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In vitro and in vivo evaluation of the caspase-3 substrate-based radiotracer [(18)F]-CP18 for PET imaging of apoptosis in tumors.

Xia CF, Chen G, Gangadharmath U, Gomez LF, Liang Q, Mu F, Mocharla VP, Su H, Szardenings AK, Walsh JC, Zhao T, Kolb HC.

Mol Imaging Biol. 2013 Dec;15(6):748-57. doi: 10.1007/s11307-013-0646-7.


Evaluation of [(18)F]-CP18 as a PET imaging tracer for apoptosis.

Su H, Chen G, Gangadharmath U, Gomez LF, Liang Q, Mu F, Mocharla VP, Szardenings AK, Walsh JC, Xia CF, Yu C, Kolb HC.

Mol Imaging Biol. 2013 Dec;15(6):739-47. doi: 10.1007/s11307-013-0644-9.


Noninvasive molecular imaging of apoptosis in a mouse model of anthracycline-induced cardiotoxicity.

Su H, Gorodny N, Gomez LF, Gangadharmath U, Mu F, Chen G, Walsh JC, Szardenings K, Kolb HC, Tamarappoo B.

Circ Cardiovasc Imaging. 2015 Feb;8(2):e001952. doi: 10.1161/CIRCIMAGING.114.001952.


Evaluation of [18F]CP18 as a Substrate-Based Apoptosis Imaging Agent for the Assessment of Early Treatment Response in Oncology.

Rapic S, Vangestel C, Elvas F, Verhaeghe J, den Wyngaert TV, Wyffels L, Pauwels P, Staelens S, Stroobants S.

Mol Imaging Biol. 2017 Aug;19(4):560-569. doi: 10.1007/s11307-016-1037-7.


A peptide-based positron emission tomography probe for in vivo detection of caspase activity in apoptotic cells.

Hight MR, Cheung YY, Nickels ML, Dawson ES, Zhao P, Saleh S, Buck JR, Tang D, Washington MK, Coffey RJ, Manning HC.

Clin Cancer Res. 2014 Apr 15;20(8):2126-35. doi: 10.1158/1078-0432.CCR-13-2444. Epub 2014 Feb 26.


Preclinical Kinetic Analysis of the Caspase-3/7 PET Tracer 18F-C-SNAT: Quantifying the Changes in Blood Flow and Tumor Retention After Chemotherapy.

Palner M, Shen B, Jeon J, Lin J, Chin FT, Rao J.

J Nucl Med. 2015 Sep;56(9):1415-21. doi: 10.2967/jnumed.115.155259. Epub 2015 Jun 4.


Imaging caspase-3 activation as a marker of apoptosis-targeted treatment response in cancer.

Chen DL, Engle JT, Griffin EA, Miller JP, Chu W, Zhou D, Mach RH.

Mol Imaging Biol. 2015 Jun;17(3):384-93. doi: 10.1007/s11307-014-0802-8.


Temporal and spatial evolution of therapy-induced tumor apoptosis detected by caspase-3-selective molecular imaging.

Nguyen QD, Lavdas I, Gubbins J, Smith G, Fortt R, Carroll LS, Graham MA, Aboagye EO.

Clin Cancer Res. 2013 Jul 15;19(14):3914-24. doi: 10.1158/1078-0432.CCR-12-3814. Epub 2013 May 31.


Functional imaging of oxidative stress with a novel PET imaging agent, 18F-5-fluoro-L-aminosuberic acid.

Webster JM, Morton CA, Johnson BF, Yang H, Rishel MJ, Lee BD, Miao Q, Pabba C, Yapp DT, Schaffer P.

J Nucl Med. 2014 Apr;55(4):657-64. doi: 10.2967/jnumed.113.126664. Epub 2014 Feb 27.


Positron emission tomography imaging of drug-induced tumor apoptosis with a caspase-3/7 specific [18F]-labeled isatin sulfonamide.

Nguyen QD, Smith G, Glaser M, Perumal M, Arstad E, Aboagye EO.

Proc Natl Acad Sci U S A. 2009 Sep 22;106(38):16375-80. doi: 10.1073/pnas.0901310106. Epub 2009 Sep 3.


In Vivo Evaluation of Radiofluorinated Caspase-3/7 Inhibitors as Radiotracers for Apoptosis Imaging and Comparison with [18F]ML-10 in a Stroke Model in the Rat.

Médoc M, Dhilly M, Matesic L, Toutain J, Krause-Heuer AM, Delamare J, Fraser BH, Touzani O, Barré L, Greguric I, Sobrio F.

Mol Imaging Biol. 2016 Feb;18(1):117-26. doi: 10.1007/s11307-015-0865-1.


Immuno-PET imaging of tumor endothelial marker 8 (TEM8).

Kuo F, Histed S, Xu B, Bhadrasetty V, Szajek LP, Williams MR, Wong K, Wu H, Lane K, Coble V, Vasalatiy O, Griffiths GL, Paik CH, Elbuluk O, Szot C, Chaudhary A, St Croix B, Choyke P, Jagoda EM.

Mol Pharm. 2014 Nov 3;11(11):3996-4006. doi: 10.1021/mp500056d. Epub 2014 Jul 11.


Apoptosis imaging probe predicts early chemotherapy response in preclinical models: A comparative study with 18F-FDG PET.

Song S, Xiong C, Lu W, Ku G, Huang G, Li C.

J Nucl Med. 2013 Jan;54(1):104-10. doi: 10.2967/jnumed.112.109397.


Synthesis and in vitro and in vivo evaluation of an (18)F-labeled neuropeptide Y analogue for imaging of breast cancer by PET.

Hofmann S, Maschauer S, Kuwert T, Beck-Sickinger AG, Prante O.

Mol Pharm. 2015 Apr 6;12(4):1121-30. doi: 10.1021/mp500601z. Epub 2015 Mar 13.


Evaluation of chemotherapy response in VX2 rabbit lung cancer with 18F-labeled C2A domain of synaptotagmin I.

Wang F, Fang W, Zhang MR, Zhao M, Liu B, Wang Z, Hua Z, Yang M, Kumata K, Hatori A, Yamasaki T, Yanamoto K, Suzuki K.

J Nucl Med. 2011 Apr;52(4):592-9. doi: 10.2967/jnumed.110.081588. Epub 2011 Mar 18.


5-(2-18F-fluoroethoxy)-L-tryptophan as a substrate of system L transport for tumor imaging by PET.

Krämer SD, Mu L, Müller A, Keller C, Kuznetsova OF, Schweinsberg C, Franck D, Müller C, Ross TL, Schibli R, Ametamey SM.

J Nucl Med. 2012 Mar;53(3):434-42. doi: 10.2967/jnumed.111.096289. Epub 2012 Feb 13.


99mTc-Duramycin SPECT Imaging of Early Tumor Response to Targeted Therapy: A Comparison with 18F-FDG PET.

Elvas F, Boddaert J, Vangestel C, Pak K, Gray B, Kumar-Singh S, Staelens S, Stroobants S, Wyffels L.

J Nucl Med. 2017 Apr;58(4):665-670. doi: 10.2967/jnumed.116.182014. Epub 2016 Nov 22.


Comparison of (18)F-labeled CXCR4 antagonist peptides for PET imaging of CXCR4 expression.

Zhang XX, Sun Z, Guo J, Wang Z, Wu C, Niu G, Ma Y, Kiesewetter DO, Chen X.

Mol Imaging Biol. 2013 Dec;15(6):758-67. doi: 10.1007/s11307-013-0640-0. Erratum in: Mol Imaging Biol. 2013 Dec;15(6):788.


Utilizing the Multiradionuclide Resolving Power of SPECT and Dual Radiolabeled Single Molecules to Assess Treatment Response of Tumors.

Xu B, Shokeen M, Sudlow GP, Harpstrite SE, Liang K, Cheney PP, Edwards WB, Sharma V, Laforest R, Akers WJ, Achilefu S.

Mol Imaging Biol. 2015 Oct;17(5):671-9. doi: 10.1007/s11307-015-0842-8.


Preclinical assessment of carboplatin treatment efficacy in lung cancer by 18F-ICMT-11-positron emission tomography.

Witney TH, Fortt R, Aboagye EO.

PLoS One. 2014 Mar 11;9(3):e91694. doi: 10.1371/journal.pone.0091694. eCollection 2014. Erratum in: PLoS One. 2014;9(6):e100020. Fortt, Robin R [corrected to Fortt, R].

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