates the emergence of lung basal cells by directly activating the transcription of Trp63.

Ochieng JK, Schilders K, Kool H, Boerema-De Munck A, Buscop-Van Kempen M, Gontan C, Smits R, Grosveld FG, Wijnen RM, Tibboel D, Rottier RJ.

Am J Respir Cell Mol Biol. 2014 Aug;51(2):311-22. doi: 10.1165/rcmb.2013-0419OC.

PMID:
24669837
10.

An integrative analysis reveals functional targets of GATA6 transcriptional regulation in gastric cancer.

Sulahian R, Casey F, Shen J, Qian ZR, Shin H, Ogino S, Weir BA, Vazquez F, Liu XS, Hahn WC, Bass AJ, Chan V, Shivdasani RA.

Oncogene. 2014 Dec 4;33(49):5637-48. doi: 10.1038/onc.2013.517. Epub 2013 Dec 9.

11.

Downregulation of HOPX controls metastatic behavior in sarcoma cells and identifies genes associated with metastasis.

Kovárová D, Plachy J, Kosla J, Trejbalová K, Čermák V, Hejnar J.

Mol Cancer Res. 2013 Oct;11(10):1235-47. doi: 10.1158/1541-7786.MCR-12-0687. Epub 2013 Aug 12.

12.

Role of HOXB7 in regulation of progression and metastasis of human lung adenocarcinoma.

Yuan W, Zhang X, Xu Y, Li S, Hu Y, Wu S.

Mol Carcinog. 2014 Jan;53(1):49-57. doi: 10.1002/mc.21947. Epub 2012 Aug 21.

PMID:
22911672
13.

Spdef deletion rescues the crypt cell proliferation defect in conditional Gata6 null mouse small intestine.

Aronson BE, Stapleton KA, Vissers LA, Stokhuijzen E, Bruijnzeel H, Krasinski SD.

BMC Mol Biol. 2014 Jan 28;15:3. doi: 10.1186/1471-2199-15-3.

14.

Hop functions downstream of Nkx2.1 and GATA6 to mediate HDAC-dependent negative regulation of pulmonary gene expression.

Yin Z, Gonzales L, Kolla V, Rath N, Zhang Y, Lu MM, Kimura S, Ballard PL, Beers MF, Epstein JA, Morrisey EE.

Am J Physiol Lung Cell Mol Physiol. 2006 Aug;291(2):L191-9. Epub 2006 Mar 1.

15.

The transcriptional factor YY1 upregulates the novel invasion suppressor HLJ1 expression and inhibits cancer cell invasion.

Wang CC, Tsai MF, Hong TM, Chang GC, Chen CY, Yang WM, Chen JJ, Yang PC.

Oncogene. 2005 Jun 9;24(25):4081-93.

PMID:
15782117
16.

Obligate progression precedes lung adenocarcinoma dissemination.

Caswell DR, Chuang CH, Yang D, Chiou SH, Cheemalavagu S, Kim-Kiselak C, Connolly A, Winslow MM.

Cancer Discov. 2014 Jul;4(7):781-9. doi: 10.1158/2159-8290.CD-13-0862. Epub 2014 Apr 16.

17.

Neural lineage-specific homeoprotein BRN2 is directly involved in TTF1 expression in small-cell lung cancer.

Sakaeda M, Sato H, Ishii J, Miyata C, Kamma H, Shishido-Hara Y, Shimoyamada H, Fujiwara M, Endo T, Tanaka R, Kondo H, Goya T, Aoki I, Yazawa T.

Lab Invest. 2013 Apr;93(4):408-21. doi: 10.1038/labinvest.2013.2. Epub 2013 Jan 28.

18.

Upregulation of notch2 and six1 is associated with progression of early-stage lung adenocarcinoma and a more aggressive phenotype at advanced stages.

Mimae T, Okada M, Hagiyama M, Miyata Y, Tsutani Y, Inoue T, Murakami Y, Ito A.

Clin Cancer Res. 2012 Feb 15;18(4):945-55. doi: 10.1158/1078-0432.CCR-11-1946. Epub 2011 Dec 21.

19.

PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.

Liu Y, Zhang JB, Qin Y, Wang W, Wei L, Teng Y, Guo L, Zhang B, Lin Z, Liu J, Ren ZG, Ye QH, Xie Y.

Hepatology. 2013 Aug;58(2):692-705. doi: 10.1002/hep.26398.

PMID:
23505027
20.

Nicotine promotes initiation and progression of KRAS-induced pancreatic cancer via Gata6-dependent dedifferentiation of acinar cells in mice.

Hermann PC, Sancho P, Cañamero M, Martinelli P, Madriles F, Michl P, Gress T, de Pascual R, Gandia L, Guerra C, Barbacid M, Wagner M, Vieira CR, Aicher A, Real FX, Sainz B Jr, Heeschen C.

Gastroenterology. 2014 Nov;147(5):1119-33.e4. doi: 10.1053/j.gastro.2014.08.002. Epub 2014 Aug 12.

PMID:
25127677

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