Sort by
Items per page

Send to

Choose Destination

Links from PubMed

Items: 1 to 20 of 154


Two distinct modes of ATR activation orchestrated by Rad17 and Nbs1.

Shiotani B, Nguyen HD, Håkansson P, Maréchal A, Tse A, Tahara H, Zou L.

Cell Rep. 2013 May 30;3(5):1651-62. doi: 10.1016/j.celrep.2013.04.018. Epub 2013 May 16.


Single-stranded DNA orchestrates an ATM-to-ATR switch at DNA breaks.

Shiotani B, Zou L.

Mol Cell. 2009 Mar 13;33(5):547-58. doi: 10.1016/j.molcel.2009.01.024.


Distinct roles for DNA-PK, ATM and ATR in RPA phosphorylation and checkpoint activation in response to replication stress.

Liu S, Opiyo SO, Manthey K, Glanzer JG, Ashley AK, Amerin C, Troksa K, Shrivastav M, Nickoloff JA, Oakley GG.

Nucleic Acids Res. 2012 Nov;40(21):10780-94. doi: 10.1093/nar/gks849. Epub 2012 Sep 12.


DNA-PK phosphorylation of RPA32 Ser4/Ser8 regulates replication stress checkpoint activation, fork restart, homologous recombination and mitotic catastrophe.

Ashley AK, Shrivastav M, Nie J, Amerin C, Troksa K, Glanzer JG, Liu S, Opiyo SO, Dimitrova DD, Le P, Sishc B, Bailey SM, Oakley GG, Nickoloff JA.

DNA Repair (Amst). 2014 Sep;21:131-9. doi: 10.1016/j.dnarep.2014.04.008. Epub 2014 May 10.


Reconstitution of RPA-covered single-stranded DNA-activated ATR-Chk1 signaling.

Choi JH, Lindsey-Boltz LA, Kemp M, Mason AC, Wold MS, Sancar A.

Proc Natl Acad Sci U S A. 2010 Aug 3;107(31):13660-5. doi: 10.1073/pnas.1007856107. Epub 2010 Jun 28.


NBS1 directly activates ATR independently of MRE11 and TOPBP1.

Kobayashi M, Hayashi N, Takata M, Yamamoto K.

Genes Cells. 2013 Mar;18(3):238-46. doi: 10.1111/gtc.12031. Epub 2013 Feb 1.


RHINO forms a stoichiometric complex with the 9-1-1 checkpoint clamp and mediates ATR-Chk1 signaling.

Lindsey-Boltz LA, Kemp MG, Capp C, Sancar A.

Cell Cycle. 2015;14(1):99-108. doi: 10.4161/15384101.2014.967076.


Cep164 is a mediator protein required for the maintenance of genomic stability through modulation of MDC1, RPA, and CHK1.

Sivasubramaniam S, Sun X, Pan YR, Wang S, Lee EY.

Genes Dev. 2008 Mar 1;22(5):587-600. doi: 10.1101/gad.1627708. Epub 2008 Feb 18.


Phosphorylation of replication protein A by S-phase checkpoint kinases.

Liu JS, Kuo SR, Melendy T.

DNA Repair (Amst). 2006 Mar 7;5(3):369-80. Epub 2006 Jan 18.


Rad9, Rad17, TopBP1 and claspin play essential roles in heat-induced activation of ATR kinase and heat tolerance.

Tuul M, Kitao H, Iimori M, Matsuoka K, Kiyonari S, Saeki H, Oki E, Morita M, Maehara Y.

PLoS One. 2013;8(2):e55361. doi: 10.1371/journal.pone.0055361. Epub 2013 Feb 1.


Sensing DNA damage through ATRIP recognition of RPA-ssDNA complexes.

Zou L, Elledge SJ.

Science. 2003 Jun 6;300(5625):1542-8.


Function of the ATR N-terminal domain revealed by an ATM/ATR chimera.

Chen X, Zhao R, Glick GG, Cortez D.

Exp Cell Res. 2007 May 1;313(8):1667-74. Epub 2007 Feb 27.


Interaction between Rad9-Hus1-Rad1 and TopBP1 activates ATR-ATRIP and promotes TopBP1 recruitment to sites of UV-damage.

Ohashi E, Takeishi Y, Ueda S, Tsurimoto T.

DNA Repair (Amst). 2014 Sep;21:1-11. doi: 10.1016/j.dnarep.2014.05.001. Epub 2014 May 27.


Distinct roles of ATR and DNA-PKcs in triggering DNA damage responses in ATM-deficient cells.

Tomimatsu N, Mukherjee B, Burma S.

EMBO Rep. 2009 Jun;10(6):629-35. doi: 10.1038/embor.2009.60. Epub 2009 May 15.


A role for the MRN complex in ATR activation via TOPBP1 recruitment.

Duursma AM, Driscoll R, Elias JE, Cimprich KA.

Mol Cell. 2013 Apr 11;50(1):116-22. doi: 10.1016/j.molcel.2013.03.006.


Requirement for NBS1 in the S phase checkpoint response to DNA methylation combined with PARP inhibition.

Horton JK, Stefanick DF, Zeng JY, Carrozza MJ, Wilson SH.

DNA Repair (Amst). 2011 Feb 7;10(2):225-34. doi: 10.1016/j.dnarep.2010.11.003. Epub 2010 Dec 3.


Suppression of Tousled-like kinase activity after DNA damage or replication block requires ATM, NBS1 and Chk1.

Krause DR, Jonnalagadda JC, Gatei MH, Sillje HH, Zhou BB, Nigg EA, Khanna K.

Oncogene. 2003 Sep 4;22(38):5927-37.


NBS1 mediates ATR-dependent RPA hyperphosphorylation following replication-fork stall and collapse.

Manthey KC, Opiyo S, Glanzer JG, Dimitrova D, Elliott J, Oakley GG.

J Cell Sci. 2007 Dec 1;120(Pt 23):4221-9. Epub 2007 Nov 14.


Chk1- and claspin-dependent but ATR/ATM- and Rad17-independent DNA replication checkpoint response in HeLa cells.

Rodríguez-Bravo V, Guaita-Esteruelas S, Florensa R, Bachs O, Agell N.

Cancer Res. 2006 Sep 1;66(17):8672-9.

Supplemental Content

Support Center