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Dual regulation of cadmium-induced apoptosis by mTORC1 through selective induction of IRE1 branches in unfolded protein response.

Kato H, Katoh R, Kitamura M.

PLoS One. 2013 May 16;8(5):e64344. doi: 10.1371/journal.pone.0064344. Print 2013.


mTORC1 serves ER stress-triggered apoptosis via selective activation of the IRE1-JNK pathway.

Kato H, Nakajima S, Saito Y, Takahashi S, Katoh R, Kitamura M.

Cell Death Differ. 2012 Feb;19(2):310-20. doi: 10.1038/cdd.2011.98. Epub 2011 Jul 22.


Atypical, bidirectional regulation of cadmium-induced apoptosis via distinct signaling of unfolded protein response.

Yokouchi M, Hiramatsu N, Hayakawa K, Kasai A, Takano Y, Yao J, Kitamura M.

Cell Death Differ. 2007 Aug;14(8):1467-74. Epub 2007 Apr 27.


Mammalian target of rapamycin complex 1 (mTORC1) enhances bortezomib-induced death in tuberous sclerosis complex (TSC)-null cells by a c-MYC-dependent induction of the unfolded protein response.

Babcock JT, Nguyen HB, He Y, Hendricks JW, Wek RC, Quilliam LA.

J Biol Chem. 2013 May 31;288(22):15687-98. doi: 10.1074/jbc.M112.431056. Epub 2013 Apr 23.


Cadmium activates the mitogen-activated protein kinase (MAPK) pathway via induction of reactive oxygen species and inhibition of protein phosphatases 2A and 5.

Chen L, Liu L, Huang S.

Free Radic Biol Med. 2008 Oct 1;45(7):1035-44. doi: 10.1016/j.freeradbiomed.2008.07.011. Epub 2008 Jul 26.


Involvement of selective reactive oxygen species upstream of proapoptotic branches of unfolded protein response.

Yokouchi M, Hiramatsu N, Hayakawa K, Okamura M, Du S, Kasai A, Takano Y, Shitamura A, Shimada T, Yao J, Kitamura M.

J Biol Chem. 2008 Feb 15;283(7):4252-60. Epub 2007 Dec 17.


Rapamycin prevents cadmium-induced neuronal cell death via targeting both mTORC1 and mTORC2 pathways.

Xu C, Liu C, Liu L, Zhang R, Zhang H, Chen S, Luo Y, Chen L, Huang S.

Neuropharmacology. 2015 Oct;97:35-45. doi: 10.1016/j.neuropharm.2015.05.008. Epub 2015 May 19.


Cadmium induces apoptosis in pancreatic β-cells through a mitochondria-dependent pathway: the role of oxidative stress-mediated c-Jun N-terminal kinase activation.

Chang KC, Hsu CC, Liu SH, Su CC, Yen CC, Lee MJ, Chen KL, Ho TJ, Hung DZ, Wu CC, Lu TH, Su YC, Chen YW, Huang CF.

PLoS One. 2013;8(2):e54374. doi: 10.1371/journal.pone.0054374. Epub 2013 Feb 6.


Cadmium induction of reactive oxygen species activates the mTOR pathway, leading to neuronal cell death.

Chen L, Xu B, Liu L, Luo Y, Zhou H, Chen W, Shen T, Han X, Kontos CD, Huang S.

Free Radic Biol Med. 2011 Mar 1;50(5):624-32. doi: 10.1016/j.freeradbiomed.2010.12.032. Epub 2010 Dec 30.


VEGF Signals through ATF6 and PERK to promote endothelial cell survival and angiogenesis in the absence of ER stress.

Karali E, Bellou S, Stellas D, Klinakis A, Murphy C, Fotsis T.

Mol Cell. 2014 May 22;54(4):559-72. doi: 10.1016/j.molcel.2014.03.022. Epub 2014 Apr 17.


Aberrant, differential and bidirectional regulation of the unfolded protein response towards cell survival by 3'-deoxyadenosine.

Kitamura M, Kato H, Saito Y, Nakajima S, Takahashi S, Johno H, Gu L, Katoh R.

Cell Death Differ. 2011 Dec;18(12):1876-88. doi: 10.1038/cdd.2011.63. Epub 2011 May 20.


Pleiotropic potential of dehydroxymethylepoxyquinomicin for NF-κB suppression via reactive oxygen species and unfolded protein response.

Nakajima S, Kato H, Gu L, Takahashi S, Johno H, Umezawa K, Kitamura M.

J Immunol. 2013 Jun 15;190(12):6559-69. doi: 10.4049/jimmunol.1300155. Epub 2013 May 20.


Attenuation of unfolded protein response and apoptosis by mReg2 induced GRP78 in mouse insulinoma cells.

Liu L, Chowdhury S, Fang X, Liu JL, Srikant CB.

FEBS Lett. 2014 May 29;588(11):2016-24. doi: 10.1016/j.febslet.2014.04.030. Epub 2014 May 4.


Celastrol prevents cadmium-induced neuronal cell death by blocking reactive oxygen species-mediated mammalian target of rapamycin pathway.

Zhang R, Zhang N, Zhang H, Liu C, Dong X, Wang X, Zhu Y, Xu C, Liu L, Yang S, Huang S, Chen L.

Br J Pharmacol. 2017 Jan;174(1):82-100. doi: 10.1111/bph.13655. Epub 2016 Nov 21.


Cadmium-induced teratogenicity: association with ROS-mediated endoplasmic reticulum stress in placenta.

Wang Z, Wang H, Xu ZM, Ji YL, Chen YH, Zhang ZH, Zhang C, Meng XH, Zhao M, Xu DX.

Toxicol Appl Pharmacol. 2012 Mar 1;259(2):236-47. doi: 10.1016/j.taap.2012.01.001. Epub 2012 Jan 9.


MicroRNA148b-3p inhibits mTORC1-dependent apoptosis in diabetes by repressing TNFR2 in proximal tubular cells.

Kuwagata S, Kume S, Chin-Kanasaki M, Araki H, Araki S, Nakazawa J, Sugaya T, Koya D, Haneda M, Maegawa H, Uzu T.

Kidney Int. 2016 Dec;90(6):1211-1225. doi: 10.1016/j.kint.2016.06.036. Epub 2016 Aug 31.


Calcium signaling is involved in cadmium-induced neuronal apoptosis via induction of reactive oxygen species and activation of MAPK/mTOR network.

Xu B, Chen S, Luo Y, Chen Z, Liu L, Zhou H, Chen W, Shen T, Han X, Chen L, Huang S.

PLoS One. 2011 Apr 22;6(4):e19052. doi: 10.1371/journal.pone.0019052.


N-acetyl-L-cysteine protects against cadmium-induced neuronal apoptosis by inhibiting ROS-dependent activation of Akt/mTOR pathway in mouse brain.

Chen S, Ren Q, Zhang J, Ye Y, Zhang Z, Xu Y, Guo M, Ji H, Xu C, Gu C, Gao W, Huang S, Chen L.

Neuropathol Appl Neurobiol. 2014 Oct;40(6):759-77. doi: 10.1111/nan.12103.


The oxidative stress: endoplasmic reticulum stress axis in cadmium toxicity.

Kitamura M, Hiramatsu N.

Biometals. 2010 Oct;23(5):941-50. doi: 10.1007/s10534-010-9296-2. Epub 2010 Feb 4. Review.


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