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ASMase is required for chronic alcohol induced hepatic endoplasmic reticulum stress and mitochondrial cholesterol loading.

Fernandez A, Matias N, Fucho R, Ribas V, Von Montfort C, Nuño N, Baulies A, Martinez L, Tarrats N, Mari M, Colell A, Morales A, Dubuquoy L, Mathurin P, Bataller R, Caballeria J, Elena M, Balsinde J, Kaplowitz N, Garcia-Ruiz C, Fernandez-Checa JC.

J Hepatol. 2013 Oct;59(4):805-13. doi: 10.1016/j.jhep.2013.05.023. Epub 2013 May 23.


ASMase regulates autophagy and lysosomal membrane permeabilization and its inhibition prevents early stage non-alcoholic steatohepatitis.

Fucho R, Martínez L, Baulies A, Torres S, Tarrats N, Fernandez A, Ribas V, Astudillo AM, Balsinde J, Garcia-Rovés P, Elena M, Bergheim I, Lotersztajn S, Trautwein C, Appelqvist H, Paton AW, Paton JC, Czaja MJ, Kaplowitz N, Fernandez-Checa JC, García-Ruiz C.

J Hepatol. 2014 Nov;61(5):1126-34. doi: 10.1016/j.jhep.2014.06.009. Epub 2014 Jun 16.


Mitochondrial cholesterol accumulation in alcoholic liver disease: Role of ASMase and endoplasmic reticulum stress.

Marí M, Morales A, Colell A, García-Ruiz C, Fernández-Checa JC.

Redox Biol. 2014;3:100-8. doi: 10.1016/j.redox.2014.09.005. Epub 2014 Sep 28. Review.


Unfolding new mechanisms of alcoholic liver disease in the endoplasmic reticulum.

Kaplowitz N, Ji C.

J Gastroenterol Hepatol. 2006 Oct;21 Suppl 3:S7-9. Review.


Homocysteine Induces Hepatic Steatosis Involving ER Stress Response in High Methionine Diet-Fed Mice.

Ai Y, Sun Z, Peng C, Liu L, Xiao X, Li J.

Nutrients. 2017 Apr 1;9(4). pii: E346. doi: 10.3390/nu9040346.


Inhibition of adiponectin production by homocysteine: a potential mechanism for alcoholic liver disease.

Song Z, Zhou Z, Deaciuc I, Chen T, McClain CJ.

Hepatology. 2008 Mar;47(3):867-79. doi: 10.1002/hep.22074.


Role of TNF-alpha in ethanol-induced hyperhomocysteinemia and murine alcoholic liver injury.

Ji C, Deng Q, Kaplowitz N.

Hepatology. 2004 Aug;40(2):442-51.


Reducing endoplasmic reticulum stress does not improve steatohepatitis in mice fed a methionine- and choline-deficient diet.

Henkel AS, Dewey AM, Anderson KA, Olivares S, Green RM.

Am J Physiol Gastrointest Liver Physiol. 2012 Jul;303(1):G54-9. doi: 10.1152/ajpgi.00052.2012. Epub 2012 May 3.


Cholesterol and sphingolipids in alcohol-induced liver injury.

Fernández A, Colell A, Garcia-Ruiz C, Fernandez-Checa JC.

J Gastroenterol Hepatol. 2008 Mar;23 Suppl 1:S9-15. doi: 10.1111/j.1440-1746.2007.05280.x. Review.


The Role of Ceramide in the Pathogenesis of Alcoholic Liver Disease.

Yang L, Jin GH, Zhou JY.

Alcohol Alcohol. 2016 May;51(3):251-7. doi: 10.1093/alcalc/agv119. Epub 2015 Oct 28. Review.


Luteolin alleviates alcoholic liver disease induced by chronic and binge ethanol feeding in mice.

Liu G, Zhang Y, Liu C, Xu D, Zhang R, Cheng Y, Pan Y, Huang C, Chen Y.

J Nutr. 2014 Jul;144(7):1009-15. doi: 10.3945/jn.114.193128. Epub 2014 May 14.


Pharmacologic ER stress induces non-alcoholic steatohepatitis in an animal model.

Lee JS, Zheng Z, Mendez R, Ha SW, Xie Y, Zhang K.

Toxicol Lett. 2012 May 20;211(1):29-38. doi: 10.1016/j.toxlet.2012.02.017. Epub 2012 Mar 5.


Acidic sphingomyelinase downregulates the liver-specific methionine adenosyltransferase 1A, contributing to tumor necrosis factor-induced lethal hepatitis.

Marí M, Colell A, Morales A, Pañeda C, Varela-Nieto I, García-Ruiz C, Fernández-Checa JC.

J Clin Invest. 2004 Mar;113(6):895-904.


Endoplasmic reticulum stress mediates amyloid β neurotoxicity via mitochondrial cholesterol trafficking.

Barbero-Camps E, Fernández A, Baulies A, Martinez L, Fernández-Checa JC, Colell A.

Am J Pathol. 2014 Jul;184(7):2066-81. doi: 10.1016/j.ajpath.2014.03.014. Epub 2014 May 9.


Absence of adipose triglyceride lipase protects from hepatic endoplasmic reticulum stress in mice.

Fuchs CD, Claudel T, Kumari P, Haemmerle G, Pollheimer MJ, Stojakovic T, Scharnagl H, Halilbasic E, Gumhold J, Silbert D, Koefeler H, Trauner M.

Hepatology. 2012 Jul;56(1):270-80. doi: 10.1002/hep.25601. Epub 2012 May 29.


Homocysteine-induced endoplasmic reticulum stress causes dysregulation of the cholesterol and triglyceride biosynthetic pathways.

Werstuck GH, Lentz SR, Dayal S, Hossain GS, Sood SK, Shi YY, Zhou J, Maeda N, Krisans SK, Malinow MR, Austin RC.

J Clin Invest. 2001 May;107(10):1263-73.


Lysosomal Cholesterol Accumulation Sensitizes To Acetaminophen Hepatotoxicity by Impairing Mitophagy.

Baulies A, Ribas V, Núñez S, Torres S, Alarcón-Vila C, Martínez L, Suda J, Ybanez MD, Kaplowitz N, García-Ruiz C, Fernández-Checa JC.

Sci Rep. 2015 Dec 11;5:18017. doi: 10.1038/srep18017.

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