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SHIP2 regulates epithelial cell polarity through its lipid product, which binds to Dlg1, a pathway subverted by hepatitis C virus core protein.

Awad A, Sar S, Barré R, Cariven C, Marin M, Salles JP, Erneux C, Samuel D, Gassama-Diagne A.

Mol Biol Cell. 2013 Jul;24(14):2171-85. doi: 10.1091/mbc.E12-08-0626. Epub 2013 May 22.


Dual role of SRC homology domain 2-containing inositol phosphatase 2 in the regulation of platelet-derived growth factor and insulin-like growth factor I signaling in rat vascular smooth muscle cells.

Sasaoka T, Kikuchi K, Wada T, Sato A, Hori H, Murakami S, Fukui K, Ishihara H, Aota R, Kimura I, Kobayashi M.

Endocrinology. 2003 Sep;144(9):4204-14.


SHIP2 Regulates Lumen Generation, Cell Division, and Ciliogenesis through the Control of Basolateral to Apical Lumen Localization of Aurora A and HEF 1.

Hamze-Komaiha O, Sarr S, Arlot-Bonnemains Y, Samuel D, Gassama-Diagne A.

Cell Rep. 2016 Dec 6;17(10):2738-2752. doi: 10.1016/j.celrep.2016.11.033.


PI3K/SHIP2/PTEN pathway in cell polarity and hepatitis C virus pathogenesis.

Awad A, Gassama-Diagne A.

World J Hepatol. 2017 Jan 8;9(1):18-29. doi: 10.4254/wjh.v9.i1.18. Review.


Silencer of death domains (SODD) inhibits skeletal muscle and kidney enriched inositol 5-phosphatase (SKIP) and regulates phosphoinositide 3-kinase (PI3K)/Akt signaling to the actin cytoskeleton.

Rahman P, Huysmans RD, Wiradjaja F, Gurung R, Ooms LM, Sheffield DA, Dyson JM, Layton MJ, Sriratana A, Takada H, Tiganis T, Mitchell CA.

J Biol Chem. 2011 Aug 26;286(34):29758-70. doi: 10.1074/jbc.M111.263103. Epub 2011 Jun 28.


Regulation of PDGF-stimulated SHIP2 tyrosine phosphorylation and association with Shc in 3T3-L1 preadipocytes.

Artemenko Y, Gagnon A, Ibrahim S, Sorisky A.

J Cell Physiol. 2007 Jun;211(3):598-607.


Serum withdrawal-induced accumulation of phosphoinositide 3-kinase lipids in differentiating 3T3-L6 myoblasts: distinct roles for Ship2 and PTEN.

Mandl A, Sarkes D, Carricaburu V, Jung V, Rameh L.

Mol Cell Biol. 2007 Dec;27(23):8098-112. Epub 2007 Sep 24.


Regulation of EphA2 receptor endocytosis by SHIP2 lipid phosphatase via phosphatidylinositol 3-Kinase-dependent Rac1 activation.

Zhuang G, Hunter S, Hwang Y, Chen J.

J Biol Chem. 2007 Jan 26;282(4):2683-94. Epub 2006 Nov 29.


Phosphatidylinositol 3,4,5-trisphosphate modulation in SHIP2-deficient mouse embryonic fibroblasts.

Blero D, Zhang J, Pesesse X, Payrastre B, Dumont JE, Schurmans S, Erneux C.

FEBS J. 2005 May;272(10):2512-22.


Overexpression of SH2-containing inositol phosphatase 2 results in negative regulation of insulin-induced metabolic actions in 3T3-L1 adipocytes via its 5'-phosphatase catalytic activity.

Wada T, Sasaoka T, Funaki M, Hori H, Murakami S, Ishiki M, Haruta T, Asano T, Ogawa W, Ishihara H, Kobayashi M.

Mol Cell Biol. 2001 Mar;21(5):1633-46.


Regulation of protein kinase B activity by PTEN and SHIP2 in human prostate-derived cell lines.

Sharrard RM, Maitland NJ.

Cell Signal. 2007 Jan;19(1):129-38. Epub 2006 Jun 7.


The association between the SH2-containing inositol polyphosphate 5-Phosphatase 2 (SHIP2) and the adaptor protein APS has an impact on biochemical properties of both partners.

Onnockx S, De Schutter J, Blockmans M, Xie J, Jacobs C, Vanderwinden JM, Erneux C, Pirson I.

J Cell Physiol. 2008 Jan;214(1):260-72.


The influence of anionic lipids on SHIP2 phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase activity.

Vandeput F, Backers K, Villeret V, Pesesse X, Erneux C.

Cell Signal. 2006 Dec;18(12):2193-9. Epub 2006 May 23.


The inositol 5-phosphatase SHIP2 is an effector of RhoA and is involved in cell polarity and migration.

Kato K, Yazawa T, Taki K, Mori K, Wang S, Nishioka T, Hamaguchi T, Itoh T, Takenawa T, Kataoka C, Matsuura Y, Amano M, Murohara T, Kaibuchi K.

Mol Biol Cell. 2012 Jul;23(13):2593-604. doi: 10.1091/mbc.E11-11-0958. Epub 2012 May 16.


PTEN, but not SHIP2, suppresses insulin signaling through the phosphatidylinositol 3-kinase/Akt pathway in 3T3-L1 adipocytes.

Tang X, Powelka AM, Soriano NA, Czech MP, Guilherme A.

J Biol Chem. 2005 Jun 10;280(23):22523-9. Epub 2005 Apr 11.


SHIP2 multiple functions: a balance between a negative control of PtdIns(3,4,5)P₃ level, a positive control of PtdIns(3,4)P₂ production, and intrinsic docking properties.

Erneux C, Edimo WE, Deneubourg L, Pirson I.

J Cell Biochem. 2011 Sep;112(9):2203-9. doi: 10.1002/jcb.23146. Review.


SH2-containing inositol phosphatase 2 negatively regulates insulin-induced glycogen synthesis in L6 myotubes.

Sasaoka T, Hori H, Wada T, Ishiki M, Haruta T, Ishihara H, Kobayashi M.

Diabetologia. 2001 Oct;44(10):1258-67.


Nephrin regulates lamellipodia formation by assembling a protein complex that includes Ship2, filamin and lamellipodin.

Venkatareddy M, Cook L, Abuarquob K, Verma R, Garg P.

PLoS One. 2011;6(12):e28710. doi: 10.1371/journal.pone.0028710. Epub 2011 Dec 14.

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