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Items: 1 to 20 of 104

1.

Identification of cinnamic acid derivatives as novel antagonists of the prokaryotic proton-gated ion channel GLIC.

Prevost MS, Delarue-Cochin S, Marteaux J, Colas C, Van Renterghem C, Blondel A, Malliavin T, Corringer PJ, Joseph D.

J Med Chem. 2013 Jun 13;56(11):4619-30. doi: 10.1021/jm400374q. Epub 2013 Jun 4.

PMID:
23682762
2.

Site-directed spin labeling reveals pentameric ligand-gated ion channel gating motions.

Dellisanti CD, Ghosh B, Hanson SM, Raspanti JM, Grant VA, Diarra GM, Schuh AM, Satyshur K, Klug CS, Czajkowski C.

PLoS Biol. 2013 Nov;11(11):e1001714. doi: 10.1371/journal.pbio.1001714. Epub 2013 Nov 19.

3.
4.

Functional prokaryotic-eukaryotic chimera from the pentameric ligand-gated ion channel family.

Duret G, Van Renterghem C, Weng Y, Prevost M, Moraga-Cid G, Huon C, Sonner JM, Corringer PJ.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12143-8. doi: 10.1073/pnas.1104494108. Epub 2011 Jul 5.

5.

Multisite binding of a general anesthetic to the prokaryotic pentameric Erwinia chrysanthemi ligand-gated ion channel (ELIC).

Spurny R, Billen B, Howard RJ, Brams M, Debaveye S, Price KL, Weston DA, Strelkov SV, Tytgat J, Bertrand S, Bertrand D, Lummis SC, Ulens C.

J Biol Chem. 2013 Mar 22;288(12):8355-64. doi: 10.1074/jbc.M112.424507. Epub 2013 Jan 30.

6.

A prokaryotic proton-gated ion channel from the nicotinic acetylcholine receptor family.

Bocquet N, Prado de Carvalho L, Cartaud J, Neyton J, Le Poupon C, Taly A, Grutter T, Changeux JP, Corringer PJ.

Nature. 2007 Jan 4;445(7123):116-9. Epub 2006 Dec 10.

PMID:
17167423
7.

Structure of the pentameric ligand-gated ion channel GLIC bound with anesthetic ketamine.

Pan J, Chen Q, Willenbring D, Mowrey D, Kong XP, Cohen A, Divito CB, Xu Y, Tang P.

Structure. 2012 Sep 5;20(9):1463-9. doi: 10.1016/j.str.2012.08.009.

8.

Signal transduction pathways in the pentameric ligand-gated ion channels.

Mowrey D, Chen Q, Liang Y, Liang J, Xu Y, Tang P.

PLoS One. 2013 May 8;8(5):e64326. doi: 10.1371/journal.pone.0064326. Print 2013.

9.

Anesthetic binding in a pentameric ligand-gated ion channel: GLIC.

Chen Q, Cheng MH, Xu Y, Tang P.

Biophys J. 2010 Sep 22;99(6):1801-9. doi: 10.1016/j.bpj.2010.07.023.

10.

Neurotoxic phospholipase A2 from rattlesnake as a new ligand and new regulator of prokaryotic receptor GLIC (proton-gated ion channel from G. violaceus).

Ostrowski M, Porowinska D, Prochnicki T, Prevost M, Raynal B, Baron B, Sauguet L, Corringer PJ, Faure G.

Toxicon. 2016 Jun 15;116:63-71. doi: 10.1016/j.toxicon.2016.02.002. Epub 2016 Feb 5.

PMID:
26854368
11.

Photoaffinity labeling the propofol binding site in GLIC.

Chiara DC, Gill JF, Chen Q, Tillman T, Dailey WP, Eckenhoff RG, Xu Y, Tang P, Cohen JB.

Biochemistry. 2014 Jan 14;53(1):135-42. doi: 10.1021/bi401492k. Epub 2013 Dec 30.

12.

Inhibition versus potentiation of ligand-gated ion channels can be altered by a single mutation that moves ligands between intra- and intersubunit sites.

Brömstrup T, Howard RJ, Trudell JR, Harris RA, Lindahl E.

Structure. 2013 Aug 6;21(8):1307-16. doi: 10.1016/j.str.2013.06.018. Epub 2013 Jul 25.

13.

Structural basis for alcohol modulation of a pentameric ligand-gated ion channel.

Howard RJ, Murail S, Ondricek KE, Corringer PJ, Lindahl E, Trudell JR, Harris RA.

Proc Natl Acad Sci U S A. 2011 Jul 19;108(29):12149-54. doi: 10.1073/pnas.1104480108. Epub 2011 Jul 5.

14.

Macroscopic kinetics of pentameric ligand gated ion channels: comparisons between two prokaryotic channels and one eukaryotic channel.

Laha KT, Ghosh B, Czajkowski C.

PLoS One. 2013 Nov 19;8(11):e80322. doi: 10.1371/journal.pone.0080322. eCollection 2013.

15.

Structure of a potentially open state of a proton-activated pentameric ligand-gated ion channel.

Hilf RJ, Dutzler R.

Nature. 2009 Jan 1;457(7225):115-8. doi: 10.1038/nature07461. Epub 2008 Nov 5.

PMID:
18987630
16.

Inhibition of the prokaryotic pentameric ligand-gated ion channel ELIC by divalent cations.

Zimmermann I, Marabelli A, Bertozzi C, Sivilotti LG, Dutzler R.

PLoS Biol. 2012;10(11):e1001429. doi: 10.1371/journal.pbio.1001429. Epub 2012 Nov 20.

17.

Perturbation of Critical Prolines in Gloeobacter violaceus Ligand-gated Ion Channel (GLIC) Supports Conserved Gating Motions among Cys-loop Receptors.

Rienzo M, Rocchi AR, Threatt SD, Dougherty DA, Lummis SC.

J Biol Chem. 2016 Mar 18;291(12):6272-80. doi: 10.1074/jbc.M115.694372. Epub 2015 Dec 14.

18.

Study, by use of coarse-grained models, of the functionally crucial residues and allosteric pathway of anesthetic regulation of the Gloeobacter violaceus ligand-gated ion channel.

Li XY, Xie F, Zhang JC, Su JG.

Eur Biophys J. 2014 Dec;43(12):623-30. doi: 10.1007/s00249-014-0992-7. Epub 2014 Nov 4.

PMID:
25367560
19.

Crystal structures of a pentameric ligand-gated ion channel provide a mechanism for activation.

Sauguet L, Shahsavar A, Poitevin F, Huon C, Menny A, Nemecz À, Haouz A, Changeux JP, Corringer PJ, Delarue M.

Proc Natl Acad Sci U S A. 2014 Jan 21;111(3):966-71. doi: 10.1073/pnas.1314997111. Epub 2013 Dec 23.

20.

Ion selectivity mechanism in a bacterial pentameric ligand-gated ion channel.

Fritsch S, Ivanov I, Wang H, Cheng X.

Biophys J. 2011 Jan 19;100(2):390-8. doi: 10.1016/j.bpj.2010.11.077.

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