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Reactive oxygen species mediate Cr(VI)-induced carcinogenesis through PI3K/AKT-dependent activation of GSK-3β/β-catenin signaling.

Son YO, Pratheeshkumar P, Wang L, Wang X, Fan J, Kim DH, Lee JY, Zhang Z, Lee JC, Shi X.

Toxicol Appl Pharmacol. 2013 Sep 1;271(2):239-48. doi: 10.1016/j.taap.2013.04.036. Epub 2013 May 22.


Cadmium induces carcinogenesis in BEAS-2B cells through ROS-dependent activation of PI3K/AKT/GSK-3β/β-catenin signaling.

Son YO, Wang L, Poyil P, Budhraja A, Hitron JA, Zhang Z, Lee JC, Shi X.

Toxicol Appl Pharmacol. 2012 Oct 15;264(2):153-60. doi: 10.1016/j.taap.2012.07.028. Epub 2012 Aug 3.


Troglitazone ameliorates high glucose-induced EMT and dysfunction of SGLTs through PI3K/Akt, GSK-3β, Snail1, and β-catenin in renal proximal tubule cells.

Lee YJ, Han HJ.

Am J Physiol Renal Physiol. 2010 May;298(5):F1263-75. doi: 10.1152/ajprenal.00475.2009. Epub 2009 Dec 16.


Luteolin inhibits Cr(VI)-induced malignant cell transformation of human lung epithelial cells by targeting ROS mediated multiple cell signaling pathways.

Pratheeshkumar P, Son YO, Divya SP, Roy RV, Hitron JA, Wang L, Kim D, Dai J, Asha P, Zhang Z, Wang Y, Shi X.

Toxicol Appl Pharmacol. 2014 Dec 1;281(2):230-41. doi: 10.1016/j.taap.2014.10.008. Epub 2014 Oct 23.


NADPH oxidase activation is required in reactive oxygen species generation and cell transformation induced by hexavalent chromium.

Wang X, Son YO, Chang Q, Sun L, Hitron JA, Budhraja A, Zhang Z, Ke Z, Chen F, Luo J, Shi X.

Toxicol Sci. 2011 Oct;123(2):399-410. doi: 10.1093/toxsci/kfr180. Epub 2011 Jul 8.


Constitutive activation of epidermal growth factor receptor promotes tumorigenesis of Cr(VI)-transformed cells through decreased reactive oxygen species and apoptosis resistance development.

Kim D, Dai J, Fai LY, Yao H, Son YO, Wang L, Pratheeshkumar P, Kondo K, Shi X, Zhang Z.

J Biol Chem. 2015 Jan 23;290(4):2213-24. doi: 10.1074/jbc.M114.619783. Epub 2014 Dec 4.


p38 Signaling-mediated hypoxia-inducible factor 1alpha and vascular endothelial growth factor induction by Cr(VI) in DU145 human prostate carcinoma cells.

Gao N, Jiang BH, Leonard SS, Corum L, Zhang Z, Roberts JR, Antonini J, Zheng JZ, Flynn DC, Castranova V, Shi X.

J Biol Chem. 2002 Nov 22;277(47):45041-8. Epub 2002 Sep 3.


2,3,7,8-Tetrachlorodibenzo-p-dioxin stimulates proliferation of HAPI microglia by affecting the Akt/GSK-3β/cyclin D1 signaling pathway.

Xu G, Li Y, Yoshimoto K, Wu Q, Chen G, Iwata T, Mizusawa N, Wan C, Nie X.

Toxicol Lett. 2014 Jan 30;224(3):362-70. doi: 10.1016/j.toxlet.2013.11.003. Epub 2013 Nov 11.


LEOPARD-type SHP2 mutant Gln510Glu attenuates cardiomyocyte differentiation and promotes cardiac hypertrophy via dysregulation of Akt/GSK-3β/β-catenin signaling.

Ishida H, Kogaki S, Narita J, Ichimori H, Nawa N, Okada Y, Takahashi K, Ozono K.

Am J Physiol Heart Circ Physiol. 2011 Oct;301(4):H1531-9. doi: 10.1152/ajpheart.00216.2011. Epub 2011 Jul 29.


Cr(VI) induces mitochondrial-mediated and caspase-dependent apoptosis through reactive oxygen species-mediated p53 activation in JB6 Cl41 cells.

Son YO, Hitron JA, Wang X, Chang Q, Pan J, Zhang Z, Liu J, Wang S, Lee JC, Shi X.

Toxicol Appl Pharmacol. 2010 Jun 1;245(2):226-35. doi: 10.1016/j.taap.2010.03.004. Epub 2010 Mar 16.


Protective effect of proanthocyanidins on anoxia-reoxygenation injury of myocardial cells mediated by the PI3K/Akt/GSK-3β pathway and mitochondrial ATP-sensitive potassium channel.

Hu Y, Li L, Yin W, Shen L, You B, Gao H.

Mol Med Rep. 2014 Oct;10(4):2051-8. doi: 10.3892/mmr.2014.2459. Epub 2014 Aug 6.


Glycogen-Synthase Kinase3beta/beta-catenin axis promotes angiogenesis through activation of vascular endothelial growth factor signaling in endothelial cells.

Skurk C, Maatz H, Rocnik E, Bialik A, Force T, Walsh K.

Circ Res. 2005 Feb 18;96(3):308-18. Epub 2005 Jan 20.


Arsenic and chromium in drinking water promote tumorigenesis in a mouse colitis-associated colorectal cancer model and the potential mechanism is ROS-mediated Wnt/β-catenin signaling pathway.

Wang X, Mandal AK, Saito H, Pulliam JF, Lee EY, Ke ZJ, Lu J, Ding S, Li L, Shelton BJ, Tucker T, Evers BM, Zhang Z, Shi X.

Toxicol Appl Pharmacol. 2012 Jul 1;262(1):11-21. doi: 10.1016/j.taap.2012.04.014. Epub 2012 Apr 19.


The dual roles of c-Jun NH2-terminal kinase signaling in Cr(VI)-induced apoptosis in JB6 cells.

Son YO, Hitron JA, Cheng S, Budhraja A, Zhang Z, Lan Guo N, Lee JC, Shi X.

Toxicol Sci. 2011 Feb;119(2):335-45. doi: 10.1093/toxsci/kfq335. Epub 2010 Nov 3.


Galectin-3 mediates nuclear beta-catenin accumulation and Wnt signaling in human colon cancer cells by regulation of glycogen synthase kinase-3beta activity.

Song S, Mazurek N, Liu C, Sun Y, Ding QQ, Liu K, Hung MC, Bresalier RS.

Cancer Res. 2009 Feb 15;69(4):1343-9. doi: 10.1158/0008-5472.CAN-08-4153. Epub 2009 Feb 3.


The curry spice curcumin attenuates beta-amyloid-induced toxicity through beta-catenin and PI3K signaling in rat organotypic hippocampal slice culture.

Hoppe JB, Frozza RL, Pires EN, Meneghetti AB, Salbego C.

Neurol Res. 2013 Oct;35(8):857-66. doi: 10.1179/1743132813Y.0000000225. Epub 2013 May 14.


Embelin-Induced Apoptosis of Human Prostate Cancer Cells Is Mediated through Modulation of Akt and β-Catenin Signaling.

Park N, Baek HS, Chun YJ.

PLoS One. 2015 Aug 7;10(8):e0134760. doi: 10.1371/journal.pone.0134760. eCollection 2015.


Honokiol induces autophagy of neuroblastoma cells through activating the PI3K/Akt/mTOR and endoplasmic reticular stress/ERK1/2 signaling pathways and suppressing cell migration.

Yeh PS, Wang W, Chang YA, Lin CJ, Wang JJ, Chen RM.

Cancer Lett. 2016 Jan 1;370(1):66-77. doi: 10.1016/j.canlet.2015.08.030. Epub 2015 Oct 21.


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