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SIRT1 activation enhances HDAC inhibition-mediated upregulation of GADD45G by repressing the binding of NF-κB/STAT3 complex to its promoter in malignant lymphoid cells.

Scuto A, Kirschbaum M, Buettner R, Kujawski M, Cermak JM, Atadja P, Jove R.

Cell Death Dis. 2013 May 16;4:e635. doi: 10.1038/cddis.2013.159.


Resveratrol sensitizes acute myelogenous leukemia cells to histone deacetylase inhibitors through reactive oxygen species-mediated activation of the extrinsic apoptotic pathway.

Yaseen A, Chen S, Hock S, Rosato R, Dent P, Dai Y, Grant S.

Mol Pharmacol. 2012 Dec;82(6):1030-41. doi: 10.1124/mol.112.079624. Epub 2012 Aug 24.


B1, a novel HDAC inhibitor, induces apoptosis through the regulation of STAT3 and NF-κB.

Cheng MH, Wong YH, Chang CM, Yang CC, Chen SH, Yuan CL, Kuo HM, Yang CY, Chiu HF.

Int J Mol Med. 2017 May;39(5):1137-1148. doi: 10.3892/ijmm.2017.2946. Epub 2017 Apr 7.


PCI-24781 induces caspase and reactive oxygen species-dependent apoptosis through NF-kappaB mechanisms and is synergistic with bortezomib in lymphoma cells.

Bhalla S, Balasubramanian S, David K, Sirisawad M, Buggy J, Mauro L, Prachand S, Miller R, Gordon LI, Evens AM.

Clin Cancer Res. 2009 May 15;15(10):3354-65. doi: 10.1158/1078-0432.CCR-08-2365. Epub 2009 May 5. Erratum in: Clin Cancer Res. 2009 Jul 15;15(14):4784-5.


SRT1720, SRT2183, SRT1460, and resveratrol are not direct activators of SIRT1.

Pacholec M, Bleasdale JE, Chrunyk B, Cunningham D, Flynn D, Garofalo RS, Griffith D, Griffor M, Loulakis P, Pabst B, Qiu X, Stockman B, Thanabal V, Varghese A, Ward J, Withka J, Ahn K.

J Biol Chem. 2010 Mar 12;285(11):8340-51. doi: 10.1074/jbc.M109.088682. Epub 2010 Jan 8.


Zac1 is a histone acetylation-regulated NF-κB suppressor that mediates histone deacetylase inhibitor-induced apoptosis.

Shu G, Tang Y, Zhou Y, Wang C, Song JG.

Cell Death Differ. 2011 Dec;18(12):1825-35. doi: 10.1038/cdd.2011.51. Epub 2011 May 6.


Regulation of STAT3 by histone deacetylase-3 in diffuse large B-cell lymphoma: implications for therapy.

Gupta M, Han JJ, Stenson M, Wellik L, Witzig TE.

Leukemia. 2012 Jun;26(6):1356-64. doi: 10.1038/leu.2011.340. Epub 2011 Nov 25.


Sirtuin-1 (SIRT1) is required for promoting chondrogenic differentiation of mesenchymal stem cells.

Buhrmann C, Busch F, Shayan P, Shakibaei M.

J Biol Chem. 2014 Aug 8;289(32):22048-62. doi: 10.1074/jbc.M114.568790. Epub 2014 Jun 24.


Histone deacetylase inhibitor trichostatin A sustains sodium pervanadate-induced NF-kappaB activation by delaying IkappaBalpha mRNA resynthesis: comparison with tumor necrosis factor alpha.

Horion J, Gloire G, El Mjiyad N, Quivy V, Vermeulen L, Vanden Berghe W, Haegeman G, Van Lint C, Piette J, Habraken Y.

J Biol Chem. 2007 May 25;282(21):15383-93. Epub 2007 Apr 4.


NF-kappaB/STAT3/PI3K signaling crosstalk in iMyc E mu B lymphoma.

Han SS, Yun H, Son DJ, Tompkins VS, Peng L, Chung ST, Kim JS, Park ES, Janz S.

Mol Cancer. 2010 Apr 30;9:97. doi: 10.1186/1476-4598-9-97.


SIRT1 is upregulated in cutaneous T-cell lymphoma, and its inhibition induces growth arrest and apoptosis.

Nihal M, Ahmad N, Wood GS.

Cell Cycle. 2014;13(4):632-40. doi: 10.4161/cc.27523. Epub 2013 Dec 16. Erratum in: Cell Cycle. 2015;14(8):1337.


Sirt-1 is required for the inhibition of apoptosis and inflammatory responses in human tenocytes.

Busch F, Mobasheri A, Shayan P, Stahlmann R, Shakibaei M.

J Biol Chem. 2012 Jul 27;287(31):25770-81. doi: 10.1074/jbc.M112.355420. Epub 2012 Jun 11.


Benzyl isothiocyanate-mediated inhibition of histone deacetylase leads to NF-kappaB turnoff in human pancreatic carcinoma cells.

Batra S, Sahu RP, Kandala PK, Srivastava SK.

Mol Cancer Ther. 2010 Jun;9(6):1596-608. doi: 10.1158/1535-7163.MCT-09-1146. Epub 2010 May 18.


Sirt1 overexpression protects murine osteoblasts against TNF-α-induced injury in vitro by suppressing the NF-κB signaling pathway.

Huang W, Shang WL, Wang HD, Wu WW, Hou SX.

Acta Pharmacol Sin. 2012 May;33(5):668-74. doi: 10.1038/aps.2011.189. Epub 2012 Mar 26.


Histone Deacetylase Inhibitor RGFP109 Overcomes Temozolomide Resistance by Blocking NF-κB-Dependent Transcription in Glioblastoma Cell Lines.

Li ZY, Li QZ, Chen L, Chen BD, Wang B, Zhang XJ, Li WP.

Neurochem Res. 2016 Dec;41(12):3192-3205. Epub 2016 Sep 8.


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