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Items: 1 to 20 of 111

1.

Multi-parameter in vitro toxicity testing of crizotinib, sunitinib, erlotinib, and nilotinib in human cardiomyocytes.

Doherty KR, Wappel RL, Talbert DR, Trusk PB, Moran DM, Kramer JW, Brown AM, Shell SA, Bacus S.

Toxicol Appl Pharmacol. 2013 Oct 1;272(1):245-55. doi: 10.1016/j.taap.2013.04.027.

PMID:
23707608
2.

Use of human stem cell derived cardiomyocytes to examine sunitinib mediated cardiotoxicity and electrophysiological alterations.

Cohen JD, Babiarz JE, Abrams RM, Guo L, Kameoka S, Chiao E, Taunton J, Kolaja KL.

Toxicol Appl Pharmacol. 2011 Nov 15;257(1):74-83. doi: 10.1016/j.taap.2011.08.020.

PMID:
21906609
3.

Liposomes ameliorate Crizotinib- and Nilotinib-induced inhibition of the cardiac IKr channel and QTc prolongation.

Shopp GM, Helson L, Bouchard A, Salvail D, Majeed M.

Anticancer Res. 2014 Sep;34(9):4733-40.

PMID:
25202051
4.

Effect of the multitargeted tyrosine kinase inhibitors imatinib, dasatinib, sunitinib, and sorafenib on mitochondrial function in isolated rat heart mitochondria and H9c2 cells.

Will Y, Dykens JA, Nadanaciva S, Hirakawa B, Jamieson J, Marroquin LD, Hynes J, Patyna S, Jessen BA.

Toxicol Sci. 2008 Nov;106(1):153-61. doi: 10.1093/toxsci/kfn157.

5.

Structural and functional screening in human induced-pluripotent stem cell-derived cardiomyocytes accurately identifies cardiotoxicity of multiple drug types.

Doherty KR, Talbert DR, Trusk PB, Moran DM, Shell SA, Bacus S.

Toxicol Appl Pharmacol. 2015 May 15;285(1):51-60. doi: 10.1016/j.taap.2015.03.008.

PMID:
25841593
6.

A multi-parameter in vitro screen in human stem cell-derived cardiomyocytes identifies ponatinib-induced structural and functional cardiac toxicity.

Talbert DR, Doherty KR, Trusk PB, Moran DM, Shell SA, Bacus S.

Toxicol Sci. 2015 Jan;143(1):147-55. doi: 10.1093/toxsci/kfu215.

7.

Sunitinib-induced cardiotoxicity is mediated by off-target inhibition of AMP-activated protein kinase.

Kerkela R, Woulfe KC, Durand JB, Vagnozzi R, Kramer D, Chu TF, Beahm C, Chen MH, Force T.

Clin Transl Sci. 2009 Feb;2(1):15-25. doi: 10.1111/j.1752-8062.2008.00090.x.

8.

HIV Tat protein inhibits hERG K+ channels: a potential mechanism of HIV infection induced LQTs.

Bai YL, Liu HB, Sun B, Zhang Y, Li Q, Hu CW, Zhu JX, Gong DM, Teng X, Zhang Q, Yang BF, Dong DL.

J Mol Cell Cardiol. 2011 Nov;51(5):876-80. doi: 10.1016/j.yjmcc.2011.07.017.

PMID:
21820442
9.

Exploration of human, rat, and rabbit embryonic cardiomyocytes suggests K-channel block as a common teratogenic mechanism.

Danielsson C, Brask J, Sköld AC, Genead R, Andersson A, Andersson U, Stockling K, Pehrson R, Grinnemo KH, Salari S, Hellmold H, Danielsson B, Sylvén C, Elinder F.

Cardiovasc Res. 2013 Jan 1;97(1):23-32. doi: 10.1093/cvr/cvs296.

10.

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity.

Liang P, Lan F, Lee AS, Gong T, Sanchez-Freire V, Wang Y, Diecke S, Sallam K, Knowles JW, Wang PJ, Nguyen PK, Bers DM, Robbins RC, Wu JC.

Circulation. 2013 Apr 23;127(16):1677-91. doi: 10.1161/CIRCULATIONAHA.113.001883.

11.

A novel preclinical strategy for identifying cardiotoxic kinase inhibitors and mechanisms of cardiotoxicity.

Cheng H, Kari G, Dicker AP, Rodeck U, Koch WJ, Force T.

Circ Res. 2011 Dec 9;109(12):1401-9. doi: 10.1161/CIRCRESAHA.111.255695.

12.

High-performance beating pattern function of human induced pluripotent stem cell-derived cardiomyocyte-based biosensors for hERG inhibition recognition.

Hu N, Wang T, Wang Q, Zhou J, Zou L, Su K, Wu J, Wang P.

Biosens Bioelectron. 2015 May 15;67:146-53. doi: 10.1016/j.bios.2014.07.080.

PMID:
25153933
13.

Identification of IKr and its trafficking disruption induced by probucol in cultured neonatal rat cardiomyocytes.

Guo J, Massaeli H, Li W, Xu J, Luo T, Shaw J, Kirshenbaum LA, Zhang S.

J Pharmacol Exp Ther. 2007 Jun;321(3):911-20.

14.

Preservation of cardiomyocytes from the adult heart.

Abi-Gerges N, Pointon A, Pullen GF, Morton MJ, Oldman KL, Armstrong D, Valentin JP, Pollard CE.

J Mol Cell Cardiol. 2013 Nov;64:108-19. doi: 10.1016/j.yjmcc.2013.09.004.

PMID:
24051370
15.

Characterization of human-induced pluripotent stem cell-derived cardiomyocytes: bioenergetics and utilization in safety screening.

Rana P, Anson B, Engle S, Will Y.

Toxicol Sci. 2012 Nov;130(1):117-31. doi: 10.1093/toxsci/kfs233.

16.

hERG K+ channel-associated cardiac effects of the antidepressant drug desipramine.

Staudacher I, Wang L, Wan X, Obers S, Wenzel W, Tristram F, Koschny R, Staudacher K, Kisselbach J, Koelsch P, Schweizer PA, Katus HA, Ficker E, Thomas D.

Naunyn Schmiedebergs Arch Pharmacol. 2011 Feb;383(2):119-39. doi: 10.1007/s00210-010-0583-9.

PMID:
21120454
17.

State-dependent block of HERG potassium channels by R-roscovitine: implications for cancer therapy.

Ganapathi SB, Kester M, Elmslie KS.

Am J Physiol Cell Physiol. 2009 Apr;296(4):C701-10. doi: 10.1152/ajpcell.00633.2008.

18.

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment.

Abassi YA, Xi B, Li N, Ouyang W, Seiler A, Watzele M, Kettenhofen R, Bohlen H, Ehlich A, Kolossov E, Wang X, Xu X.

Br J Pharmacol. 2012 Mar;165(5):1424-41. doi: 10.1111/j.1476-5381.2011.01623.x.

19.

Cardiac safety pharmacology: from human ether-a-gogo related gene channel block towards induced pluripotent stem cell based disease models.

Kraushaar U, Meyer T, Hess D, Gepstein L, Mummery CL, Braam SR, Guenther E.

Expert Opin Drug Saf. 2012 Mar;11(2):285-98. doi: 10.1517/14740338.2012.639358. Review.

PMID:
22103746
20.

A human ether-á-go-go-related (hERG) ion channel atomistic model generated by long supercomputer molecular dynamics simulations and its use in predicting drug cardiotoxicity.

Anwar-Mohamed A, Barakat KH, Bhat R, Noskov SY, Tyrrell DL, Tuszynski JA, Houghton M.

Toxicol Lett. 2014 Nov 4;230(3):382-92. doi: 10.1016/j.toxlet.2014.08.007.

PMID:
25127758
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